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Biomedical subjects

T Lindberg

Publications and source records attributed to T Lindberg.

At least 19 recordsLinked to original sources
PubMed1992

Increased protein absorption after acute gastroenteritis in children.

We investigated the intestinal absorption of the macromolecule human alpha-lactalbumin during and after an episode of acute gastroenteritis in children. Twenty children were studied in the acute phase and 17 excreted rotavirus. Eleven children were studied again 5-8 weeks later (convalescent phase). Human alpha-lactalbumin serum concentrations in the acute phase were similar but in the convalescent phase they were significantly (p less than 0.001) higher than those in the reference children. The serum concentrations were also higher in the convalescent than in the acute phase (p = 0.021). This study suggests that there is an increased absorption of proteins from the gut into the circulation 5-8 weeks after rotavirus gastroenteritis.

Acute Disease↗
PubMed1992

Increasing incidence of childhood coeliac disease in Sweden. Results of a national study.

A survey of the incidence of coeliac disease was carried out by asking all 43 paediatric departments in Sweden to report the number of children born between 1978 and 1987 in whom coeliac disease had been diagnosed. Thirty-four departments representing a population of 7.18 million reported 1944 cases of coeliac disease among 804,935 children born between 1978 and 1987. The cumulative incidence of coeliac disease was 1.7 per 1000 live births in children born between 1978 and 1982 and doubled to 3.5 per 1000 live births in children born after 1982. The highest incidence was found in the southern and south-eastern regions of the country. The observed increase may have been influenced by changes in infant feeding practices such as the postponed age of introduction of gluten from four to six months of age and an increase in gluten content of proprietary baby foods.

Celiac Disease↗
PubMed1991

Pain relief in infants after major surgery: a descriptive study.

Twenty subjects (nurses or parents) were interviewed concerning postoperative pain and pain relief in infants. Details of postoperative analgesics given were obtained from hospital records of 32 infants, aged 0 to 12 months, who had undergone major surgery, and routines for postoperative pain relief in infants were investigated at four Swedish hospitals where major surgery is performed on infants. Although both nurses and parents were found to be able to recognize postoperative pain reactions in infants, attitudes to pain relief were not uniform. In principle, postoperative pain relief is given "as required," although both dosage and intervals between doses are arbitrary.

Analgesics↗
PubMed1991

Macromolecular absorption and cows' milk allergy.

The absorption of macromolecules was analysed by measuring serum concentrations of human alpha-lactalbumin after feeding human milk, using a competitive radioimmunoassay. The control group consisted of 78 children fed by cows' milk formula; concentrations of alpha-lactalbumin in their serum were low. The median concentrations in the different age groups varied between 7-13 micrograms alpha-lactalbumin/1 serum/1 human milk/kg body weight. Twenty-eight children with cows' milk allergy were studied before introduction of a diet free of cows' milk. Nineteen had gastrointestinal and nine skin symptoms. High serum alpha-lactalbumin concentrations were found. Only two children had alpha-lactalbumin concentrations below 100 micrograms alpha-lactalbumin/1 serum/1 human milk/kg body weight. Altogether 76 children on a diet free of cows' milk were studied directly after a cows' milk challenge; 26 developed symptoms. They had significantly higher serum alpha-lactalbumin values than the 50 children with no symptoms upon challenge. Eighteen of the 26 children with symptoms had serum alpha-lactalbumin concentrations of more than 100 micrograms/1 serum/1 human milk/kg body weight in contrast with two of the 50 with no symptoms. Total serum IgE antibodies were analysed in 43 children. No correlation was found between concentrations of serum IgE and serum alpha-lactalbumin in the children with cows' milk allergy.

Animals↗
PubMed1990

Motilin and infantile colic. A prospective study.

Two hundred and nineteen infants, consecutively born, took part in a prospective study of infantile colic from birth to 12 weeks of age. The prevalence of infantile colic in this group was 17.4%. S-motilin was studied in 78 term infants (19 with and 59 without infantile colic) at birth (cord blood), at one day, and at 6 and 12 weeks of age, respectively. Basal motilin levels were raised both in cord blood (p less than 0.01) and in blood from neonates (p less than 0.001) who developed colic as well as in 6 week (p less than 0.05) and in 12-week-old infants with colic (p less than 0.01). Formula-fed infants with colic had higher basal motilin levels than formula-fed controls at 6 and 12 weeks of age (p less than 0.05). Breast-fed infants with colic had higher basal motilin levels than breast-fed controls at 12 weeks of age (p less than 0.05). The raised levels of motilin from the first day of life in infants who develop infantile colic might indicate that the gastrointestinal tract is affected in infants with infantile colic, before any symptoms of colic appear.

