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Biomedical subjects

T L Dunn

Publications and source records attributed to T L Dunn.

30 records · Page 2Linked to original sources
PubMed1985

Solid-phase radioimmunoassay for human neutrophil elastase: a sensitive method for determining secreted and cell-associated enzyme.

A solid-phase radioimmunoassay for measuring neutrophil elastase in the range 0.08-4 ng/ml has been developed. A monospecific, precipitating antibody capable of inhibiting elastinolysis was produced by repeated immunizations of a goat. The IgG fraction and affinity-purified antibodies of this serum were then obtained and used to develop this radioimmunoassay. There was no cross-reactivity in binding of the radiolabeled antisera with lactoferrin, cathepsin G, or serine proteinases with amino-terminal amino acid sequence homology. Although serum influences the measurement of catalytically active neutrophil elastase when compared to diisopropylfluorophosphate-treated neutrophil elastase, antigenic elastase may still be measured in body fluids. Furthermore, this assay is more sensitive than commercially available substrates used for quantitating neutrophil elastase by functional activity. We have found this quantitative assay extremely useful in balance studies to measure secreted and cell-associated elastase and in screening of biological fluids for the presence of the enzyme.

Animals↗
PubMed1983

Gastrointestinal involvement in lymphomatoid granulomatosis. Report of a case review of the literature.

Lymphomatoid granulomatosis is a lymphoproliferative process affecting multiple organ systems usually including the lungs. Significant gastrointestinal involvement, however, has rarely been reported. Pathologic examination reveals a vasocentric polymorphous lymphoid infiltrate. A case of lymphomatoid granulomatosis with gastrointestinal manifestations necessitating aggressive surgical intervention is reported. The clinical presentation, pathologic features, and various aspects of therapy of lymphomatoid granulomatosis involving the gastrointestinal tract are discussed.

Adult↗
PubMed1981

Hypersensitivity pneumonitis and mesangiopathic glomerulonephritis: an unusual pulmonary-renal syndrome.

A broad range of disorders can manifest themselves as pulmonary-renal syndromes; the etiology and pathophysiology of most of these remain unknown. Although the occurrence of classic hypersensitivity pneumonitis with glomerulonephritis is rare, there is the possibility of at least some commonality of pathologic mechanisms. We present a case of mesangiopathic glomerulonephritis with renal failure complicated by a hypersensitivity-type pneumonitis, both of which were responsive to corticosteroids. The differential diagnostic considerations and alternate explanations for this syndrome are presented, as is the possibility that the renal and pulmonary abnormalities in this case represent a single disorder.

Alveolitis, Extrinsic Allergic↗
PubMed1980

EEG spectral analysis in schizophrenia.

Four channels of EEG (T4-T6, P4-02, T3-T5, P3-01) were recorded from several groups of control subjects and schizophrenia patients on analogue tape. They were later digitized and analysed by computer; power spectra were computed for 30 second epochs of EEG per channel; eyes closed, eyes open. No difference between normal controls and neurotic in-patients was apparent. An acute schizophrenic group had less alpha power, this change being confined largely to the temporal areas. A chronic outpatient sample showed less alpha and beta power, while chronic long-stay schizophrenic patients had an excess of delta power. The changes in both chronic patient groups were diffuse rather than local.

Acute Disease↗
PubMed1980

Tryptophan, cortisol and puerperal mood.

Plasma cortisol, free and total tryptophan were determined in 71 subjects on 8 occasions between 36 weeks gestation and 6 weeks post-partum. Affect was measured by rating scales and clinical interview. Twenty-eight subjects were judged to have experienced post-partum 'blues'. Seasonal variation occurred in the incidence of 'blues' and in cortisol and free tryptophan levels. Puerperally-depressed mood was correlated with high cortisol at 38 weeks irrespective of season. Free tryptophan was reduced in 'blues' subjects but only at the time of year when free tryptophan was normally high. Total tryptophan was low antenatally; a rapid rise on days 1 and 2 post-partum was superimposed on a slower return to normal. This initial peak was clearly absent in 37 per cent of subjects. Its absence was significantly related to occurrence of post-partum 'blues' and of complaints of depression in the ensuing 6 months. This finding is discussed in relation to the possible occurrence of an occult disturbance of tryptophan handling in subjects susceptible to depression.

11-Hydroxycorticosteroids↗
PubMed1977

Mood changes in puerperium, and plasma tryptophan and cortisol concentrations.

Eighteen women aged 18-31 years were studied daily during the second to fifth postpartum days to assess mood changes and plasma tryptophan and cortisol concentrations. Psychiatric rating scales, clinical interviews, and published biochemical methods were used. Over the period plasma free tryptophan concentrations tended to rise and plasma cortisol concentrations to decline. There was a positive correlation between plasma free tryptophan concentrations and mood state.

Adolescent↗
PubMed1976

Married women doctors' training and re-employment schemes in the West Midlands Region, with particular reference to psychiatry.

The response of one region to the Department of Health and Social Security recommendations on re-employment of women doctors contained in H.M. 69(6) is described. In many specialities there has been an encouraging return of married women doctors to medical practice within the hospital service. In the field of psychiatry the experience in a local sub-regional training scheme suggests that graduates of a high calibre can be attracted back to this speciality on a part-time basis for training; the training has been acceptable for full qualification and the examination success rate is high; part-time appointments, including senior registrar and consultant posts, can be obtained; it would not appear that training need, in the first instance, be confined to those people working in a main teaching centre; the satisfactory resolution of any conflict between trainees' domestic and professional commitments is important, as is a flexible approach to the individual professional needs of the trainees. Such schemes appear to tap a valuable source of potential manpower which higherto has not been fully utilized.

Education, Medical, Graduate↗
PubMed1973

Creutzfeldt-Jakob disease treated with amantidine. A report of two cases.

The treatment of two cases of Creutzfeldt-Jakob disease with amantidine is described. The first case made a remarkable initial improvement which was sustained for two months, but then deteriorated and died. Histological examination of the brain showed changes consistent with early Creutzfeldt-Jakob disease. The second case which was clinically one of Creutzfeldt-Jakob disease has now been followed for 30 months since the start of treatment and appears to be cured. It is considered that amantidine has a definite effect in this disease and it is suggested that its mode of action, though unknown, is more likely to be metabolic than antiviral.

Aged↗
PubMedDate not supplied

How should a consultant spend his time?

The activities of a whole-time consultant psychiatrist with clinical, teaching, and administrative responsibilities were analysed over six weeks. With the exclusion of time spent on call at night and weekends he worked an average of 57.4 hours a week. Altogether 42.3% of his time was spent on clinical work, 25.5% on general administration, and 24.0% on tutorial activities. Although he discharged his duties as well as might reasonably be expected, his clinical work was thought to have suffered. Postgraduate activities and medical administrations are important in the ultimate care of patients, but the structure of the National Health Service does not enable a consultant to meet all these demands adequately.

Consultants↗