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T Lobera

Publications and source records attributed to T Lobera.

16 recordsLinked to original sources
PubMed2006

Immediate hypersensitivity to corticosteroids.

INTRODUCTION: In comparison with the extremely frequent use of corticosteroids in different diseases, immediate allergic reactions remain uncommon. In addition to the steroid molecule, the causative agent of these reactions can be an excipient. MATERIAL AND METHODS: We report seven cases of immediate reactions induced by different preparations of corticosteroids. Skin tests with the suspected steroid and excipients were carried out. In patients with negative skin tests, oral or parenteral challenges were performed with the drug and the excipients involved. Challenge tests with at least two other corticosteroids belonging to another or even the same group of the Coopman classification were carried out. RESULTS: Of the 7 patients, six had positive skin tests with the suspected preparation of corticoid: three cases with methylprednisolone acetate, two cases with carboxymethylcellulose and one case with the complete triamcinolone preparation. Only in one case did we have to challenge with the suspected steroid preparation to confirm the diagnosis. All challenge tests with other corticosteroids belonging to another or to the same group of the Coopman classification were negative. CONCLUSIONS: The reactions were caused by the steroid molecule (Triamcinolone or methylprednisolone succinate) in four patients, by an excipient (carboxymethylcellulose) in another two patients and we could not identify the sensitized molecule in one patient. We did not demonstrate cross-reactivity between different corticosteroids.

Adrenal Cortex Hormones↗
PubMed2005

Immediate hypersensitivity to quinolones: moxifloxacin cross-reactivity.

INTRODUCTION: Immediate hypersensitivity reactions to quinolones are rare. Moxifloxacin is an quinolone chemically different from other fluoroquinolones. We report 6 patients diagnosed with hypersensitivity to different fluoroquinolones in whom the response to moxifloxacin and cross-reactivity with other quinolones was studied. MATERIAL-METHODS: An allergenic study was made by prick and intradermal test with different fluoroquinolones, in all the patients. Single blind oral challenge tests were performed with moxifloxacin in all the patients, with ciprofloxacin in five patients, with levofloxacin in three patients and with ofloxacin in one patient. RESULTS: The skin test performed with moxifloxacin was positive in five patients, and the oral challenge test was positive in all six patients. All the patients had at least one positive skin test with some of the other fluoroquinolones. CONCLUSION: The skin test with different quinolones seems to be sensitive at showing group hypersensitivity, but not at predicting specific tolerance of each drug. We found a high degree of cross-reactivity among fluoroquinolones, so we currently recommend to avoid the group. We did not find that moxifloxacin differed from other fluoroquinolones so we cannot recommend it as a valid therapeutic alternative in patients sensitized to other quinolones.

Adult↗
PubMed2005

Occupational asthma caused by white mushroom.

The commercial growing of white mushroom (Agaricus bisporus) is a frequent activity in certain Spain regions as La Rioja. We report two cases of white mushroom workers suffering from asthma caused by hypersensitivity to basidiocarp and spores of white mushroom.

Adult↗
PubMedDate not supplied

Carbuterol, salbutamol and DSCG in exercise-induced asthma.

We decided in this work to evaluate the prophylactic value of carbuterol in exercise-induced asthma (EIA), comparing this drug to salbutamol and DSCG in order to describe its usefulness in exercise-induced asthma, while employing the closing-pressure method for the early detection of airway constriction. The study involved 44 bronchial asthmatics with prior histories of EIA. Only 10 patients had noticeable symptoms after exercise. All patients were asymptomatic and without any medication for at least one week prior to the commencement of the study. A continuous running treadmill was chosen for the exercise test, and a 10 minute time-period with a maximum heart rate of 180 beats/min. was the limit. Measurements of the FEV1, PEF and Raw were also done. Drug therapy was carried out by administering 10.5 mg of carbuterol, or 4 mg of salbutamol orally, 1.5 hours, before the exercise, or a 20 mg DSCG capsule, 30 minutes also prior to exercise. We concluded that: DSCG is the drug of choice in the control of EIA, while salbutamol results were somewhat less effective. Orally administered carbuterol did not provide any protection effect as expected. Raw measurements enter as a new parameter for consideration in this type of disease, being entirely compatible with FEV1 and PEF values during assessment.

Airway Resistance↗
PubMedDate not supplied

Standardized values of lower airway resistance in healthy individuals.

One hundred and seventy eight healthy individuals, smokers and non-smokers of both sexes were studied, grouping them according to the parameters of age, height, weight and body surface, with the aim to prepare a standard table of airway resistance. The method was performed with the apparatus APTA (Jaëger) based upon the closing pressure technique. Regarding resistance, the average value obtained was 0.66790 Kpc/L/sec-1 with a standard deviation of 0.26773. With respect to the statistical study, no significant correlations were found among the parameters of sex, age, weight, body surface and smoking habits in relation with airway resistance. Nevertheless, we obtained an inverse significant correlation between variables of height and airway resistance. As a consequence, a study of linear correlation was done between height and airway resistance, bringing about the correlation coefficient such as the equation of linear regression wherein we obtained the lines of regression and the formula of the equation.

