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T Lubrano

Publications and source records attributed to T Lubrano.

34 records · Page 2Linked to original sources
PubMed1978

E1k, another quantitative variant at cholinesterase locus 1.

Two families segregating for the atypical (E1a) allele at cholinesterase locus 1 are described. Unusual results for dibucaine inhibition led to the recognition of a new allele (E1k) also segregating in these families. The enzymatic and immunological data are consistent with the hypothesis that E1k causes reduction of 'usual' (E1u) molecules by about 33%. Whether the reduction of E1u caused by E1k is caused by retarded synthesis or accelerated degradation of serum cholinesterase remains to be determined.

Cholinesterases↗
PubMed1976

New allele at cholinesterase locus 1.

A family (H-J pedigree) segregating for the A and F alleles at cholinesterase locus 1 is described. Apparent anomalous results led to the recognition of a new allele (E1j) also segregating in the family. The data are consistent with the hypothesis that the the E1j causes reduction of 'usual' (E1u) molecules by about 66%. Whether this is because of retarded synthesis or accelerated degradation of serum cholinesterase remains to be determined.

Alleles↗
PubMed1976

E1j, a quantitative variant at cholinesterase locus 1: immunological evidence.

Sera of various phenotypes at serum cholinesterase locus 1, including the newly recognized phenotypes E1 aE1j, E1 uE1j, and E1 fE1J, were studied by immunodiffusion and rocket immunoelectrophoresis. The sera containing the E1j allele show reduced numbers of immunologically active cholinesterase molecules. This finding is consistent with the previously advanced hypothesis that E1j results in reduced numbers of circulating 'usual' (E1u) molecules. Whether this reduction is the result of the low rate of synthesis or of an increased rate of degradation of the cholinesterase remains to be determined.

Alleles↗
PubMed1970

Silent cholinesterase gene: variations in the properties of serum enzyme in apparent homozygotes.

The cholinesterase activity of the sera of 25 subjects diagnosed as homozygotes for the silent cholinesterase gene was studied by a sensitive enzymatic method employing several thiocholine esters and various inhibitors, and by disc electrophoretic, immunochemical, and chromatographic methods.(a) With one exception, the sera fell into two classes by all criteria. One class (type I, 16 cases) had no normal serum cholinesterase. The other class (type II, eight cases) had about 2% of apparently normal serum cholinesterase. The remaining serum was intermediate between the two classes in several respects. One explanation for these results is that there are several "silent" genes concerned; possibly these are allelic.(b) Normal sera and all silent sera contain small amounts of a cholinesterase activity labeled the residual cholinesterase. The enzyme(s) responsible has properties similar to those of acetylcholinesterase rather than serum cholinesterase. It is estimated that about 1% of the activity of normal serum against acetylthiocholine is due to this enzyme. The source of the residual cholinesterase is not yet known.

Cholinesterases↗
PubMedDate not supplied

[Inguinal hernia containing bladder and ureter. A clinical case].

The authors describe an uncommon case of inguinal hernia with bladder and ureter content. Bladder herniation preoperative diagnosis has been achieved by means of clinical history, objective and instrumental examination (cystography). As usually happens, ureteral herniation was a chance finding; this could involve a trick in surgery setting up and doubts in the treatment methods.

Aged↗