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Biomedical subjects

T Landberg

Publications and source records attributed to T Landberg.

At least 55 records · Page 3Linked to original sources
PubMed1978

Clinico-pathological correlations in the Kiel classification of non-Hodgkin's lymphomata in children.

The rapid development of chemotherapy and radiotherapy during the last decade makes an increasing demand for a reliable classification of malignant non-Hodgkin's lymphomas. This is especially important in children since in this age group the lymphomas show a much worse prognosis than in adults. An attempt at a modern classification is offered by the so-called Kiel classification. 38 children with non-Hodgkin's lymphomas previously classified according to Rappaport were re-evaluated according to the Kiel system. Reclassification was technically feasible in 26 patients. There was good agreement on typing between the two independently working cytopathologists. 3 patients proved to be cases of histiocytic medullary reticulosis. Among the remaining patients, a much larger variety of histological subgroups was seen than in the one published paediatric series of Lennert. 17 patients had high-grade malignant lymphomas with lymphoblastic lymphomas predominating. Some clinical correlations not detectable with the Rappaport classification were found using the Kiel system. 6 patients were judged as having low-grade malignant lymphomas but in this group the survival was poorer than expected and 1 patient showed leukaemic transformation. The Kiel classification makes high demands for adequate surgical techniques and preparatory routines. It seems to represent a step forward in the classification of non-Hodgkin's lymphomas but much more experience is needed, especially in children, in order to evaluate its role as a guide to differentiated therapy.

Child↗
PubMed1978

Relaparotomy in advanced ovarian carcinoma.

Patients with Stage III ovarian carcinoma were treated either with extensive initial surgery and postoperative radiation therapy (17 patients) or with a less extensive initial laparotomy, postoperative radiation therapy and relaparotomy (19 patients). Better results were obtained among the patients in the latter group.

Adult↗
PubMed1978

En-bloc irradiation of tumours of the head and neck and their lymphatics. II. Early results and side effects.

The results and side effects of en-bloc irradiation of ear, nose and throat tumours and their lymphatics showed that the technique had been successful in nasopharyngeal carcinoma, but poor in carcinoma of the hypopharynx. Marked early and late radiation side effects were relatively common in high age and with certain tumour sites, whereas no correlation could be demonstrated with total absorbed dose, fractionation, cumulative radiation effect or major surgery.

Aged↗
PubMed1978

HLA antigens in Hodgkin's disease of very long survival.

Determination of 32 different HLA types in the A, B, and C series was performed in 40 patients with Hodgkin's disease, 10 of whom had a very long survival. A group of 1 263 healthy subjects was used as reference. HLA-B18 was seen significantly more often in all 40 patients and also in the subgroup of patients with nodular sclerosing Hodgkin's disease. An increased frequency of HLA-A28 was observed among the 10 long survivors, but only with weak significance.

Adolescent↗
PubMed1978

En-bloc irradiation of unresectable bronchogenic carcinomas and their regional lymphatics.

Patients with unresectable or inoperable bronchial carcinoma were treated with en-bloc irradiation of the tumour and the mediastinal lymph nodes to a total target absorbed dose of 40 Gy in 20 fractions. The first 52 patients were treated in one series and the last 45 patients in two series (split-course). Radiation adverse effects were only mild. The two regimens gave the same palliative results. The median survival was the same for the 2 groups (8 months). Most patients died in disseminated disease.

Adenocarcinoma↗
PubMed1977

Hodgkin's disease and acute leukaemia. A clinical and cytogenetic study.

Three patients developing acute myeloid leukaemia after treatment for Hodgkin's disease are reported. They appeared among 153 patients treated since 1971. All three patients were treated with high-voltage radiation of large target volumes as well as multiple-drug chemotherapy. In two of the patients chromosomal analyses of the leukaemic bone marrow cells were performed by modern banding technique. Chromosome abnormalities were found in both patients. The value of cytogenetic analysis with the new staining techniques for elucidating the mechanism of leukaemogenesis in Hodgkin's disease is discussed.

Adult↗
PubMed1977

Staging laparotomy with splenectomy in Hodgkin's disease.

The series includes 91 patients with Hodgkin's disease who underwent a staging laparotomy with splenectomy during the years 1971-1976, in 82% of them as part of the initial evaluation before therapy. Positive abdominal lymph nodes were found in 29% of the patients, a positive spleen in 37%, and a positive liver in 10%. Follow-up of patients who lacked abdominal involvement at laparotomy indicate that sampling error was only of marginal importance. Evaluation of the therapeutic implications of the operation indicated that 41% of the patients benefited from the procedure; 31% by changing stage and 10% by changing radiation therapy port. Five patients had minor surgical complications. The mortality rate was nil.

Abdominal Neoplasms↗
PubMed1976

Repeat scintigraphy of the internal mammary lymph nodes in rabbits.

Rabbits were subjected to different combinations of scintigraphy of the internal mammary lymph nodes, fractionated irradiation, and surgical trauma to the chest wall. No influence could be demonstrated on the image at repeat scintigraphy of the internal mammary nodes. Microscopic changes in the lymph nodes and vessels were relatively slight and inconstant.

Animals↗
PubMed1976

Mantle treatment of Hodgkin's disease. Results and side effects.

Eighty-seven patients were treated with the mantle technique for Hodgkin's disease. Usually 40 Gy in 27 fractions in two series over 71 days were given. A local recurrence was diagnosed in 3 of 87 patients. An analysis of radiation reactions of the lung tissue, heart and pericardium, and spinal cord is reported. It is recommended to give mantle treatment for Hodgkin's disease over a relatively long period of time such as in split-course in two series.

Adolescent↗
PubMed1976

Biopsy of the nasopharynx as a staging procedure in Hodgkin's disease.

Biopsy of the nasopharynx was perfomred in 45 patients with Hodgkin's disease as part of the pretherapeutic staging. Seven of the 45 (16%) had microscopic abnormalities in the nasopharynx compatible with Hodgkin's disease. Such abnormalities occurred even in the absence of local ENT-symptoms or signs, and they could not be predicted from the microscopic type of lymph node biopsy, stage of disease or general presentation. A generous biopsy of the nasopharynx is recommended to be included in the staging procedures in Hodgkin's disease.

Biopsy↗
PubMed1975

Manifest intestinal involvement during bone-marrow remission in a case of acute lymphoblastic leukaemia.

Massive leukaemic involvement of the intestine appeared in a 9-year-old girl with acute lymphoblastic leukaemia. The unusual feature in this case was that the gut involvement occurred during complete haematological remission. Surgical and subsequent radiological treatment completely eradicated the engagement and at autopsy 9 months later there were no signs of the intestinal involvement.

Autopsy↗
PubMed1975

Postirradiation syndrome and eeg findings in children with acute lymphoblastic leukaemia.

Out of 12 children with acute lymphoblastic leukaemia treated with craniospinal irradiation during primary haematologic remission, 8 developed a postirradiation syndrome characterized by fever and tiredness. The symptoms lasted 1-2 weeks and subsided spontaneously. Longitudinal EEG studies revealed no acute disturbances during the irradiation therapy but in all cases studied, moderate to severe diffuse general slowing developed during the postirradiation syndrome. Complete normalization of the EEG occurred in all children at follow-up. It is concluded that the described EEG abnormalities constitute an integral part of the postirradiation syndrome.

Adolescent↗