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Biomedical subjects

T M Patel

Publications and source records attributed to T M Patel.

10 recordsLinked to original sources
PubMed1995

Difficult mitral valvuloplasty: an "over the wire" modification of Inoue technique.

Failure to cross the mitral valve remains an important cause of the technical failure in performing mitral valvuloplasty with the Inoue technique, especially during initial experience of the operator. We report two such cases where conventional methods failed and an "over the wire" modification of the Inoue technique had to be utilized. This particular modification can be beneficial in the rare cases where negotiating the Inoue balloon across the mitral valve is particularly difficult.

Adult↗
PubMed1992

Left ventricular mass and function in children with severe protein energy malnutrition.

We studied 25 children, aged 1-5 years (mean 2.65 +/- 0.8 years) with severe protein energy malnutrition, and compared their left ventricular mass and function to those of 26 healthy, age- and sex-matched normal children. The mean left ventricular mass in the patients was lower than that in the controls (25.75 +/- 8.09 g vs. 32.44 +/- 11.64 g; P less than 0.05, C.I. 2.08 to 11.30). However, left ventricular mass (g)/kg body weight was significantly increased in the patients (4.44 +/- 1.45 vs. 2.42 +/- 0.87; P less than 0.001, C.I. 1.28 to 2.76) suggesting relative cardiac "sparing". The systolic function indices like ejection fraction, percentage fractional shortening, and velocity of circumferential fiber shortening were not significantly different in the patients and in the normal children. The left ventricular end-diastolic volume, stroke volume and cardiac output were reduced in proportion to decrease in body size in the patients, so that the cardiac index was not reduced but slightly increased in the patients. (5.95 +/- 1.9 l/min/m2 in patients, 4.97 +/- 1.4 l/min/m2 in controls; P less than 0.05, C.I. 0.04 to 1.92). There was no significant difference in any of these parameters of left ventricular function or mass in patients with marasmus, as compared to those of patients with marasmic kwashiorkor. Amongst the 25 patients, however, 5 patients (20%) had an ejection fraction of less than 50%. Compared to the other 20 patients, these 5 patients had lower left ventricular mass (18.4 +/- 4.3 g vs. 27.5 +/- 7.8 g, P less than 0.05 C.I. 1.63 to 16.75), lower left ventricular mass (g)/kg body weight and a worse prognosis.(ABSTRACT TRUNCATED AT 250 WORDS)

Child, Preschool↗
PubMedDate not supplied

Noninvasive assessment of left ventricular function in asymptomatic diabetics and its relation to metabolic control and microangiopathy.

Fifty otherwise healthy patients with diabetes mellitus (37 males, 13 females; mean age: 53 +/- 10 years) of more than five year duration were compared with twenty six healthy age and sex matched controls. Detailed echocardiographic evaluation was done in all and systolic time intervals (STI) were measured. In diabetics, metabolic control and presence of microangiopathy were evaluated. PEP Index (patients: 146.23 +/- 17.04; controls: 121.99 +/- 5.15; p less than 0.001), PEP/LVET ratio (patients: 0.38 +/- 0.07; controls: 0.32 +/- 0.02; p less than 0.001), LVEF% (patients: 54.1 +/- 10.56; controls: 64.71 +/- 6.33; p less than 0.001), all were significantly altered in diabetics suggesting left ventricular dysfunction. The left ventricular posterior wall thickness (patients: 0.96 +/- 0.23 cm; controls: 0.85 +/- 0.12 cm; p less than 0.01) and interventricular septal thickness (patients: 1.2 +/- 0.24 cm; controls: 0.87 +/- 0.25 cm; p less than 0.001) in diastole were increased in diabetics. The PEPI correlated with day-to-day control but not with chronic glycemic control of diabetes mellitus. The PEP/LVET was significantly increased in patients with severe, as compared to those with none or mild microangiopathy (p less than 0.05). Thus, significant left ventricular dysfunction is evident in asymptomatic, otherwise healthy diabetics. Both metabolic control and microangiopathy may be responsible for the abnormalities.

Diabetes Mellitus, Type 2↗