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Biomedical subjects

T L Ward

Publications and source records attributed to T L Ward.

16 recordsLinked to original sources
PubMed1995

Effect of chromium tripicolinate on growth, glucose tolerance, insulin sensitivity, plasma metabolites, and growth hormone in pigs.

Two experiments were conducted to evaluate the effect of Cr as Cr tripicolinate (CrPic) on growth, glucose tolerance, insulin sensitivity, plasma metabolites, and growth hormone (GH) in pigs. Pigs were fed a control diet or a diet supplemented with 200 micrograms of Cr/kg of diet as CrPic. Thirty (15 per diet, initial BW was 21.3 kg) and 24 (12 per diet, initial BW was 24.9 kg) crossbred barrows were used in Exp. 1 and 2, respectively. The diets were formulated to provide 120% of the lysine requirement for 20- to 50-kg pigs. A glucose tolerance test (IVGTT; 500 mg of glucose/kg BW) and an insulin challenge test (IVICT; .1 IU of porcine insulin/kg BW) were conducted. In addition, during Exp. 1, a GH-releasing hormone (GHRH) challenge was conducted. All data were pooled across experiments, except where noted. Average daily gain, ADFI, gain/feed, and fasting (15 to 18 h) plasma glucose and total protein concentrations were not affected (P > .10) by dietary treatment. Fasting plasma cholesterol (P < .05) was increased and NEFA (Exp. 2 only, P < .02), urea N (P < .07), and insulin (P < .10) concentrations were decreased in pigs fed CrPic. During the IVGTT and IVICT, glucose disappearance rate (k, percentage/minute) was increased (P < .04) and glucose half-life (t1/2, minutes) was decreased (P < .04) in pigs fed CrPic; however, insulin kinetics were not altered (P > .10). During the GHRH challenge, pigs fed CrPic had decreased (P < .09) area under the response curve for GH.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1995

Sorghum amino acid-supplemented diets for the 50- to 100-kilogram pig.

Three experiments were conducted to evaluate lysine (Lys), threonine (Thr), methionine (Met), tryptophan (Trp), and nonessential N (+N) supplementation of all sorghum grain (S) diets on growth and carcass characteristics of 50- to 100-kg pigs. In Exp. 1, four replicate pens of four pigs each were fed: 1) sorghum-soybean meal positive control (S-SBM); 2) S + Lys + Thr + Met + Trp to equal the amino acid concentrations in S-SBM (LTMT); 3) Diet 2 + N (LTMT+N); and 4) S negative control. Compared with pigs fed S-SBM, pigs fed LTMT or LTMT+N had reduced (P < .05) ADG, ADFI, serum urea N (SUN), pancreas weight, LMA, and percentage of muscling (PM) but higher dressing percentage (DP) and similar 10th rib fat thickness (TRF). Apparent N digestibility was lower (P < .05) in pigs fed LTMT than in pigs fed LTMT+N or S-SBM. In Exp. 2, two replicate pens of four pigs each were fed: 1) S-SBM; 2) S + Lys + Thr (LT); 3) S + Lys + Thr + Met (LTM); 4) S + Lys + Thr + Trp (LTT); 5) LTMT; 6 to 9) as 2 to 5 +N; and 10) S negative control. Compared with pigs fed S-SBM, pigs fed S, LT, LT+N, and LTM+N had lower (P < .05) ADG. Daily gain of pigs fed LTM, LTT, LTMT, LTT+N, or LTMT+N was not different (P > .10) from pigs fed S-SBM.(ABSTRACT TRUNCATED AT 250 WORDS)

Amino Acids↗
PubMed1995

Effect of chromium picolinate on growth, body composition, and tissue accretion in pigs.

