PubMed Health⌕ Search

Biomedical subjects

T M Hudson

Publications and source records attributed to T M Hudson.

At least 19 recordsLinked to original sources
PubMed1990

Magnetic resonance appearance of fibromatosis. A report of 14 cases and review of the literature.

We reviewed retrospectively the magnetic resonance (MR) images of 14 soft-tissue lesions of fibromatosis (desmoid tumors) encountered in 11 patients. The lesions were typically inhomogeneous in texture and round to oval in configuration. Margins were well-defined in 78% of the lesions at presentation and were infiltrating in all recurrences. On T1-weighted spin echo MR images, the predominant signal intensity was either isointense or minimally hyperintense when compared with skeletal muscle. On T2-weighted MR images the predominant signal intensity was typically intermediate between skeletal muscle and subcutaneous fat or isointense to fat. Linear and curvilinear areas of decreased signal intensity were distributed throughout the lesions on both pulse sequences in 86% of cases. This pattern strongly suggested fibromatosis. Speculation concerning possible etiologies of this appearance are discussed, and the relevant literature on previously reported cases is reviewed.

Adolescent↗
PubMed1989

Soft-tissue masses: diagnosis using MR imaging.

The MR images of 112 soft-tissue masses of various causes were retrospectively reviewed. Pathologic diagnosis by biopsy was available in 96 cases. Diagnosis in the remaining 16 cases was established by characteristic radiographs, CT scans, and/or arteriograms, in conjunction with appropriate history and clinical follow-up. All masses were evaluated with both T1-weighted, 300-600/20-30 (TR/TE), and T2-weighted, 2000/80-100, images. They were reviewed to determine (1) if these images were sufficiently unique to allow a preoperative diagnosis based exclusively on the MR appearance and (2) if benignity vs malignancy could be predicted on the basis of the analysis of the MR image characteristics of the lesion. Concerning the latter, attention was directed to the margins of the lesions, to the impact of the lesion on the surrounding tissues (edema, infiltration, etc.), and to the intensity and homogeneity of the MR signal of the lesion. MR images were sufficiently characteristic to allow a specific diagnosis in 27 (24%) of the 112 cases (10 lipomas, eight hemangiomas, six pigmented villonodular synovitis, two hematomas, and one arteriovenous malformation). MR was incapable of reliably distinguishing between benign and malignant soft-tissue tumors.

Abscess↗
PubMed1987

The management of primary lymphoma of bone.

From October 1962 through April 1982, 21 patients with the diagnosis of primary lymphoma of bone (18 monostotic, stages IE and IIE; 3 polyostotic) were treated with curative intent. A combination of chemotherapy and radiation therapy was used in 11 patients, local treatment alone in 9 patients, and chemotherapy alone in one patient. Overall 5-year survival for the patients treated with curative intent was 56%. Standard work-up has changed over the 20-year study period. Five-year survival for the subset of eight stage I and II patients with full pretherapy staging was 83%. Prognosis was significantly correlated with extent of pretherapy staging. Treatment parameters that also seemed to predict outcome were the aggressiveness of chemotherapy and the use of irradiation or surgery for local-regional disease; the only local failure occurred in the patient who received chemotherapy alone. Complications of radiation therapy alone and in combination with chemotherapy are discussed and correlated with irradiation dose. Radiation therapy techniques are described, and a management approach is recommended.

Adolescent↗
PubMed1987

Calcific tendinitis in unusual sites associated with cortical bone erosion.

Five cases of calcific tendinitis with radiographic evidence of cortical bone erosion are presented. All five cases arose at unusual sites: two at the pectoralis major insertion on the proximal humerus, two at the insertion of the gluteus maximus, and one at the insertion of the adductor magnus. Biopsy was performed in four cases and revealed areas of histiocytic infiltration, amorphous spherules of calcification, and areas of giant cell reaction extending into the cortex. To our knowledge, calcific tendinitis presenting with radiographic evidence of bone erosion has not been reported previously.

Adult↗
PubMed1986

Statistical analysis of statural growth following kidney transplantation.

