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Biomedical subjects

T Lange

Publications and source records attributed to T Lange.

At least 73 records · Page 4Linked to original sources
PubMed1989

Changes of the EMG and its relationship to the cardiopulmonary parameters during two-arm cranking of disabled men.

During two-arm cranking in 5 groups of men (able-bodied and leg-disabled with different states of training; wheelchair-dependents with basket-ball training) the behaviour of parameters of the motor and cardiopulmonary system (iEMG, heart rate, oxygen uptake) was investigated. On the basis of stepwise increasing physical work up to exhaustion the group of swimtrained leg-disabled men showed the highest physical working capacity. The lowest physical fitness was found in wheelchair-dependent men.

Adult↗
PubMed1988

[Acute changes in global and regional systolic heart function caused by pentoxifylline in patients with and without coronary sclerosis].

In 36 patients with angina pectoris during complex invasive diagnostic procedure the changes of global and regional systolic heart function by intravenous application of 200 mg pentoxifylline were examined. We observed a significant decrease of preload (reduction of LVEDP and MCS, LVEDV was not influenced) and an improvement of myocardial pump function, possibly combined with a favourable influence on alterated myocardial blood supply. In case of perfusion disturbances of the LV anterior wall the pentoxifylline injection was followed by signs of coronary-steal-mechanism in the LV posterior wall region. We did not found significant changes of afterload. Thus the acute hemodynamic effects of an intravenous application of pentoxifylline are comparable with those of nitrates and non-glycoside-cardiotonic substances with a predominant myocardial effect.

Coronary Artery Disease↗
PubMed1988

[Effects of pentoxifylline on diastolic heart function in patients with angina pectoris and an increased left ventricular wall mass].

The combination of coronary heart disease (CHD) with increased left ventricular wall mass (LVWM) appears associated with prolonged isovolumetric relaxation (IVR) and consequently, alterations in the rapid filling phase. Methylxanthine-substances may improve relaxation through inhibition of phosphodiesterase activity. Accordingly we examined multiple indexes of left ventricular diastolic function before and after administration of 200 mg pentoxifylline (Trental) intravenously to 18 patients (51.3 +/- 9.0 years, 15 males, three females) with stable angina pectoris and positive exercise-ECG in NYHA class I or II and LVWM greater than 160 g (n = 9) and less than or equal to 160 g (n = 9). Left ventricular pressure (P) and volume (V) measurements were made with a high-fidelity-micromanometer before and twelve minutes after administration of pentoxifylline. The time constant of left ventricular isovolumic relaxation (T), usual global left ventricular volumes and derived indexes such as peak filling rate (PFR), time to peak filling rate (TPFR), segmental (relaxation and rapid filling phases) and total pressure-volume relationship before and after pentoxifylline were calculated. Significant differences between these two groups (greater than/less than or equal to 160 g LVWM) were found for end-diastolic volume (68.7 +/- 19.0 to 90.8 +/- 22.6 ml/sqm), end-systolic volume (21.7 +/- 16.0 to 36.1 +/- 14.7 ml/sqm), end-diastolic pressure (15.0 +/- 4.8 to 15.7 +/- 5.1 mm Hg), PFR (3.25 +/- 1.18 to 2.66 +/- 0.71 s-1), T (46.0 +/- 5.7 to 52.7 +/- 7.2 ms), the linear regression of lnP-V (lny = -0.117 x + 4.59 to lny = -0.091 x + 4.75) in the IVR-phase (dp/dtmin less than or equal to x less than or equal to 80 ms) (leftward shift in p-V-relationship when less than or equal to 160 g) and the complet p-V-areas. After pentoxifyl-line-administration there were significant decreases in T in patients with increased LVWM (52.7 +/- 7.2 to 47.7 +/- 5.9 ms) and the P-V-product over the time in the rapid filling phase in patients with LVWM less than or equal to 160 g. Total peripheral resistance and heart rate did not change. These changes in parameters of left ventricular diastolic function in combination with significant improvement of pump function especially in patients with LVWM greater than 160 g after administration of pentoxifylline suggest that improved diastolic function is the result of a direct myocardial effect of pentoxifylline.

Adult↗
PubMed1986

Antibacterial efficacy of Fabry's tinctura on the resident flora of the skin at the forehead. Study of bacterial population dynamics in stratum corneum and infundibulum after single and repeated applications.

