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Biomedical subjects

T M Hudson

Publications and source records attributed to T M Hudson.

50 records · Page 3Linked to original sources
PubMed1981

Radionuclide imaging of soft tissue neoplasms.

Two classes of radiopharmaceuticals may be used for imaging tumors of the musculoskeletal system. The first is comprised of soft tissue or tumor specific agents such as gallium-67, bleomycin, and radionuclide-labeled antibodies, which may be useful for detecting and localizing these tumors. The other class of tracer is comprised of those with avidity for bone. The 99mTc-labeled-phosphate skeletal imaging compounds have been found to localize in a variety of soft tissue lesions, including benign and malignant tumors. In 1972, Enneking began to include bone scans in the preoperative evaluation of soft tissue masses. Later, he and his associates reported that these scans were useful in planning operative treatment of sarcomas by detecting involvement of bone by the tumors. Nearly all malignant soft tissue tumors take up bone-seeking radiopharmaceuticals, and bone involvement was indicated in two-thirds of the scans we reviewed. About half of benign soft tissue lesions had normal scans, but the other half showed uptake within the lesion and a few also showed bone involvement. Careful, thorough imaging technique is essential to proper evaluation. Multiple, high-resolution static gamma camera images in different projections are necessary to adequately demonstrate the presence or absence of soft tissue abnormality and to define the precise relationship of the tumor to the adjacent bone.

Bleomycin↗
PubMed1981

The value of angiography in planning surgical treatment of bone tumors.

Evaluation of 314 angiograms revealed that they were often very useful in planning nonablative resection of bone tumors because they demonstrated the relationships of the tumors to major vessels. Increasing experience indicates that computed tomography can accurately define intraosseuous and soft-tissue extent of bone tumors. If vascular relationships are not precisely shown by computed tomography, angiography may still be required. The angiograms occasionally also helped in anticipating operative blood loss, demonstrating variants of vascular anatomy, or planning biopsy. Meticulous angiographic technique and close communication between surgeon and angiographer are essential.

Bone Marrow Diseases↗
PubMed1981

Radiological evaluation of chondroblastoma.

Eleven new and six recurrent chondroblastomas were studied with multiple radiological imaging methods (plain radiography, conventional tomography, computed tomography, radionuclide bone scanning, and angiography). When the plain radiographic appearance was typical, conventional tomography or computed tomography (CT) was helpful, but other studies were not. Periosteal reaction and angiographic hypervascularity were common and did not indicate cortical breakthrough. For large, aggressive, or atypical lesions, conventional tomography and CT were helpful in delineating anatomic extent, and angiography was of value in demonstrating major vessel displacement. Radionuclide bone scanning was not useful.

Angiography↗
PubMed1981

Elbow arthrography.

Arthrography of the elbow is performed infrequently, but may be quite useful in demonstrating the presence, number, and location of intra-articular loose bodies, and in evaluating articular cartilaginous surfaces. Such information may be valuable in the selection of an operative versus a nonoperative course of treatment, and, if surgery is elected, it may be useful to the surgeon in planning the operative approach and in locating the position of all of the abnormalities present. Elbow arthrography is also of occasional value in demonstrating synovial disease, evaluating certain traumatic disorders, and verifying needle position during aspiration. A useful and accurate elbow arthrogram requires careful planning and may require considerable time to perform completely. Plain radiographs should be carefully examined. Fluoroscopic observation before injection may be extremely helpful, and thoughtful selection of the type and amount of contrast medium is necessary. Adequate arthrographic films may be obtained only after careful consideration of the abnormalities to be demonstrated and their location in the joint. Tomography is almost always necessary for a thorough evaluation.

Cartilage, Articular↗
PubMed1981

The role of radionuclide bone-scanning in determining the resectability of soft-tissue sarcomas.

In sixty patients with soft-tissue sarcoma, radionuclide bone scans were 92 per cent accurate in evaluating the presence or absence of involvement of contiguous bone by the tumor itself, by the tumor's reactive pseudocapsule, or by tissue contaminated during inadequate excision. The scans were most helpful when the relationship of the tumor to the bone was crucial in determining the resectability of the tumor. Meticulous imaging technique is essential to a complete and accurate radionuclide study. High-resolution, high-count gamma-camera scans in multiple projections are required for precise localization of tumor.

Biopsy↗
PubMed1980

Radionuclide imaging of lipoma and liposarcoma.

Radionuclide imaging with technetium-99m phosphate compounds was performed in 18 patients with deep-seated soft-tissue masses. The histologically established diagnosis was intra- or intermuscular lipoma in 13 patients and liposarcoma in five. Radionuclide scans demonstrated disparate scintigraphic characteristics in these two often clinically similar lesions. Soft-tissue radionuclide accumulation occurred in two lipomas and corresponded to radiographically evident calcification. All liposarcomas were uncalcified and demonstrated intense radionuclide activity. This activity may be related to the angiographic and histologic hypervascularity of liposarcomas, which is also demonstrable on computed tomography as contrast enhancement; hence, these modalities offer the same nonspecific diagnostic information. It is concluded, however, that plain radiography and radionuclide scaning should suffice to establish the diagnosis of lipoma.