Factors affecting the growth rates of 59 children and adolescents for the first 2 years following kidney transplantation were evaluated. The factors assessed were age at transplantation, renal function, prednisone dosage, donor source, and prior history of transplantation. The observed growth velocity was expressed as the percentage, of the growth velocity predicted by bone age. Normal growth (greater than or equal to 80%) was exhibited by 37% of the patients and 22% had accelerated growth (greater than or equal to 100%). The chronologic age at transplantation did not correlate significantly with growth when bone age was used as the reference for expected velocity. Males grew better than did females. There was a unique sex/race interaction with black males growing most rapidly. Better renal function, the ability to lower prednisone dosage, alternate day prednisone administration, and a decreasing diastolic blood pressure were positively correlated with better growth rates after transplantation. The donor source and prior history of transplantation did not significantly influence growth rate.

Adolescent↗
PubMed1986

Statistical analysis of statural growth following kidney transplantation.

Factors affecting the growth rates of 59 children and adolescents for the first 2 years following kidney transplantation were evaluated. The factors assessed were age at transplantation, renal function, prednisone dosage, donor source, and prior history of transplantation. The observed growth velocity was expressed as the percentage of the growth velocity predicted by bone age. Normal growth (greater than or equal to 80%) was exhibited by 37% of the patients and 22% had accelerated growth (greater than or equal to 100%). The chronological age at transplantation did not correlate significantly with growth when bone age was used as the reference for expected velocity. Males grew better than did females. There was a unique sex/race interaction with black males growing most rapidly. Better renal function, the ability to lower prednisone dosage, alternate day prednisone, and a decreasing diastolic blood pressure were positively correlated with better growth rates after transplantation. Donor source and prior history of transplantation did not significantly influence growth rate.

Adolescent↗
PubMed1986

Computed tomography of extraosseous ganglia.

Computed tomography (CT) was performed in six patients with painful soft-tissue masses where sarcoma was suspected. Incisional or excisional biopsy proved all to be extraosseous ganglia. CT delineated the anatomic relationships of the masses. The CT density of four of the ganglia was 18 Hounsfield Units (HU), consistent with that of fluid-filled lesions. Contrast medium did not enhance the lesions on CT. Angiography was performed in four cases and demonstrated hypovascular masses with no vessel displacement. Plain radiographs and technetium bone scintigrams were nonspecific. CT was the best preoperative confirmation of the diagnosis of benign extraosseous ganglia and the best method of localizing the lesions with respect to surrounding bone and soft tissues.

Adolescent↗
PubMed1985

Scintigraphy of aggressive fibromatosis.

Thirteen patients with aggressive fibromatosis underwent skeletal scintigraphy and computed tomography as part of their preoperative staging. Bone involvement was visible on plain radiographs of three patients. For the other 10 patients, the presence or absence of bone involvement was shown best by computed tomography (CT) in five instances, and best by scintigraphy only once. The two studies were equally useful four times. Although skeletal scintigraphy has previously been found to be very accurate for the evaluation of bone involvement by soft tissue sarcomas, it was less useful in these patients with aggressive fibromatosis.

Adolescent↗
PubMed1985

Limitations of computed tomography following excisional biopsy of soft tissue sarcomas.

Twenty-one patients were evaluated by computed tomography (CT) following complete or incomplete excisional biopsy of soft tissue sarcomas. Since the surgical margins were inadequate, additional treatment was required, and CT was intended to identify and delineate any residual tumor. Thirteen patients had no palpable mass in the operative area. In these, eleven CTs showed no tumor, but microscopic tumor was found in seven. The other two CTs showed masses, but both proved to be hematomas. Eight patients had palpable masses and seven proved to be residual tumor. Of these, two CTs failed to show the residual tumor. Five CTs correctly identified residual tumor, but two of them failed to show the entire tumor extent. Computed tomography did not correctly predict the presence or absence of microscopic residual tumor when there was no palpable mass, and was at least partly inaccurate in delineating residual tumor in four of eight patients with palpable masses.

Adolescent↗
PubMed1985

Magnetic resonance imaging of bone and soft tissue tumors: early experience in 31 patients compared with computed tomography.