An experiment was conducted to evaluate the effect of dietary chromium picolinate (CrP) on growth and body composition of pigs. Twenty-four barrows (three from each of eight litters) were randomly allotted within litter to one of three treatments: 1) basal (B) diet from 19.1 to 106.4 kg BW (Control); 2) B from 19.1 to 57.2 kg BW and then B + 200 ppb of chromium as CrP from 57.2 to 106.4 kg BW (CrP-F); and 3) B + 200 ppb of chromium as CrP from 19.1 to 106.4 kg BW (CrP- GF). Average daily gain and ADFI were reduced (P < .08) and first rib fat thickness was increased (P < .08) in pigs fed CrP-GF compared with pigs fed the Control diet. Specific gravity of the carcass was not affected (P > .10) by treatment. Tenth rib fat was reduced (P < .01) in pigs fed CrP-F compared with pigs fed CrP-GF, and percentage of muscle was increased in pigs fed CrP-F (P < .09) compared with pigs fed either the Control or CrP-GF diets. Leaf fat (P < .05) and lung weights (P < .08) were reduced in pigs fed CrP-F compared with pigs fed CrP-GF. As determined by physical-chemical separation, pigs fed CrP-GF had an increased (P < .07) percentage of intermuscular fat compared with pigs fed the Control or CrP-F diets. Pigs fed CrP-F had a lesser (P < .07) percentage of total fat and a greater (P < .07) percentage of muscle than pigs fed the Control or CrP-GF diets. As determined by mechanical-chemical separation, pigs fed CrP-F had a greater (P < .10) percentage of moisture than pigs fed the Control diet and a lesser (P < .10) percentage of fat and a greater (P < .06) percentage of ash than pigs fed the Control or CrP-GF diets. Pigs fed CrP-GF had an increased (P < .04) daily fat accretion compared with pigs fed CrP-F. Sensory and shear force values were not affected by CrP, with the exception that meat from pigs fed CrP-GF had a greater (P < .10) shear force value than meat from pigs fed CrP-F. These results suggest that dietary supplementation of CrP in the finishing phase of pig production may increase muscle and decrease fat deposition; however, not all measures of muscling or fatness were improved by CrP.

Animals↗
PubMed1995

Interactive effects of dietary copper, water copper, and Eimeria spp. infection on growth, water intake, and plasma and liver copper concentrations of poults.

The effects of dietary Cu, water Cu, and coccidial infection on poult growth performance and selected tissue mineral concentrations were investigated in a 10-d experiment using 200 5-d-old Nicholas toms (five replicates of 5 poults each; initial weight = 85 g). Uninfected and coccidiosis-infected (Eimeria meleagrimitis, Eimeria dispersa, Eimeria adenoeides, and Eimeria gallopavonis; cocci) poults were assigned to two levels of dietary Cu [Basal (B) and B + 204 mg Cu/kg diet on Days 1 to 10] and two levels of water Cu (0 and 103 mg Cu/kg water on Days 6 to 10). Dietary Cu and water Cu (main effects) did not affect (P > .10) gain, feed intake, gain:feed, water intake, hemoglobin, hematocrit, or liver Fe and Zn concentrations. Dietary Cu and water Cu increased (P < .03) liver and plasma Cu concentrations. The combination of dietary Cu and water Cu increased plasma Cu more than the sum of the Cu additions (dietary Cu by water Cu, P < .08). Coccidial infection reduced (P < .07) gain, feed intake, gain:feed, water intake, and hemoglobin, and increased (P < .02) liver Zn. Water Cu reduced water intake in uninfected poults but increased water intake in coccidiosis-infected poults (water Cu by cocci, P < .07). Water Cu increased hemoglobin in uninfected poults but decreased hemoglobin in coccidiosis-infected poults (water Cu by cocci, P < .07). Water Cu increased plasma Cu and liver Cu more in coccidiosis-infected poults than in uninfected poults (water Cu by cocci, P < .02).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1994

Plasma concentrations of prolactin, glucose, insulin, urea nitrogen, and total amino acids in stallions after ingestion of feed or gastric administration of feed components.

