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T L PERRY

Publications and source records attributed to T L PERRY.

At least 19 recordsLinked to original sources
PubMed1964

7-HYDROXYCHLORPROMAZINE: POTENTIAL TOXIC DRUG METABOLITE IN PSYCHIATRIC PATIENTS.

7-Hydroxychlorpromazine was isolated from liver and urine of psychiatric patients treated with high dosages of chlorpromazine for long periods. These patients developed a purple pigmentation limited to areas of skin exposed to sunlight, as well as opacities of the cornea and lens. Large amounts of melanin were found only in the pigmented skin. It seems likely that a toxic compound is produced by the action of ultraviolet light on a 7-hydroxylated chlorpromazine derivative deposited in skin, cornea, and lens, and that this in turn leads to excessive melanin production and eye changes.

Body Fluids↗
PubMed1962

Urinary excretion of amines in phenylketonuria and mongolism.

Children with phenylketonuria excrete considerably less serotonin and tryptamine and somewhat less normetanephrine and p-tyramine than normal children. The excretion of these amines was not decreased in mongolism. Even during monoamine oxidase blockade, o-tyramine could not be detected in the urine of phenylketonurics. These findings are discussed in relation to the mental defect of phenylketonuria.

Amines↗