Biomedical subjects

T L Kass

Publications and source records attributed to T L Kass.

2 recordsLinked to original sources

PubMed1976

On inverted repeat sequences in chromosomal DNA.

It is suggested that chromosomal DNA should contain a class of palindromic reverse repeats, comparable in number to that of genes themselves, which are formed as follows:(1) a transcription-termination signal that follows the gene plus (on the complementary strand and located as near to the "anti-gene" as possible); (2) a second termination signal which actively prevents the accidental transcription of the anti-gene. Thus, the adjacent termination-anti-termination region of one strand would complement the anti-termination-termination region of the other.

Chromosome Inversion↗

PubMed1974

On the structure of gene control regions.

A model emphasizing the possible genetic role of tandem duplications of reverse repeats has been developed as an extension of Crick's (1971) general model for the chromosomes of higher organisms. Although developed initially (1) to explain why random differences in the control regions of individual gene loci might confer a selective advantage on heterozygous individuals as well as (2) to offer the species a means by which such differences might be effected without mutational harm, it seems that control regions built on a foundation of tandemly duplicated reverse repeats would exhibit many properties previously observed in studies on mutable loci in various organisms.

Alleles↗