Concentrations of prolactin, glucose, insulin, urea N, and total amino acids in plasma of stallions after ingestion of pelleted feed were compared to those after direct gastric administration of water, NaCl, egg albumin, or corn starch (Exp. 1) or water, egg albumin, hydrolyzed casein (Amicase), or a mixture of indispensable amino acids (Exp. 2). Stallions were fed once daily (75% pellet and 25% hay) at 1500 for 30 d. On d 22, 24, 26, 28, and 30, blood samples were collected every 30 min from 1 h before through 4 h after treatment, which occurred at 1100. In Exp. 1, there was a positive secretory response for prolactin (P = .013) only after the meal. Positive glucose and insulin responses were observed after the meal (P < .055) and after gastric administration of corn starch (P < .001). Total amino acids increased (P = .008) only after the meal. In Exp. 2, a positive prolactin response (P < .001) occurred after the meal and a negative response (P = .023) after administration of water; administration of Amicase increased (P = .061) prolactin concentrations after a 2.5-h delay. Positive responses were observed for glucose, insulin, and total amino acids after the meal (P < .001) and after administration of Amicase or the amino acid mixture (P < .026). Positive urea N responses were observed after administration of Amicase and the amino acid mixture (P < .001).(ABSTRACT TRUNCATED AT 250 WORDS)

Amino Acids↗
PubMed1994

Effect of sodium bentonite or hydrated sodium calcium aluminosilicate on growth performance and tibia mineral concentrations in broiler chicks fed nutrient-deficient diets.

An experiment was conducted to determine whether sodium bentonite (NaB) or hydrated sodium calcium aluminosilicate (HSCA) would affect growth performance and tibia mineral concentrations in chicks fed nutrient-deficient diets. Two identical trials were conducted; each using 240 5- to 19-d-old broiler chicks (4 replicates of 5 chicks each) in a completely random design. A factorial arrangement of treatments consisted of four types of nutrient deficiencies [nutritionally complete basal (C), macromineral-deficient (-MM), trace mineral- and vitamin-deficient (-TMV), and crude protein-deficient (-CP)], and three types of additive (none, .5% NaB, and .5% HSCA). The -MM and -TMV diets reduced (P < .01), gain, feed intake, and gain:feed. The -CP diet decreased (P < .01) gain and gain:feed but did not affect (P > .10) feed intake. Sodium bentonite increased feed intake (P < .01) of all diets; resulting in an increase in gain (P < .09). Sodium bentonite increased gain:feed in chicks fed the -MM diet but did not affect gain:feed in chicks fed the C, -TMV, or -CP diets (NaBx-MM interaction, P < .02). The -MM and -TMV diets decreased (P < .01) tibia ash, but the -CP diet increased (P < .01) tibia ash. The -MM diet decreased (P < .01) tibia Ca but increased (P < .01) tibia P. Neither NaB nor HSCA affected percentage of tibia ash, Ca, or P. Tibia Zn and Mn concentrations were increased (P < .01) by the -MM diet and decreased (P < .01) by the -TMV diet.(ABSTRACT TRUNCATED AT 250 WORDS)

Aluminum Silicates↗
PubMed1994

Interactive effects of dietary copper and water copper level on growth, water intake, and plasma and liver copper concentrations of poults.

The interactive effects of dietary Cu and water Cu on poult growth, water intake, whole-blood hemoglobin (Hb), and plasma and liver Cu concentrations were investigated using 232-9-old toms. Poults were randomly assigned to two levels of dietary Cu [Basal (B) and B + 204 mg Cu/kg diet] and to four levels of water Cu (0, 51.5, 103, and 206 mg Cu/kg water) in a 2 x 4 factorial arrangement of treatments. Each treatment was replicated six times. All poults received tap water during Days 1 to 5 followed by the water Cu treatments during Days 6 to 10. Water intake was measured daily and gain and feed intake were determined on Days 5 and 10. Day 1 to 5 gain was reduced (P < .02) in poults fed supplemental dietary Cu. Day 1 to 5 feed intake and gain:feed and Day 6 to 10 gain, feed intake, gain:feed, and water intake were not affected (P > .10) by dietary Cu.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1994

Mineral content of Louisiana white-tailed deer.

