Biomedical subjects

T Larmi

Publications and source records attributed to T Larmi.

17 recordsLinked to original sources

PubMed1988

Prevalence of exfoliation syndrome in Finland.

Three separate investigations are reported, covering a total of 795 patients from different parts of Finland, two of them consisting of inmates of old people's homes in two towns (N = 205 and 262) and one a randomly selected population from a rural commune (N = 328). They show the mean prevalence of exfoliation syndrome (PS) to be 14.2% in age group 60 less than or equal to 69 years, 21.9% in age group 70-79 and 34.7% in age group greater than or equal to 80. The prevalence increases statistically significantly with age. The mean prevalence of PS in all three groups was 22.4%. No isolate-like accumulation of PS could be demonstrated. The figures seem representative of the hole country.

Age Factors↗

PubMed1985

Increased urinary levels of thyrotropin-releasing hormone immunoreactivity in acute pancreatitis.

Thyrotropin-releasing hormone (TRH) has been shown to be present and have actions in the human gastrointestinal tract. We have studied urine TRH immunoreactivity (TRH-ir) levels in healthy subjects and patients with acute pancreatitis, gallstones, ulcerative colitis, or acute gastritis. The urine samples were prepurified by SP-Sephadex-C-25 cation exchange chromatography, subjected to reverse-phase high-pressure liquid chromatography, and assayed in our TRH radioimmunoassay. The mean urine TRH immunoreactivity values of healthy subjects were 4.42 +/- 1 ng/l (x +/- SEM); of patients with acute pancreatitis on the 1st day of hospitalization, 23 +/- 7 ng/l; on the 2nd day, 7 +/- 1 ng/l; and on the 3rd day 9 +/- 2 ng/l. Only the urine TRH levels of the pancreatitis patients on day 1 differed significantly (p less than 0.05) from the levels of the healthy subjects. Circulating TRH appears to be derived mostly from the pancreas, where the islets during acute pancreatitis are affected, and TRH is released into circulation and urine.

Acute Disease↗

PubMed1985

[Common ophthalmic diseases in the elderly].

Explore the source record for details and available documents.

Aged↗

PubMed1984

A comparison between serum ferritin concentration and the amount of bone marrow stainable iron.

There was good parallelism between serum ferritin levels and the amount of bone marrow stainable iron in 123 patients with gastritis, gastric ulcer and duodenal ulcer. A serum ferritin concentration of about 20-25 micrograms/l is the approximate level below which stainable iron cannot be demonstrated in the bone marrow.

Bone Marrow↗

PubMed1984

[Behavior of small molecular cysteine proteinase inhibitors in lung cancers and surrounding tissue].

In this work, we have studied the occurrence of acid and neutral cysteine proteinase inhibitors in 3 histologically different lung cancers. The acid cysteine proteinase inhibitor ( ACPI ) seems to be associated to squamous differentiation as our previous observations have shown. As a new observation we could show that the neutral cysteine proteinase inhibitor ( NCPI ) was localized in alveolar macrophages.

Adenocarcinoma↗

PubMed1976

Effects of ethanol on the cyclic AMP system of the dog gastric mucosa.

The effect of ethanol on the cyclic AMP system of the dog fundic mucosa was studied in vitro. The gastric mucosal content of cyclic AMP was increased by 2.5% ethanol, whereas 10 and 20% ethanol decreased the mucosal content of cyclic AMP. The activity of adenylate cyclase was increased by 2.5 and 5% ethanol, whereas 10% ethanol did not significantly affect it. The activity of cyclic AMP phosphodiesterase was inhibited by ethanol in a competitive manner. The increase in the gastric mucosal content of cyclic AMP, induced by low concentrations of ethanol, is apparently due to the stimulation of adenylate cyclase and inhibition of phosphodiesterase. Changes in the phosphodiesterase or adenylate cyclase activites do not explain the decrease of the mucosal content of cyclic AMP by higher concentrations of ethanol. The mechanism of the decrease is discussed.

3',5'-Cyclic-AMP Phosphodiesterases↗

PubMed1976

Effects of ethyl alcohol on the adenosine 3', 5'-monophosphate system of the human gastric mucosa.

The effect of ethyl alcohol on the cyclic AMP system of the human gastric mucosa was studied in vitro. Corporic gastric mucosa was obtained from patients operated on for gastric or duodenal ulcers. Under the in vitro conditions used, ethanol at concentrations of 5% (v/v) or less stimulated the activity of adenylate cyclase and induced a dose-dependent rise of the gastric mucosal content of cyclic AMP. However, 10% ethanol increased the activity of adenylate cyclase but did not affect the gastric mucosal content of cyclic AMP. At the concentrations of 5 or 10%, ethanol inhibited the activity of cyclic AMP phosphodiesterase in a competitive manner. Reports in the literature indicate that oral ethanol stimulates the output of gastric acid at low but not at higher concentrations. The present results are consistent with the conception that the stimulatory effect of ethanol on the output of acid is mediated by an increase of the content of cyclic AMP in the gastric mucosa.

Adenylyl Cyclases↗

PubMed1974