The results of using a product of serum thyroxine and triiodothyronine binding coefficient, estimated by simple methods, to give a ;free thyroxine index' in normal women, in pregnant women, and in patients taking oral contraceptives is described. The method is believed to provide a reliable means of assessing thyroid status, and very close agreement, with no significant difference between the mean values obtained for the free thyroxine index, was found in the groups studied. Certain changes, which may be significant, in the values obtained in patients on oral contraceptive treatment of varying duration were noted.

Adolescent↗

PubMed1968

Effect of beta-adrenergic blockade on finger tremor and Achilles reflex time in anxious and thyrotoxic patients.

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Achilles Tendon↗

PubMed1967

Use of Sephadex column chromatography in the assessment of thyroid status.

A method is described for assessing thyroid status using Sephadex column chromatography of serum samples with added (125)I triiodothyronine. The method is simple and inexpensive. It gave a correct diagnostic result in 97% of 258 euthyroid, 90% of 80 hyperthyroid, 78% of 59 hypothyroid, and 67% of 50 euthyroid, ill patients. The principle of the method and its limitations are briefly discussed.

Chromatography↗

PubMed1967

Comparison of three simple methods for the assessment of "free" thyroid hormone.

A dialysis method for estimating ;free' thyroxine is compared with two indirect methods using the uptake of triiodothyronine by the red cells and by a Sephadex column. The three methods give results which correlate well and the Sephadex method is the simplest. The theoretical basis of such tests and their role in the assessment of thyroid status is briefly discussed.

Chromatography↗

PubMed1966