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Biomedical subjects

T M Savege

Publications and source records attributed to T M Savege.

At least 37 records · Page 2Linked to original sources
PubMed1975

Intravenous anaesthesia by infusion. A technique using alphaxolone/alphadolone (althesin).

Two hundred and seventy-three patients were anaesthetised using aphaxolone/alphadolone as a sole anaesthetic agent, administered in either a 10% solution or in increments of neat drug. Analgesics were given where necessary. This technique was instituted to provide a method of anaesthesia that avoided pollution of the atmosphere, with its possible harmful effects. As experience was gained, better results were obtained. Overall, 86% of the anaesthetics administered were without problems, 12% presented some difficulty, usually minor movement of the patient, and in 2% this technique was abandoned.

Adult↗
PubMed1974

Controlled sedation with alphaxalone-alphadolone.

Alphaxalone-alphadolone (Althesin), diluted and administered as a controlled infusion, was used as a sedative for 30 patients in an intensive therapy unit. This technique allowed rapid and accurate control of the level of sedation. It had three particularly useful applications: it provided "light sleep," allowed rapid variation in the level of sedation, and enabled repeated assessment of the central nervous system.Sedation was satisfactory for 86% of the total time, and no serious complications were attributed to the use of the drug. Furthermore, though alphaxalone-alphadolone was given for periods up to 20 days there was no evidence of tachyphylaxis or delay in recovery time.

Adult↗