In 31 patients with 21 soft tissue and 10 bone tumors, magnetic resonance imaging (MRI) and computed tomography (CT) were equally effective in delineating the margins of most soft tissue tumors, and the margins of bone tumors from fat and adjacent normal bone. However, MRI was superior to CT in delineating bone tumors from adjacent muscle, and in showing the relationships to bone of the deep margins of some soft tissue tumors. This was true because the quality of CT images around thick cortical bone often was severely degraded by streak artifact, which does not occur in MRI. Excellent anatomic detail was achieved on MRI by spin echo pulse sequences with short repetition times. Bone tumors were delineated best by spin echo 1000/30 images, and soft tissue tumors by spin echo 1000/30 or inversion recovery images.

Bone Neoplasms↗
PubMed1985

Magnetic resonance imaging of fluid levels in an aneurysmal bone cyst and in anticoagulated human blood.

Magnetic resonance imaging (MRI) demonstrated a fluid level within an aneurysmal bone cyst (ABC). Since the ABC contained gross blood at operation, an anticoagulated human blood sample was studied by MRI also, and a fluid level was again clearly visible. MRI pulse sequences emphasizing T1 contrast showed the fluid levels most clearly in both the ABC and the blood. Sequences emphasizing T2 contrast showed homogeneous, bright signals in the ABC and in the blood, with no visible fluid level in the ABC and a nearly invisible one in the blood. In the blood sample, the calculated plasma T1 value was 1585 ms, and that of the red cells was 794 ms.

Adolescent↗
PubMed1985

Computed tomography of parosteal osteosarcoma.

Twelve patients with parosteal osteosarcomas were evaluated by computed tomography (CT). CT accurately defined the extent of the tumors for purposes of surgical planning, although tumor bone often could not be distinguished from thickened host bone. Nine tumors invaded the medullary cavity, a feature that implies a poorer prognosis when the tumor also contains high-grade areas. Six CT studies accurately detected the medullary invasion, but three did not. Lucent areas within dense tumors contained either benign tissue or high- or low-grade tumor; CT did not differentiate among these different tissues. CT also did not reveal small satellite nodules of tumor beyond the main tumor mass.

Adolescent↗
PubMed1984

Radiology of giant cell tumors of bone: computed tomography, arthro-tomography, and scintigraphy.

Radiologic studies of 50 giant cell tumors of bone in 48 patients were useful in assessing the anatomic extent for planning surgical treatment. Contrast-enhanced computed tomography (CT) provided the most useful and complete evaluation, including soft tissue extent and relationship to major vessels. Angiography was useful when the extraosseous extent and vascular relationships were not entirely clear on CT. Arthro-tomography was the best way to evaluate tumor invasion through subchondral cortex and articular cartilage. Reactive soft tissues, with edema and hyperemia, were difficult to distinguish from tumor tissue on CT and angiograms. Bone scintigrams often showed intense uptake beyond the true tumor limits.

Adolescent↗
PubMed1984

Joint fluoroscopy before arthrography: detection and evaluation of loose bodies.

Fluoroscopy before injection of contrast medium increased the usefulness and accuracy of arthrography in 14 of 22 patients with possible intra-articular loose bodies. Although loose bodies wedged between articular surfaces deep within the joint were immobile, a typical tumbling motion on fluoroscopy reliably identified most free-floating loose bodies. Fluoroscopy sometimes revealed abnormalities more clearly than the plain radiographs or arthrograms.

Ankle Joint↗
PubMed1984

Digital vascular imaging in children. A preliminary report.

Whereas digital subtraction angiography (DSA) has been extensively used in adults, few reports have dealt with its application in children. We utilized DSA in 52 children, studying various vascular territories. Technically satisfactory studies were obtained in 89%. Motion artifacts is the foremost technical problem. Extremity DSA with arterial injection was highly successful in a number of cases. Thoracic vascular studies were also successful, as were studies of the head and neck, whereas renal and abdominal vessel studies were somewhat less successful. DSA with arterial injection may be expected to replace conventional angiographic studies in selected cases and appears to be an excellent screening method also in children.

Adolescent↗
PubMed1984

Perivascular soft tissue spread of osteosarcoma.

Skeletal scintigraphy of a distal femoral osteosarcoma revealed a band of soft-tissue uptake in the medial thigh extending to the groin, which corresponded to direct perivascular tumor extension.

Adult↗