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Biomedical subjects

T M Mukherjee

Publications and source records attributed to T M Mukherjee.

44 records · Page 3Linked to original sources
PubMed1971

Electron microscopic localization of alpha toxin within the staphylococcal cell by ferritin-labeled antibody.

Highly purified staphylococcal alpha toxin has been used to produce monospecific anti-alpha antibody in rabbits. Gamma globulin prepared from the serum of these rabbits was coupled with ferritin by using toluene diisocyanate. Staphylococcal cells which had been disrupted by two passages through an LKB X-press were treated with this conjugate. Electron microscopic examination of this material showed alpha toxin or an antigenically mature precursor located on the cytoplasmic membrane. The possible function of alpha toxin in this situation is discussed.

Antibodies, Bacterial↗
PubMed1967

A comparative study of the ultrastructure of microvilli in the epithelium of small and large intestine of mice.

A comparative analysis of the fine structure of the microvilli on jejunal and colonic epithelial cells of the mouse intestine has been made. The microvilli in these two locations demonstrate a remarkably similar fine structure with respect to the thickness of the plasma membrane, the extent of the filament-free zone, and the characteristics of the microfilaments situated within the microvillous core. Some of the core microfilaments appear to continue across the plasma membrane limiting the tip of the microvillus. The main difference between the microvilli of small intestine and colon is in the extent and organization of the surface coat. In the small intestine, in addition to the commonly observed thin surface "fuzz," occasional areas of the jejunal villus show a more conspicuous surface coat covering the tips of the microvilli. Evidence has been put forward which indicates that the surface coat is an integral part of the epithelial cells. In contrast to the jejunal epithelium, the colonic epithelium is endowed with a thicker surface coat. Variations in the organization of the surface coat at different levels of the colonic crypts have also been noted. The functional significance of these variations in the surface coat is discussed.

Animals↗
PubMedDate not supplied

Exocytosis of neurosecretory granules in small cell undifferentiated carcinoma.

The tumor cells in the pleural effusions of a case of small cell undifferentiated carcinoma have been studied by light microscopy and by thin section and freeze-fracture electron microscopy. Evidence of exocytosis of neurosecretory granules from the tumor cells is presented. The tumor cells form clumps, with the cells joined by focal tight junctions and small desmosomes. These findings are discussed with reference to the neuroendocrine origin of these tumors and the role of the junctional complexes in the formation of tumor cell aggregates.

Aged↗