Biomedical subjects

T M Vasankari

Publications and source records attributed to T M Vasankari.

3 recordsLinked to original sources

PubMed1998

Reduced oxidized LDL levels after a 10-month exercise program.

PURPOSE: We studied the effect of a 10-month exercise program on LDL oxidation and other lipid risk factors in 34 sedentary men and 70 women. We hypothesized that decreasing LDL oxidation by raising exercise activity would decrease the risk of atherosclerosis. METHODS: The men and women subjects had a mean (range) age of 43.6 (34-52) and 44.6 (31-58) yr, a body mass of 94.4 (78-144) and 77.6 (56-117) kg, a body mass index of 29.6 (24-44) and 28.6 (21-41), a body fat percentage of 20.4 (13-29) and 31.4 (16-39), and a maximal oxygen uptake of 33.3 (15-50) and 30.4 (18-49) mL.kg-1.min-1, respectively. We measured the baseline levels of conjugated dienes extracted from LDL (LDL-BDC) to assess the amount of circulating LDL oxidation products. The antioxidant potential of LDL samples was estimated in vitro by their potency to resist 2,2'-azobis(2-amidinopropane)HCl-induced peroxidation. The exercise program was tailored individually based on indirect measurement of VO2max at baseline. RESULTS: The mean time of exercise was 257 min.wk-1 for men and 209 min.wk-1 for women. Estimated VO2max increased by 19% during the exercise program in both men and women (both P < 0.0001). Concurrently, the concentration of HDL cholesterol increased by 15% in men (P = 0.0004) and 5% in women (P = 0.043) and that of LDL cholesterol decreased by 10% (P = 0.026) and 11% (P < 0.0001), respectively, whereas serum total cholesterol and triglyceride concentrations remained unchanged. The concentrations of LDL-BDC decreased by 23% (P = 0.0010) and 26% (P < 0.0001) and the ratio of LDL-BDC to LDL by 14% (P = 0.016) and 18% (P < 0.0001) in men and women. The ratio of LDL antioxidant potential to LDL rose by 16% (P = 0.011) and 11% (P = 0.0016), respectively. The mean weight loss during the exercise program was 2.9 kg in men and 1.8 kg in women (both P < 0.0001), whereas body fat percentage fell by 2.3% and 3.2%, respectively. CONCLUSIONS: In addition to increasing HDL cholesterol and decreasing LDL cholesterol, the exercise program is concluded to have improved the quality of the circulating LDL (less oxidized LDL), which may reduce the risk of atherosclerosis.

Adipose Tissue↗

PubMed1997

Effects of acute prolonged exercise on-serum and LDL oxidation and antioxidant defences.

We investigated the acute effects of long-distance running on oxidation of lipids and antioxidant functions in LDL and serum. Eight trained male runners who participated in a 31-km run and 22 male keep-fit runners who participated in a marathon run were enrolled into the study. Venous blood samples were taken before and immediately after the exercise. There were no changes in LDL diene conjugation (LDL-DC) or LDL antioxidant potential (LDL-TRAP) during the exercises. Serum (S-) TRAP and S-alpha-tocopherol rose during the 31-km run (by 22%, p = .0005, and by 29%, p = .011, respectively), and during the marathon (by 16%, p = .0014, and by 7%, p = .031, respectively). S-DC rose during the 31-km run (by 9%, p = .0026), but not during the marathon (p = .14). Preexercise and postexercise S-alpha-tocopherol correlated positively with pre and postexercise S-TRAP in the marathon run (r = .473, 95% CI 0.064 to 0.746, and r = .524, 95% CI 0.131 to 0.774, respectively). Thus, the paradoxical exercise-associated increase in S-TRAP is, at least in part, explained by a simultaneous rise in S-alpha-tocopherol concentration. However, acute exercise does not change LDL-DC or LDL-TRAP concentrations.

Adult↗

PubMed1997

Increased serum and low-density-lipoprotein antioxidant potential after antioxidant supplementation in endurance athletes.

We studied the effect of antioxidant supplementation on acute exercise-induced lipid peroxidation and antioxidant potential measured in serum and low-density-lipoprotein (LDL) samples. Eight endurance athletes repeated a 31-km running exercise twice with an interval of 4 wk. During the 4 wk before the runs, the subjects took in a single-blind randomized order either a combination of antioxidant supplements (the antioxidant trial; 294 mg vitamin E, 1000 mg vitamin C, and 60 mg ubiquinone daily) or placebo (the placebo trial). Venous blood samples were taken before and immediately after the 31-km run in both trials. Antioxidant supplementation raised the LDL antioxidant potential (TRAP) (40% and 30%, P = 0.0031), serum TRAP (9% and 10%, P = 0.0037), and serum alpha-tocopherol concentration (by 59% and 66%, P = 0.0004) in both pre- and postexercise samples, respectively. The supplementation did not, however, affect the concentration of LDL diene conjugation (DC) or of serum DC. Physical exercise increased serum DC (by 18% and 10%, P = 0.0004) but not LDL-DC, and the quantity of the increment of serum DC was not affected by antioxidant intervention. The major cause for the increased LDL-TRAP and serum TRAP after antioxidant supplementation is apparently the elevation of the serum alpha-tocopherol concentration.

Adult↗