Adolescent↗
PubMedDate not supplied

Airway resistance in bronchial asthma and rhinitis.

Following the acceptance of the interrupter technique as one of the most sensitive in determining airway resistance, we decided to conduct a comparative study between healthy subjects and those patients with respiratory illness, in the varieties rhinitis and bronchial asthma. The study included 125 patients with respiratory illness, 42 diagnosed as having rhinitis and 83 with bronchial asthma with or without associated rhinitis. These groups were divided into symptomatic and asymptomatic at the time of the study. Hundred and eighty individuals were selected as a control group. A significant difference can be seen between the values for airway resistance of the control group (means = 0,651 7 kpc/l./sec.-1) and those with symptomatic rhinitis (means = 0,7732 kpc/l./sec.-1) or symptomatic bronchial asthma (means = 1,2602 kpc/l./sec-1). Values for airway resistance in asymptomatic patients (rhinitis and bronchial asthma) are similar to the control group. The rhinitis group which was clinically symptomatic at the beginning of the study was divided into two groups according to whether the airway resistance was within +/- 1 standard deviation of the mean or elevated analysis showed a statistical difference between the two groups. This makes us think that we are dealing here with distinct groups.

Airway Resistance↗
PubMedDate not supplied

T helper and T suppressor subpopulations in pollinosis. Effect of specific immunotherapy.

In this work, possible alterations in OKT-4+ and OKT-8+ cells in relation to pollinosis in studied, 33 pollinic patients were studied. 11 of these had not received immunotherapy and the rest had been treated with specific immunotherapy. The possible effect of immunotherapy on the T helper/T suppressor ratio is evaluated. No significant differences between the two groups of patients were found neither in relation to duration of immunotherapy nor in relation to the control group.

Desensitization, Immunologic↗
PubMedDate not supplied

Study of lymphocyte subpopulations in contact dermatitis by sensitization to chrome and/or nickel.

Contact dermatitis is a hyperergic reaction mediated predominantly by T lymphocytes in which the target tissue is the skin. In this way and taking as a starting point that contact dermatitis is a reaction typically mediated by T lymphocytes, our aim is to study the possible existence of an unbalance between the lymphocyte subpopulations OKT-4+ and OKT-8- (T mu and T gamma) in comparison to a normal population and if, on the other hand, any of these subpopulations are involved in the increase of lymphocytes that form E active rosettes. We can see that there are no significant variations with regard to the number and function of the lymphocyte populations in individuals with contact dermatitis when we compare them to a control group. On the other hand, we consider it very important to emphasize that we have failed to detect differences in the parameters of lymphocyte populations and subpopulations studied before and after contact with the causal antigen responsible for the cutaneous condition.

Chromium↗
PubMedDate not supplied

Dose-response curves for lymphoblast transformation by phytohemagglutinin stimulation.

In order to seriously evaluate the lymphoblast response to PHA, we studied the effects of different doses of the mitogen and different culture periods in the normal population. According to our results, we classified the subjects into 2 groups, high responders and low responders. No significant differences were found among the groups in the spontaneous blast transformations. Maximum levels of stimulation were obtained with PHA doses of 2 to 10 micrograms/10(5) cells/100 microliters. Maximal response in the high responder group was observed on the fifth day of incubation, whereas for low responders, maximum stimulation was observed on the third day of incubation. Two populations responding with different intensity to PHA were identified, suggesting that the different responses were conditioned by genetic factors. The interpretation of the lymphoblast response to phytohemagglutinin is a much more complex task than is currently believed. The variations in response may result from alterations in the immune system as well as from the peculiar genetic characteristics of each individual.

Adolescent↗
PubMedDate not supplied

Immunotherapy with a standardized Dermatophagoides pteronyssinus glutaraldehyde-modified extract against an unmodified extract: a comparative study of efficacy, tolerance and in vivo and in vitro modification of parameters.

We comparatively studied clinical efficacy, tolerance and modifications of different in vivo and in vitro parameters induced by two biologically standardized Dermatophagoides pteronyssinus extracts (HEP units), one glutaraldehyde-modified, in patients with allergic rhinitis and/or bronchial asthma after a year of treatment. A decrease in drug consumption was observed in both treatment groups (p < 0.0001). Of all the in vivo parameters studied (cutaneous, conjunctival and bronchial reactivity to the allergen), a decrease in specific bronchial reactivity was only observed in the group treated with the modified extract (p < 0.05). The modifications in total IgE, specific IgE and specific total IgG levels are superimposable on those described in previous papers on immunotherapy. However, IgG4 levels remained stable with respect to time. Tolerance was good and very similar for both treatments; both types of extracts are equally efficacious and safe.

Adolescent↗