Adult↗
PubMed1980

Radiology of infiltrating angiolipoma.

Infiltrating angiolipomas are rare benign soft-tissue neoplasms that are locally aggressive and require wide surgical excision. Of 10 patients studied, five showed serpiginous densities intermixed with fat on plain films. Six radionuclide bone scans showed uptake by the soft-tissue lesion. Eight angiograms demonstrated poorly marginated, very hypervascular lesions. Computed tomography (CT) in five patients yielded excellent visualization of predominantly low density lesions that invaded and replaced skeletal muscle. The combination of angiography and CT indicated the specific diagnosis and demonstrated the size, extent, and vascularity of the tumors.

Adult↗
PubMed1979

Angiography of malignant fibrous histiocytoma of bone.

Angiograms of 10 cases of malignant fibrous histiocytoma of bone were reviewed and correlated with surgical and pathological findings. Nine tumors were hypervascular. Seven demonstrated malignant characteristics (laking in one and coarse tumor vessels in 6). Seven tumors displaced adjacent normal vessels. All angiograms accurately delineated soft-tissue masses and cortical breakthrough but intraosseous extent was less clearly defined. Tumor thrombi within draining veins were evident retrospectively in one instance. Angiography in these cases contributed substantially to surgical management.

Angiography↗
PubMed1977

Improved musculoskeletal angiography with large volume contrast injection and priscoline.

Previously published studies of musculoskeletal angiography have not discussed the technical details of how the angiograms were performed. In the present report, two series of 57 consecutive angiograms were compared with respect to radiologic quality and clinical usefulness. The second series differed from the first in closer consultation between angiographer and orthopaedist and the use of intra-arterial Priscoline, large volume contrast injection, multiple views, geometric magnification, and photographic subtraction. These efforts were rewarded by greater vascular detail and better delineation of tumors on the angiograms. Especially with respect to soft tissue lesions, the surgeon found the studies more accurate and more useful in planning surgical management.

Angiography↗
PubMed1976

Isolated rotatory subluxation of the carpal navicular.

Rotatory subluxation of the carpal navicular can cause wrist pain and may lead to severe and disabling degenerative changes. Correct diagnosis depends on recognition of the typical roentgenographic signs. Sixteen patients with neither rheumatoid arthritis nor a lunate or a perilunate dislocation had rotatory subluxation in nineteen wrists. Many had only vague or remote histories of trauma. There were a navicular-lunate gap in all nineteen wrists, and foreshortening of the navicular in sixteen wrists, usually with a ring sign. The abnormalities were best demonstrated on well-centered posteroanterior roentgenograms of the wrist with the hand in slight radial deviation. In two patients, wrist arthrography demonstrated abnormal communication between radiocarpal and intercarpal joints.

Aged↗
PubMed1975

Angiography in the management of musculoskeletal tumors.

The contribution to pretreatment evaluation and surgical planning of 200 angiograms of bone and soft tissue lesions, mostly tumors, was evaluated. Their accuracy was studied by careful post-operative examination of gross surgical specimens and histologic sections. The angiograms were helpful in delineating the anatomic extent of lesions and, therefore, in planning the appropriate resection or amputation. This was particularly true in lesions treatable by radical local resection, such as most malignant tumors of soft tissues, giant cell tumors of bone, parosteal osteosarcomas, chondrosarcomas and occasional small central osteosarcomas. The angiograms were of some help in confirming or detecting residual or recurrent tumor and prior resection. This was not true immediately after inadequate local resections because residual tumor was likely to be quite small and reactive vascularity secondary to operation was confusing. Angiography was not accurate or helpful in distinguishing benign from malignant lesions when the clinical presentation and roentgenographic findings were confusing. The surgeon relied on biopsy rather than angiography. Aso, although we saw lymph node blushes on several angiograms, we could not reliably interpret whether or not this represented tumor metastasis. The vascularity of pathologic fractures was also confusing. Pelvic angiograms were difficult to interpret because of the complex anatomy. We made most of our serious mistakes in delineating tumor extent in pelvic lesions. Angiography is valuable in planning operative treatment of tumors if radical local resection is considered or if physical examination and roentgenographic findings do not indicate the appropriate level of amputation.

Angiography↗
PubMedDate not supplied

Cystic intramuscular myxoma. Report of a case.

CT and ultrasound examination of a soft tissue mass in a 43-year-old woman revealed a large, cystic lesion. At surgery, a myxoma was found deep to a large cyst. Although myxomas have been reported frequently to contain one to 5 mm cysts, none has previously been reported associated with a large cyst that concealed the solid tumor. Large intramuscular cysts are rare; a cystic appearance on CT or ultrasound examination of an intramuscular mass should suggest a possible underlying solid lesion.

Adult↗