Water, lipid, and mineral composition were determined for metacarpals, phalanges, livers, and antlers from 219 free-ranging white-tailed deer (Odocoileus virginianus) collected on six properties in East Feliciana Parish, Louisiana (USA) to provide baseline data and to identify sources of composition variation. Metacarpal and phalangeal composition varied primarily with deer age; liver composition varied with deer sex.

Age Factors↗
PubMed1993

Research note: interactive effects of sodium zeolite A and Eimeria acervulina infection on growth and tissue minerals in chicks.

Two experiments were conducted to assess the interactive effects of dietary sodium zeolite A (SZA) and experimental Eimeria acervulina infection on growth and tissue mineral concentrations in chicks. The average initial weight of the chicks was 71.8 g, and the experimental periods were from 5 to 15 days posthatching. In both experiments, the corn-soybean meal basal diet was supplemented with 0 or .75% SZA and fed to uninfected chicks or to chicks infected with 4 x 10(5) sporulated E. acervulina oocysts on Days 0, 3, and 6 of the experiments. Both coccidial infection and SZA reduced (P < .05) gain and feed intake; however, feed efficiency was reduced (P < .01) only in the coccidiosis-infected chicks. Neither SZA nor the coccidial infection affected (P > .10) plasma Ca or P, tibia P, liver Ca, Zn, Fe, or Mn, or pancreas Cu. Sodium zeolite A increased (P < .05) plasma Zn but only in uninfected chicks (SZA by coccidiosis, P < .10). The coccidial infection decreased (P < .02) tibia ash percentage. Sodium zeolite A decreased tibia Ca in uninfected chicks but increased tibia Ca in coccidiosis-infected chicks (SZA by coccidiosis, P < .10). The coccidial infection increased (P < .05) tibia Mg, Cu, Fe, Pb, Mn, and Al concentrations. Dietary SZA also increased (P < .02) tibia Zn, Mn, and Al concentrations. The coccidial infection decreased (P < .02) tibia Zn concentration, and SZA decreased (P < .05) tibia Mg and Fe. Sodium zeolite A by coccidiosis interactions (P < .10) were evident in tibia Zn, Fe, Mn, and Al concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1991

Incidental detection of hyperthyroidism during a perfusion lung scan for suspected pulmonary emboli.

Striking thyroidal uptake of Tc-99m pertechnetate was observed during the course of a perfusion lung scan performed with Tc-99m MAA to rule out pulmonary embolism in a 49-year-old man. There was no evidence of gastric pertechnetate activity. Radiochemical purity analysis of the Tc-MAA by chromatography in normal saline revealed 98.8% tagging, with 1.2% free pertechnetate. We estimate that a maximum of 60 microCi (2.2 MBq) of pertechnetate was available for thyroid trapping. This amount, given to a euthyroid volunteer studied with conventional gamma camera lung perfusion settings, failed to visualize the thyroid. A follow-up radioiodine thyroid uptake of the patient was markedly elevated, as was his thyroid function tests (T3,T7,T7). When diffuse intense thyroid gland radioactivity is seen during scintigraphy with a technetium radiopharmaceutical (e.g., bone and lung scans), consideration should be given to the possibility of hyperthyroidism. If gastric activity is not concomitantly seen, hyperthyroidism secondary to diffuse hyperplasia of the gland is probably present.

Humans↗
PubMed1991

Interactive effects of sodium zeolite-A and copper in growing swine: growth, and bone and tissue mineral concentrations.

