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Biomedical subjects

T Mańkowski

Publications and source records attributed to T Mańkowski.

At least 19 recordsLinked to original sources
PubMed1990

[The effect of fenoterol (partusisten) on cAMP and cGMP concentrations, acetylcholine esterase and choline acetyltransferase activities in rat placenta].

Several observations indicate a possible role of the placental cholinergic system in the modulation and maintenance of placental function and subsequently fetal growth and development. We have investigated the effect of Partusisten (1 mg/kg p.o., twice daily, since the 15th to the 20th day of gestation) on cAMP and cGMP concentrations, acetylcholine esterase and choline acetyltransferase activities in rat placenta. The obtained results show that Partusisten increased cAMP concentration and decreased cGMP concentration (see Tab. 1; Fig. 1, 2). Choline acetyltransferase activity was elevated (Tab. 2; Fig. 3) whereas Partusisten had no effect on acetylcholine esterase activity (see Tab. 2; Fig. 4). The results indicate disorders in placental cholinergic system after chronic Partusisten administration to pregnant rats. On the other hand, the marked increase in choline acetyltransferase activity suggested the high adaptability of placenta.

Acetylcholinesterase↗
PubMed1984

[45Ca2+ uptake by rat thymocytes in the presence of blood serum of patients with cystic fibrosis].

The results of examination of 45Ca2+ (uptake by freshly prepared) thymocytes from rat in the presence of blood serum from CF patients and healthy persons as differentiating agent are presented. The presence of the factor responsible for enhanced Ca uptake in the blood serum of CF patients was found in our experimental system. That factor was absent in the blood serum of rats chronically treated with reserpine. This is in agreement with previous findings that this factor was related to the basic genetic defect in CF(6). Very efficient influx of 45Ca2+ into the rat thymocytes (up to 6,2%) being accompanied by increased calcium uptake in the presence of serum factor of CF patients in comparison with control serum of healthy persons should be underlined.

Animals↗
PubMed1983

[Effect of drugs on cyclic AMP levels in the tissues of animals at different stages of ontogenesis. I. Experimental studies on the effect of adrenomimetic drugs on cyclic AMP concentration in the brain of 7-day-old and adult rats].

The purpose of the investigations was the comparison of the adrenergic receptors excitability in brain of 7-days-old and adult rats after adrenaline and isoprenaline administration. The excitation was evaluated biochemically by measurement of the beta receptor-mediated increase in brain cAMP concentration. There was no significant difference in brain tissue cAMP concentration of 7-days-old and adult rats in physiological conditions. The concentration of cAMP in brain of adult rats was not affected after administration both adrenaline and isoprenaline. On the contrary, the concentration of cAMP in brain of 7-days-old rats was significantly increased after each of two examined drugs, indicating that blood-brain barrier is permeable for catecholamines at this age.

Aging↗
PubMed1982

[Radioimmunological monitoring of the treatment of malignant neoplasms in childhood].

In 56 cases of children with tumours, the level of alpha-fetoprotein (AFP) was established with radio-immunological method. There were 15 children with neuroblastoma, 13 with ovarian tumours, 14 with sacro-coccygeal tumours, 7 with tumours of liver and 7 with tumours of testis. The level of AFP was elevated in all children with hepatoblastoma, carcinoma embryonale, and malignant teratoma. Monitoring was performed in 15 children with tumours mentioned above. Usefulness of evaluation of AFP level in blood serum in these tumours has been confirmed by diagnosis. In effective treatment of these tumours, AFP level has fallen down to normal. Its rising up again prognosed tumour's relapse several months before.

Bone Neoplasms↗
PubMed1976

C55-Dolichol: occurrence in pig liver and preparation by hydrogenation of plant undecaprenol.

Apart from the long-chain dolichols (C80-C110), pig liver contains also a family of much shorter polyprenols with dominating C55-polyprenol. This compound was identified as cis/trans-dihydroundecaprenol in which the OH-terminal isoprene residue was saturated. The number of internal trans isoprene residues in this compound was three in comparison with two such residues in long-chain C95-dolichol. Chemical preparation of dihydroundecaprenol with a selectively saturated OH-terminal isoprene residue from fully unsaturated plant undecaprenol is presented.

Animals↗
PubMedDate not supplied

[Atypical form of phenylketonuria caused by lack of dihydrobiopterin synthetase activity].

A case of non-typical phenylketonuria produced by the inactivity of dihydrobiopterin synthetases is presented. Dihydrobiopterin synthetases are enzymes converting neopterin to biopterin. Presented case indicates a possibility of erroneous classification of hyperphenylalaninemia due to BH4 deficit, if the complete differential diagnosis is not performed. A complete differential diagnosis is necessary in all cases of hyperphenylalaninemia distinguished in neonates during screening tests.

Alcohol Oxidoreductases↗