Colic↗
PubMed1990

Macromolecular absorption in infants with infantile colic.

Intestinal absorption of macromolecules, using human alpha-lactalbumin (alpha-LA) as a marker, was studied in breast-fed and formula-fed infants with infantile colic. Serum samples taken at 30 and 60 min after an intake of human milk were analyzed for alpha-LA by a competitive radioimmunoassay technique. Breast-fed infants with infantile colic had significantly higher s-alpha-LA levels compared with age-matched breast-fed control infants 0-1 month of age: median value 926 micrograms alpha-LA/l serum/l human milk/kg bodyweight (n = 11) versus 150 (n = 34); 1-2 months of age: 173 (n = 22) versus 31 (n = 16); 2-3 months of age: 132 (n = 8) versus 11 (n = 16). Similarly, formula-fed colicky infants had significantly higher s-alpha-LA levels than age-matched formula-fed control infants 1-2 months of age: median value 126 (n = 12) versus less than 10 (n = 14); 2-3 months of age: 156 (n = 11) versus less than 10 (n = 10). The increased absorption of the macromolecule human alpha-lactalbumin in infantile colic suggests that the gut mucosa is affected in infants with infantile colic.

Animals↗
PubMed1989

Macromolecular absorption in preterm and term infants.

Human alpha-lactalbumin (alpha-LA) has been used as a marker for measuring macromolecular absorption. The serum concentration of human alpha-LA after a human milk feed has been studied in 32 healthy very low birthweight infants (VLBW), fed human milk (gestational age 26-32 weeks) and in 56 term, breast-fed infants, age 3-140 days. At 31 weeks of gestation the serum concentration of human alpha-LA was more than 10 times higher (mean value 3,000 and median value 2,101 micrograms/l serum/l human milk/kg body weight, n = 11) than in the term infants aged 3-30 days (mean value 257 and median value 152, n = 29). The serum concentration of alpha-LA decreased with increasing maturity in the VLBW-infants. At a postconceptional age of 37 weeks the values were similar (mean value 200 and median value 99, n = 8) to those found for term infants during the first month. In the term infants a decreasing absorption of alpha-LA was found with increasing postnatal age.

Female↗
PubMed1989

Cow's milk whey protein elicits symptoms of infantile colic in colicky formula-fed infants: a double-blind crossover study.

There are several causes of infantile colic. The aim of this study was to evaluate, under controlled conditions, whether bovine whey proteins can elicit symptoms of infantile colic in colicky formula-fed infants. The mean age for entering the study was 6.4 weeks and the mean age for colic debut was 3.7 weeks. In 24 of 27 infants with severe colic, the symptoms disappeared when they were given a cow's milk-free diet (Nutramigen). These 24 infants were entered into a double-blind crossover study. The infants (receiving cow's milk-free diet) were given the contents of identical capsules with each meal during day 6. The same procedure was repeated on day 10. The capsules contained either whey protein powder (with Nutramigen added) or human albumin powder (with Nutramigen added). Eighteen infants receiving the whey protein-containing capsules reacted with colic, two infants receiving placebo reacted with colic (P less than .001), and four infants did not react at all. Crying hours per day for the 24 infants were 5.6 hours for formula-fed infants and 0.7 hour for cow's milk-free diet-fed infants (P less than .001). Crying hours per day were 3.2 hours for the infants receiving whey protein capsules and 1.0 hour for those receiving placebo (P less than .001). In conclusion, bovine whey protein can elicit symptoms of infantile colic in colicky formula-fed infants.

Animals↗
PubMed1988

Male pseudohermaphroditism due to 5 alpha-reductase deficiency in a Swedish family.

Three sibs with an inherited form of male pseudohermaphroditism are described. They were all born with ambiguous external genitalia but no diagnosis of a possible enzyme defect was made during childhood. First seen at the ages of 16, 14 and 10 years respectively, they were investigated in order to establish the pathogenetic nature of the disorder. Serum concentrations of testosterone and dihydrotestosterone before and after stimulation with human chorionic gonadotropin suggested 5 alpha-reductase deficiency. Measurement of steroid metabolites in urine confirmed this diagnosis. It is essential to recognize this condition in order to decide the sex of rearing of the children.

