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T M Fabian

Publications and source records attributed to T M Fabian.

7 recordsLinked to original sources
PubMed1982

Stability of sodium hypochlorite solutions.

The stability of diluted solutions of sodium hypochlorite was studied. Sodium hypochlorite 1% solutions were diluted (1:8, 1:12, and 1:20) and stored at room temperature in a window exposed to sunlight in amber-glass, two-liter bottles that were two-thirds full. Samples were taken 25 times throughout a six-month study period; bottles were opened only on sampling days. An iodometric titration was used to determine the percent available chlorine in each sample. Least-squares regression analyses of the percent available chlorine yielded lines with negative slopes for each dilution (-7.7 X 10(-6), -8.1 X 10(-6), and -1.5 X 10(-6) for the 1:8, 1:12, and 1:20 dilutions, respectively). Using the fastest degradation rate (from the 1:12 dilution), 5.24% of available chlorine would be lost per year. The concentration of sodium hypochlorite would therefore remain above 90% of the initial concentration for 22.9 months. It is concluded that sodium hypochlorite solution stored in amber-glass bottles should carry a 23-month expiry date on chemical stability.

Drug Stability↗
PubMed1981

Stability and sterility of cimetidine admixtures frozen in minibags.

The stability and sterility of cimetidine hydrochloride admixtures after freezing for extended periods were investigated. Cimetidine hydrochloride, 300 mg, was added to each of six 50-ml minibags containing 5% dextrose injection. The cimetidine concentration was determined and the bags were frozen for up to 30 days. After freezing for the appropriate length of time, the bags were thawed. Cimetidine concentrations were determined by high-pressure liquid chromatography immediately and then daily for eight days while the admixtures were refrigerated. Sterility tests were carried out throughout the study. Data were analyzed by least-squares linear regression to test for trends. The cimetidine hydrochloride admixtures were stable while frozen for up to 30 days and for at least eight days following thawing when kept under refrigeration. Sterility of the admixture was maintained throughout the study period.

Cimetidine↗
PubMedDate not supplied

The effect of time and cholecystectomy on experimental biliary tree dilatation. A multi-imaging evaluation.

The changes of the biliary tree following distal bile duct obstruction and its release were confirmed by biliary scintigraphy and monitored by serial ultrasonography, computed tomography, and values of serum bilirubin and alkaline phosphatase in 14 mongrel dogs. The degree and rate of biliary dilatation were independent of cholecystectomy. The most rapid rate of extrahepatic dilatation occurred within the first 48 hours, while dilated intrahepatic ducts were first recognized three to six days after obstruction. Following release of the obstruction, the degree and rate of resolution of the biliary dilatation were independent of the duration of ligation (one vs. two weeks) and cholecystectomy. The dilatation resolved slowly. Dilated intrahepatic ducts were recognized for as long as eight to 13 days, while extrahepatic biliary dilatation was still present for 13 weeks, at which time the experiment was terminated. It is postulated that the extrahepatic biliary dilatation will approach a plateau approximately one month after total biliary obstruction. It appears that if the obstruction lasts more than one week, it results in irreversible damage to the elasticity of the extrahepatic ducts. Thus, after release of the obstruction, serial biliary imaging is indicated until a new baseline of the biliary tree diameter has been established.

Alkaline Phosphatase↗