The in-vivo antibacterial activity of Fabry's tinctura (FT), a 3 w% salicylic acid, 1 w% phenoli liquefacti containing 50 v/v% isopropanol used in dermatology for the treatment of erythrasma, pityriasis versicolor, acne vulgaris a.o. on the human resident skin flora was assessed by a new test method in comparison to 60 v/v% isopropanol. The test method consists of a detergent scrub method (DSM) in combination with the cyanoacrylate method (CAM) thus allowing the quantitative determination of bacterial densities in two depth compartments of human skin, separately for bacterial genera. The most important innovation of this test method is that its arrangement, especially the separate evaluation of the genera of the resident flora, makes it possible to examine the ability of an antimicrobial agent to invade different depth compartments by its bioactivity against the resident flora and to measure short-and-long-term efficacies under physiological conditions. Our findings in 120 volunteers indicate that compared to 60% isopropanol FT is able to reduce bacterial density in superficial and deep skin compartments immediately after a single application equally well, but for a significantly longer period. In repeated applications, 60% isopropanol does not produce a cumulative or long-lasting effect, but it causes an abundant rebound growth of Propionibacterium spp. in the lower skin compartment. FT, however, shows a cumulative antibacterial effect at the surface and in the depth persisting up to four days after the last application. It is concluded that by its salicylic acid and phenolic content FT is an effective drug for the topical antimicrobial therapy of skin diseases.

1-Propanol↗
PubMed1981

Further studies on the hypothalamic desensitization to estrogen in immature female rats: evidence for a possible role in the control of puberty.

Immature and puberal female rats were ovariectomized and implanted with estradiol benzoate and cholesterol at the ratios of 1:120 or 1:240 into the hypothalamic ventromedial-arcuate region at 26 or 32 days of age, or on the day of the first vaginal estrus. Evaluation of the serum LH and FSH concentrations on the 2nd day after implantation revealed that the gonadotropin-inhibiting effect of the locally administered estrogen decreased between days 26 and 32 and showed a further distinct decline at the time of puberty. In a second experiment, uterine weight and serum LH and FSH levels were monitored in untreated immature female rats at daily intervals from 25 to 36 days of age. Relatively high values for both gonadotropins were recorded between days 25 and 28. Accelerated uterine growth around day 30 indicating increasing estrogen secretion was associated with a sudden decrease of LH and FSH concentration in the blood. After that, LH and, to a less degree FSH levels began to rise in spite of further weight gain of the uterus. The results suggest that the hypothalamic sensitivity to the gonadotropin-inhibiting effect of estrogen declines during the last week before the onset of puberty. Together with other findings they furthermore indicate that this desensitization process may be involved in the neurohormonal control of puberty in female rats.

Animals↗
PubMed1980

Evidence for direct central nervous inhibition of LH secretion during sexual maturation of female rats.

Intact and ovariectomized female rats were bilaterally lesioned in the anterior part of the medial amygdaloid nucleus (AMN) at 15, 21 or 26 days of age. The onset of puberty and the LH concentration in the peripheral serum on the third day after lesioning, respectively, were recorded. Damage to the AMN on day 15 induced a significant delay of vaginal opening and the first puberal ovulation and suppressed completely the castration-induced increase of LH secretion. In contrast, females lesioned on day 21 showed true precocious puberty and a significant elevation of the LH level as compared to the ovariectomized controls. The LH-inhibiting effect of s.c. administered estradiol benzoate (0.05 micrograms/100 g/day) was not diminished by lesions produced at this age. Neither the onset of puberty nor the LH concentration were influenced by lesioning of the AMN on day 26. Estimation of the LH concentration in untreated female rats revealed a distinct decline between 19 and 23 days of age followed by a significant increase between days 24 and 26. The findings indicate a transient LH-inhibiting activity of the medial amygdala in three-week-old female rats that is not related to the negative estrogen feedback. In other species, too, a temporary inhibitory action of the central nervous system may play a significant role in the prepuberal control of gonadotropin secretion.

Aging↗
PubMed1980

Involvement of a cholinergic mechanism in the mediation of hippocampal influences on female sexual maturation and somatic development.

Female Wistar rats were bilaterally lesioned in the anterior part of the ventral hippocampus (VHPC) at 21, 26 or 32 days of age. Irrespective of the age at lesioning a significant delay of vaginal opening and of the first ovulation was recorded. This delay of the onset of puberty was consistently associated with a retardation of the body weight increase. Both the puberty-delaying and growth-retarding effects of VHPC lesions produced on day 21 could be prevented by daily s.c. injections of 50 micrograms/100 g b.w. pyridostigmine from day 21 till vaginal opening, but not by the administration of 2 mg/100 g/day pargyline. The findings suggest a cholinergic mediation of stimulatory effects exerted by the hippocampus on sexual maturation and somatic development.

Animals↗
PubMed1979

[Clinical use and comparative study of Ulmer drainage and of the usual Redon tissue drainage].

After discussing the shortcomings of the usual Redon drainages and the description of our own technique of vacuum-tissue suction drainage, there follows a report about a comparative examination between Redon drainages and the new 'Ulmer drainage'. Up to now the superiority of the Ulmer drainage was proven only by calculation and experiment, now this fact can be fully confirmed by a succession of clinical examinations. By inserting both types of drainages in one surgical wound, the Ulmer drainage delivered on the first day 1.5 times; on the second and third day, almost 2.5 times the amount of secretion compared with the usual Redon drainage.

Clinical Trials as Topic↗