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T M Milen'kaia

Publications and source records attributed to T M Milen'kaia.

14 recordsLinked to original sources
PubMed2002

[Associative analysis of the connection between mutation C1167T in the catalase gene and polymorphic marker D6S392 nearby the Mn-dependent superoxide dismutase gene with diabetic microangiopathies].

AIM: To study allele polymorphism of two variable regions [C1167T substitution in the catalase (CAT) gene D6S392 microsatellite near the Mn-dependent superoxide dismutase (SOD2) gene] was studied in insulin-dependent diabetic (IDDM) patients with (n = 36) or without (n = 56) diabetic nephropathy, and with (n = 30) or without (n = 44) diabetic retinopathy. MATERIAL AND METHODS: Both polymorphic regions were amplified using polymerase chain reaction (PCR). PCR products were separated using polyacrylamide (D6S366) or agarose (C1167T) gel electrophoresis. In a case of C1167, PCR-amplified products were digested with BstXI restriction endonuclease before electrophoresis. A significance of the difference between allele distributions in complicated and uncomplicated IDDM patients was estimated using the exact Fisher's test. RESULTS: No significant difference was observed in allele and genotype frequencies in complicated and uncomplicated IDDM subjects. CONCLUSION: C1167 polymorphism in the CAT gene and D6S366 near the SOD2 gene are not associated with the development of diabetic nephropathy and diabetic retinopathy in IDDM.

Adolescent↗
PubMed1999

[Polymorphism of gene encoding vascular angiotensin II receptor and microangiopathies in patients with insulin-dependent diabetes mellitus].

Polymorphism A1166C of the AT1R gene encoding angiotensin vascular receptor [replacement of C (cytosine) for A (adenine)) at position 1166] was compared in patients with insulin-dependent diabetes mellitus (IDDM) complicated by diabetic nephropathy (DN) and in noncomplicated patients (n = 27 and n = 41, respectively) and also in patients with IDDM complicated by diabetic retinopathy (DR) and in correspondent noncomplicated individuals (n = 30 and n = 44, respectively). The frequency of AT1R gene alleles and genotypes in patients with IDDM complicated by DN did not differ significantly from that observed in patients with noncomplicated IDDM. In contrast, in patients with IDDM complicated by retinopathy, a significant decrease in the content of A allele (68.3% against 82.6%) and a significant increase in the content of C allele (31.7% against 17.4%) was found as compared with the control group. Thus, in the Moscow population, A1166C polymorphism of the AT1R gene is not associated with diabetic renal complications but indeed associated with diabetic retinal complications. C allele is a risk factor of DR (the relative risk, RR, is equal to 2.17), and A allele is, in contrast, a protective factor against early retinopathy development (RR is equal to 0.49).

Adolescent↗
PubMed1998

[Polymorphism of the angiotensin I-converting enzyme gene in diabetic retinopathy patients and type 2 diabetes mellitus patients with myocardial infarction].

The insertion/deletion polymorphism (I/D) of the angiotensin I-converting enzyme gene (ACE) was examined in type I diabetes mellitus patients (DM) with (n = 31), or without (n = 33) retinopathy, and in type 2 DM patients with either myocardial infarction (MI; n = 75), or with (n = 37), or without (n = 178) retinopathy. No association between the ACE gene and retinopathy in type 1 and type 2 DM patients was revealed. In the type 2 DM patients with MI, a statistically significant (P < 0.05) elevation of the D allele frequency (64%) compared to that without MI (55.3%), together with statistically nonsignificant prevalence of the DD homozygotes (41% versus 30.6%) was observed. Our data indicate that the D allele (RR 1.43) and DD genotype (RR 1.75) are risk factors for myocardial infarction in the type 2 DM patients.

Adult↗
PubMed1996

[The thromboxane-synthesis inhibitor Ibustrin in the treatment of diabetic angiopathies].

16 patients with insulin-dependent diabetes mellitus (IDDM) lasting 8-19 years had pronounced diabetic nephropathy (proteinuria stage), retinopathy (stage I, II or III), disturbed circulation in the lower limbs detected at foot dopplerography. For 3 months these patients received ibustrin (inhibitor of cyclooxigenase, blocker of tromboxane A2 synthesis and platelet aggregation) before renal function underwent positive changes: glomerular filtration rate increased in 13 patients (81%), 24-h proteinuria decreased in 12 patients (75%). Retinal vascular condition improved in 5 of 6 patients with nonproliferative retinopathy and in 2 of 5 patients with preproliferative retinopathy, in 1 and 3 patients stabilization occurred, respectively. In proliferative retinopathy improvement and stabilization were registered in 1 and 3 of 5 patients, respectively. According to feet artery dopplerography the improvement, no changes and moderate aggravation occurred in 10(62%), 3(19%) and 3(19%) of patients, respectively The conclusion is made that ibustrin effectively inhibits progression of IDDM vascular complications, especially at early angiopathy stages.

Adolescent↗
PubMed1990

[The efficacy of vitrectomy in severe complicated proliferating diabetic retinopathy].

Vitrectomy was made in 69 patients (71 eyes) with proliferative retinopathy complicated by hemorrhage into the vitreous body. In most cases (90.1%), visual acuity didn't exceed 0.05. To prevent possible complications at the time of operation and in the postoperative period preliminary cryocoagulation before vitrectomy was made in a part of the patients (47 patients, 49 eyes). Comparative analysis of results after vitrectomy with and without cryocoagulation has shown that the incidence of operative complications was remarkably lower, than in the first group of patients. Hemorrhage into the vitreous body was observed in combined intervention in 4.0%, and in vitrectomy without preliminary intervention--in 22.7% of cases. Restoration of transparency of the vitreous body was recorded to be more frequent in group I (48.9% against 35.2%). In remote terms, visual acuity improved in 85.7% in group I, and in 45.5%--in group II. Vitrectomy with preliminary cryocoagulation is indicated to all patients with complicated far-advanced proliferative diabetic retinopathy.

Adult↗
PubMedDate not supplied

[The laser correction of recurrent elevated intraocular pressure after a surgical operation to control glaucoma complicated by the blocking of the postoperative fistula by the root of the iris].

Laser intervention was carried out in 18 patients (18 eyes) with open-angle glaucoma and decompensated intraocular pressure, that developed in 2 weeks--5 years after primary antiglaucoma surgery. Developed glaucoma stage was diagnosed in 16 eyes, in 2 eyes far-advanced condition was found. Blocking of the fistula by the iridal root was responsible for the inefficacy of fistulizing surgery. Laser trabeculoplasty to compensate for the intraocular pressure was carried out in 18 eyes, in 9 eyes this treatment was combined with gonioplasty. Stable normalization of intraocular pressure was observed in 13 eyes in remote periods after laser coagulation. Analysis of the results has brought the authors to a conclusion that the administered laser trabeculoplasty as an individual treatment modality and in combination with gonioplasty is fairly effective, results in prolonged compensation of the ophthalmic tone, and is altogether less traumatic than repeated surgery.

Aged↗