Adolescent↗
PubMed1987

Immunoreactive anionic trypsin and anionic elastase in human milk.

Immunoreactive anionic trypsin and anionic elastase have been demonstrated in human milk, by immunodiffusion and immunoelectrophoresis. Cationic trypsin and cationic elastase could not be detected by these methods. The anionic trypsin is probably present in complex with IgA. No benzoyl-DL-arginine-p-nitroanilide (BAPNA) splitting activity was found in human skim milk. Anionic trypsin was isolated by immunoadsorption chromatography. The purified enzyme had a BAPNA-splitting activity.

Anions↗
PubMed1987

Motilin, vasoactive intestinal peptide and gastrin in infantile colic.

Intestinal hyperperistalsis is one part of the clinical picture in infantile colic. Three gut hormones involved in the regulation of gut motility; motilin, vasoactive intestinal peptide (VIP) and gastrin, were measured with the RIA method in: 40 infants with infantile colic, (age 2-22 weeks), 42 healthy age-matched infants, 11 children (age 3-36 months) with gastrointestinal disorders, and 20 children (age 3-36 months) with non-gastrointestinal disorder. Basal s-motilin levels were raised in infants with infantile colic (p less than 0.01) and in children with other gastrointestinal disorders (p less than 0.001). Formula-fed infants had higher basal s-motilin levels than the breast-fed infants (p less than 0.05). P-VIP and s-gastrin levels were raised in children with other gastro-intestinal disorders (p less than 0.05), but not in infantile colic. Formula-fed colicky infants had higher s-gastrin levels than the breast-fed colicky infants (p less than 0.05). We suggest that the increased s-motilin level in infantile colic might account in part for the clinical picture of this disorder.

Bottle Feeding↗
PubMed1986

Coeliac disease in children of short stature without gastrointestinal symptoms.

Eighty-seven children with short stature (height more than 2 SD below the mean for age and sex) were investigated by small intestinal biopsy. There was no obvious reason for their growth retardation found by routine examination and they had no gastrointestinal symptoms. Coeliac disease was found in two children and probable coeliac disease in two children. Although the prevalence of coeliac disease was comparatively low in this study of Swedish children with short stature, it emphasizes the fact that coeliac disease must be considered in a child with short stature even in the absence of gastrointestinal symptoms.

Adolescent↗
PubMed1986

Bovine beta-lactoglobulin in the human milk. A longitudinal study during the whole lactation period.

Human milk samples (n = 232) collected during the whole lactation period from 25 healthy, Swedish mothers were analyzed by radioimmunologic method for content of bovine beta-lactoglobulin. Detectable amounts (5-800 micrograms/l) were found in 93 of 232 milk samples (40%). Six mothers had no detectable beta-lactoglobulin in their breast milk on any occasion. Two mothers had measurable beta-lactoglobulin in all their milk samples. No correlation was found between daily cow's milk intake and concentration of beta-lactoglobulin in the milk samples. Six mothers with allergic symptoms such as asthma, hay-fever, eczema all had detectable amounts of beta-lactoglobulin in their milk. Of 19 mothers without allergy, 13 had detectable amounts. This difference did not show statistical significance. The presence of symptoms in the infant such as diarrhoea, vomiting, colic, exanthema was significantly correlated to high levels of beta-lactoglobulin in the milk. Bovine beta-lactoglobulin was also detected in 7 of 13 serum samples. The two mothers with detectable beta-lactoglobulin in all milk samples had the highest serum values, and their infants suffered from gastro-intestinal symptoms, weight decline and exanthema.

Animals↗
PubMed1986

Hospital routines in infants with hyperbilirubinemia influence the duration of breast feeding.

Twenty-nine infants undergoing phototherapy to treat hyperbilirubinemia were divided into two groups. One group of mothers (non-separated) were transferred with their infants to the paediatric ward and remained as the primary care provider. The other group of mothers (separated) remained on the maternity ward and went to the paediatric unit to care for their infants at feeding times. A third group of healthy mothers and infants served as controls. Mothers in the non-separated group were more satisfied with the care than mothers in the separated group. The duration of breast feeding in the separated group was significantly shorter than in the other groups. The urine cortisol levels in the separated mothers were the same at one week and three months after delivery. The mothers in the other two groups had significantly higher urine cortisol levels during the first week postpartum than three months postpartum. We conclude that routine phototherapy for jaundiced infants should not separate mothers and infants.

Breast Feeding↗