An experiment was conducted with 64 crossbred pigs to determine the effect of 0 or .50% dietary sodium zeolite-A (NZA) in combination with 0 or 250 ppm supplemental Cu (as CuSO4.5H2O). Pigs were assigned randomly to one of the following four treatments: 1) corn-soybean meal basal (B), 2) B + .50% NZA, 3) B + 250 ppm Cu, or 4) B + .50% NZA + 250 ppm Cu. Each treatment was replicated four times with four pigs per replicate. Average initial weight was 7.5 kg and the experimental period lasted 144 d. Overall rate and efficiency of gain, incidence of gastric ulcers, dressing percentage, carcass weight, percentage of muscling, 10th rib fat, loin eye area, blood urea N, and bone Ca, P, Mn, Fe, Ni, Na, and Al concentrations were not affected by treatment. The addition of 250 ppm Cu increased liver (P less than .01), serum (P less than .06), and bone (P less than .07) Cu concentrations but decreased mean backfat thickness (P less than .09), bone ash percentage (P less than .03) and serum (P less than .09) and bone (P less than .01) Zn concentrations. Sodium zeolite-A increased serum alkaline phosphatase (P less than .04), carcass length (P less than .06), and liver (P less than .02) and bone (P less than .01) Zn content but decreased (P less than .04) serum Ca and serum inorganic P concentrations. Sodium zeolite-A did not protect against liver Cu accumulation or gastric ulceration in growing swine fed 250 ppm supplemental Cu.

Adipose Tissue↗
PubMed1990

Interactive effects of sodium zeolite A (Ethacal) and monensin in uninfected and Eimeria acervulina-infected chicks.

An experiment was conducted with 5- to 18-day-old Arbor Acres broiler chicks to evaluate the interaction of sodium zeolite A (NZA) and monensin in uninfected and in coccidiosis-infected chicks. Sodium zeolite A (0 and .75%) or monensin (0 and 121 ppm), or both, were fed to uninfected chicks or to chicks infected with 4 x 10(5) sporulated, Eimeria acervulina oocysts, resulting in a 2-by-2-by-2 factorial arrangement of treatments. Coccidial infection reduced (P less than .01) weight gain, feed intake, feed efficiency, percentage of bone ash and of bone calcium; but the infection increased (P less than .05) bone Zn percentage. Monensin alleviated (or at least partially so) the adverse effects of the coccidial infection on weight gain, feed intake, feed efficiency and percentage of bone ash (coccidiosis by monensin, P less than .01). In addition, monensin increased the bone-calcium (P less than .06) and zinc content (P less than .02) in uninfected chicks and in those infected with coccidiosis. Sodium zeolite A tended to reduce feed intake by coccidiosis-infected chicks (coccidiosis by NZA, P less than .07), but increased (P less than .01) the bone zinc and decreased (P less than .01) serum inorganic phosphorus in uninfected chicks and in those infected with coccidiosis.

Aluminum Silicates↗
PubMed1983

The specific in vitro antibody-mediated retention of bovine serum albumin by porcine hyaline articular cartilage.

Porcine hyaline articular cartilage (HAC) has been used to investigate the interaction of bovine serum albumin (BSA) and anti-BSA with articular collagenous tissues in vitro. There was a marked retention of 125I-labelled BSA by plugs of HAC (a) exposed to rabbit anti-BSA for 1-2 h at 37 degrees C prior to a similar incubation with the antigen, or (b) exposed to the antigen and then to antibody. The specifically retained radiolabelled BSA was localized in or at the articular surface of the plugs. In the absence of specific antibody a relatively small amount of the antigen was retained. Exposure of HAC to multiple cycles of antibody and antigen treatment resulted in an increased retention of the 125I-BSA. There was a concomitant increase in the retention of the anti-BSA and the capacity of the treated plugs to fix complement. The forces that maintained the labelled antigen in the tissue were not readily reversed by excess unlabelled BSA. Pre-formed, soluble BSA/anti-BSA complexes did not appear to penetrate the tissue unless the HAC was first exposed to anti-BSA. The results suggest that the antibody-mediated, surface oriented retention of 125I-BSA results from the formation of immune complexes in the tissue.

Animals↗