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T Laskus

Publications and source records attributed to T Laskus.

At least 109 records · Page 6Linked to original sources
PubMed1990

A follow-up study of an outbreak of non-A, non-B hepatitis in a plasmapheresis unit.

A cluster of acute non-A, non-B hepatitis comprising 12 blood donors was diagnosed in a plasmapheresis unit. Nine cases were followed-up for 2-5.5 years and seven out of them progressed to chronicity, as judged by biochemical abnormalities. In six, liver biopsy was performed 1 year after the acute disease revealing chronic active hepatitis in two, chronic persistent hepatitis in two, chronic lobular hepatitis in one and normal liver in one. Repeated biopsies showed progression to cirrhosis in one case of chronic active hepatitis, and resolution of the disease in another one, while in the remaining patients liver morphology remained unchanged. Circumstantial epidemiologic evidence suggests a single agent being the cause of the outbreak, which resulted in a broad spectrum of liver disease.

Adult↗
PubMed1990

Liver disease among Polish alcoholics. Contribution of chronic active hepatitis to liver pathology.

A group of 70 chronic alcoholics--65 men and 6 women--has been studied. HBsAg was found in 11 (16%), and at least one marker of HBV infection was present in sera from 31 (44%) persons, these results being significantly higher than in a matched control population. The commonest single histological patterns were: steatosis (18 cases), and alcoholic hepatitis (18 cases), followed by normal liver (14 cases) and chronic active hepatitis (12 cases). Cirrhosis was diagnosed in only 4 cases. Five cases of chronic active hepatitis could be attributed to infection with HBV or HDV; in the remaining 7 cases the etiology was unclear. Infection with HBV seems to play an important role as the cause of liver disease among alcoholics in Poland, and chronic active hepatitis of various etiology may be an important form of liver pathology among them.

Adult↗
PubMed1990

Short-term corticosteroid therapy for chronic active hepatitis B.

Seventeen patients with chronic active type B hepatitis were treated with prednisone for 4 weeks. All were initially hepatitis B e antigen (HBeAg)-positive and 14 were DNA-polymerase-positive as well. In the follow-up period of 1 year, 10 patients became persistently negative for DNA polymerase and 11 cleared HBeAg from serum, while among 17 matched untreated controls only one lost DNA polymerase and HBeAg. However, 1 patient who was initially DNA-polymerase-negative and who lost HBeAg after treatment reactivated to HBeAg after 4 months and DNA polymerase appeared in his serum. He suffered prolonged exacerbation of liver disease after treatment and died of liver failure. Short-term corticosteroid therapy may be of value in patients with chronic active type B hepatitis, however, in some cases such treatment may be disastrous.

Adult↗
PubMed1990

Cytomegalovirus infection presenting as hepatitis.

Among 530 consecutive patients hospitalized for acute hepatitis in the years 1986-1988 cytomegalovirus infection was diagnosed in 5 (0.9%). All 5 patients had symptomatic hepatitis with jaundice, 3 had pruritus. Hematological changes were relatively mild and liver function tests were not essentially different from those found in patients with hepatitis A, B, or non-A, non-B. All biochemical abnormalities returned to normal within 3-5 weeks.

Adolescent↗
PubMed1990

Isoprinosine in the treatment of chronic active hepatitis type B.

21 patients with chronic active hepatitis B (CAH-B) were treated for 1-2 years with isoprinosine, while another 18 patients served as control group. All patients were initially DNA polymerase (DNAp) and HBeAg positive. Nine (43%) treated patients became persistently negative for DNAp, seroconverted to anti-HBe and showed histological remission on follow-up biopsy. Among simultaneously followed controls 5 (28%) lost DNAp and 4 (22%) also lost their HBeAg. However, only 2 (11%) seroconverted to anti-HBe. Histological improvement was seen in 5 (28%) controls. Thus, it seems that isoprinosine may exert a beneficial effect on the course and outcome of CAH-B.

Adult↗
PubMed1989

[Course of acute hepatitis B in alcoholism].

Clinical course of the acute hepatitis B has been analysed in 29 men chronically abusing alcohol. The most frequent source of the infection was surgery and hospitalizations. Clinical course and biochemical findings were similar in this group and in 30 men not drinking alcohol. A sole difference concerned higher GGTP activity in alcoholics. The persistence of HBs antigen was similar in both groups. Chronic alcohol abuse does not seem to have a significant effect on the course and convalescent phase of the acute hepatitis B.

Acute Disease↗
PubMed1989

[Severe alcoholic hepatitis].

A case of severe alcoholic hepatitis was observed in a man aged 30 years. Attention is called to possible diagnostic and therapeutic difficulties. Despite abstinence lasting 9 months the results of biochemical tests failed to return to normal values.

Adult↗
PubMed1989

[Liver damage in alcoholics].

The authors made a liver biopsy in a group of 42 persons chronically abusing alcohol. In the majority of patients the authors found various forms of hepatopathology: fatty degeneration--8 cases (19%), alcoholic hepatitis--10 cases (24%), chronic active hepatitis--11 cases (26%), and hepatocirrhosis--2 cases (5%). The authors found no correlation between the kind and degree of liver damage and the amount of alcohol drunk, which suggests the role of individual hypersensitivity in the development of hepatopathology in alcoholics. In some of the alcoholics liver damage was connected with infection by HBV--5 cases (12%) and the participation of alcohol in the pathogenesis of chronic active hepatitis seems likely but it still remains not verified. The results of the investigation carried out point to the need of histological examination of the liver in alcoholics.

Adult↗
PubMed1989

[Delta infection in various forms of hepatitis B].

Blood serum of 126 patients infected by HBV was studied for the presence of anti-delta antibodies. They were found in 8 patients (6.3%): in 5 out of 99 cases of chronic hepatitis in non-drug-addicts and in 3 out of 4 drug-addicts. No delta antibodies were found in 20 HBV carriers or 3 cases of supra-acute hepatitis. The disease in delta virus infected patients had a more severe course, often accompanied by the lack of active replication of HBV. The results of the examinations show to the presence of delta virus infections in Poland.

Acute Disease↗
PubMed1988

Prevalence of hepatitis B virus markers among Polish urban alcoholics.

124 consecutive patients (mean age: 41.1 years; range: 20-63 years) attending an outpatient alcoholic clinic were tested for the presence of markers of HBV infection. HBsAg was found in 26 (21%), anti-HBs and/or anti-HBc in the absence of HBsAg in 35 (28%). Altogether, at least one marker was present in 61 (49%), these results being significantly higher than in a matched control population. In 70 cases HBV status was compared with epidemiological data. No relationship was found with past blood transfusions, hospitalization or jaundice. HBV infection was, however, more common when parents of the subjects were alcoholics, which points to a possible role of family spreading. Furthermore, chronic infection with HBV was related to high alcohol intake.

Adult↗
PubMed1988

Prevalence of hepatitis B virus markers among Polish alcoholics.

102 consecutive alcoholics attending an outpatient alcoholic clinic were tested for hepatitis B virus (HBV) markers in serum. HBsAg was found in 21, anti-HBs in 22 and anti-HBc in 42; at least 1 marker was present in 49. These results were significantly higher than in a matched control population. Out of 21 HBsAg positive cases 7 had markers of ongoing viral replication as judged by the presence of HBeAg and HBV DNA.

Adult↗