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Biomedical subjects

T Livraghi

Publications and source records attributed to T Livraghi.

At least 73 records · Page 4Linked to original sources

US-guided percutaneous alcohol injection of small hepatic and abdominal tumors.

Fourteen lesions (nine hepatocellular carcinomas, four hepatic metastases from gastric carcinoma, and one peritoneal metastasis from transitional cell carcinoma) in 12 patients were treated with percutaneous injection of 95% ethyl alcohol under guidance with ultrasound. Requirements for this procedure included inadequate response to conventional treatment or refusal of surgery, easy identification of the tumor with sonography, and a tumor diameter less than 4 cm. Three to nine administrations (75 in all) were performed for each lesion according to its size and to the results of the fine needle biopsy. All lesions had posttreatment sonographic structural changes of fibronecrotic degeneration. All lesions less than 3.2 cm in diameter (11 cases) that underwent the final fine needle biopsy were negative for malignant cells and had volume reductions up to 100%. No biochemical changes or untoward clinical sequelae were detected. Percutaneous intratumoral alcohol injection is inexpensive, easy to perform, and potentially valuable in the treatment of selected small neoplastic lesions of the liver and abdomen.

Adult↗

Diagnosis of hydatid cyst by percutaneous aspiration: value of electrolyte determinations.

A study was made of the fluid from 11 hydatid cysts (10 hepatic, one renal) and from 50 nonparasitic cysts (25 renal, 10 ovarian, 10 pancreatic and five hepatic). Our analysis indicated that the chloride (range 62-95 mEq/liter), the sodium (range 125-139 mEq/liter) and the potassium content (range 5.1-7.5 mEq/liter) of the former differed significantly (p less than 0.01) from those of the controls. Hydatid cysts may be indistinguishable from others with both CT and ultrasound and therefore the electrolyte data are of diagnostic value when a hydatid cyst is accidentally punctured percutaneously.

Biopsy, Needle↗

Fine-needle biopsy of hepatic hemangioma with sonographic guidance.

Thirty-three focal hepatic lesions later proven to be hemangiomas underwent sonographically guided fine-needle aspiration biopsy. Indications for cytologic assessment were an atypical sonographic pattern in 11 cases, the need to differentiate from liver metastases in 12 patients with a history of neoplasm, and other indications in 10. The aspirated material consisted of blood alone in 24 cases; in the other nine cases, endothelial cells and/or agglomerates of capillaries were demonstrated also, and this was considered to be diagnostic. In one case, intratumoral bleeding was demonstrated sonographically, but no treatment was needed. The possible angiomatous nature of an hepatic lesion should not be considered an absolute contraindication to biopsy, provided that a fine needle is used and the optimal route to the lesion is chosen.

Adult↗

Inclusion-cytology versus smear-cytology in fine needle abdominal biopsy.

1568 patients underwent percutaneous fine needle biopsy (22-23 g. Chiba). 761 of these had histologic type confirmation of malignant disease. Among the latter, 313 cases had adequate samples retrieved from the same lesion for smear cytology (SC) and inclusion cytology (IC), 400 for SC alone (378 performed before the use of IC) and 48 for IC alone. SC was stained by Papanicolaou and MGG, IC by haematoxylin-eosin technique. In SC + IC group typing accuracy was 0.64 for SC and 0.86 for IC, in SC group was 0.66, in IC group was 0.87. IC permitted an easier preparation and interpretation of special stains. In conclusion, IC routine is recommended. Some interesting observations were possible because material was collected from three hospitals.

Abdomen↗

Smear and inclusion cytology in Chiba-needle aspiration biopsy of hepatic tumors.

183 patients underwent fine-needle liver biopsy with a Chiba 22-gauge needle for suspected neoplasia, and the specimens were prepared for smear and inclusion cytology. 149 patients were controlled and 106 were true positives. Of these, 79 yielded material suitable for both methods, which could thus be compared. The results showed that inclusion cytology improves the typing accuracy for the diagnosis of well-differentiated primary liver tumors. Further, specimens for embedding can be obtained with ordinary Chiba 22-gauge needles which are normally used only for obtaining material for smear cytology.

Adenocarcinoma↗

Focal fatty liver change by sonography.

Focal fatty liver change (FFLC) is a poorly characterized entity whose ultrasound pattern has not yet been properly defined. From our experience based on 12 cases and from the few cases reported in the literature, the following conclusions can be made: (1) FFLC can be of increased and decreased echogenicity with map-like or clearcut margins; (2) rounded lesions with defined margins are indistinguishable from other focal pathology; according to the case, fine needle biopsy, arteriography, computed tomography or nuclear scan should be used; (3) FFLC can change in size or disappear in a short span of time, and (4) a hypoechogenic area with map-like margins in the quadrate lobe (even if it turns out to be a false focal defect in that it corresponds to residual normal liver tissue) of a patient with abnormal values for gamma-glutamyltransferase (GGT) and serum glutamic oxaloacetic transaminase (SGOT) is reasonably indicative of FFLC.

Fatty Liver↗

Combined modes of imaging for liver hemangioma in cancer patients.

Twenty-nine consecutive patients with single or multiple liver hemangioma were assessed with more than one mode of imaging. Static scanning with 99Tcm was done in 21, ultrasonography in 28, CT in 29 and angiography in 27. Fine-needle percutaneous biopsy was unwisely performed in 7 cases with a single but singular complication, severe peritoneal lymphorrhea. Four laparotomies and 2 laparoscopies completed the investigations. Fourteen patients had a history of primary cancer, and 3 of these had a secondary coexisting with the angioma. CT was characteristic; ultrasonography was sensitive and perhaps specific enough for small angiomas. The 2 combined plus angio-CT greatly reduce the need for hepatic angiography.

Angiography↗

[Echography and percutaneous fine needle biopsy].

Echography, even if it is a procedure widely used in numerous protocols, is not devoid of diagnostic inaccuracy. However, when fine needle percutaneous biopsy is associated to echography, the diagnostic accuracy raises to 88%. This combined procedure is easily carried out, it is inexpensive, without discomfort to the patient and devoid of major complications. When it is performed, other more invasive techniques, such as arteriography or laparotomy may be useless. Methods of application and case-reports are illustrated.

Adenocarcinoma↗

[Fine needle biopsy with ultrasound guidance: 263 cases (author's transl)].

The combination between ecography and fine needle aspiration biopsy has greatly speeded up diagnostic procedures. Often this technique is better than other more invasive and expensive investigations, such as angiography and laparotomy, for its high diagnostic accuracy, the limited upsetting of the patient, the absence of serious complications and the simplicity to perform it. Here are some information on the technique, on the indications and on the complications of the procedure. The results of 263 cases of abdominal biopsy are presented.

Abdominal Neoplasms↗