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T Maalouf

Publications and source records attributed to T Maalouf.

16 recordsLinked to original sources
PubMed2002

[Ocular involvement during primary central nervous system lymphoma].

PURPOSE: The aim of our study was to assess and to characterize the ocular involvement in patients with primary central nervous system lymphoma. POPULATION AND METHODS: We conducted a prospective study between August 1995 and December 1998 on a cohort of consecutive patients affected by primary central nervous system lymphoma and who underwent a systematic ophthalmological examination before treatment. RESULTS: The study population comprised 24 patients (mean age, 57 years; 16 women and 8 men). Among these patients, 6 had ocular involvement (2 patients with ocular signs revealing the cerebral process, 2 evidenced at the time of the initial ocular examination, and 1 as the disease evolved). Ocular involvement was vitritis in all cases, anterior uveitis in 1 patient, obliterant vasculitis in 1 patient and yellowish subretinal lesions in 1 patient. In 1 case, a vitrectomy led to adequate diagnosis of the disease. CONCLUSION: Our study shows a 25% incidence of ocular involvement in patients with primary central nervous system lymphoma, with posterior uveitis as the most common manifestation. Because of the relatively high incidence of ocular involvement, a systematic ophthalmological examination of this subset of patients should be mandatory.

Adult↗
PubMed2001

[Dilated cardiomyopathy and panuveitis as presenting symptoms of Lyme disease. General review of one case].

INTRODUCTION: The clinical expression of Lyme disease is highly variable. If a patient presents clinical findings consistent with a systemic Lyme borreliosis, this disease must be considered in an endemic area because of its favorable outcome with adequate treatment. EXEGESIS: The authors report and discuss the case of a patient with an unusual history of dilated cardiomyopathy and supraventricular fibrillation followed by bilateral panuveitis. Enzyme-linked immunosorbent assay and Western blot were positive for Borrelia burgdorferi antigens. The diagnosis of Lyme disease was made after other infectious, inflammatory and autoimmune disorders were excluded by clinical, instrumental and biological investigations. The treatment by ceftriaxone and amoxicillin resolved the ophthalmologic manifestations and improved the cardiac condition. CONCLUSION: This report underlines the possibility of an unusual presentation of Lyme disease. Ophthalmologic and cardiac involvement should be known by clinicians.

Adult↗
PubMed2001

[A full thickness macular hole as an uncommon complication of Behçet disease].

The authors report the occurrence of an unusual complication of Behçet's disease: a full thickness macular hole caused by retinal vasculitis resulting in a definite functional impairment. A review of the different ocular complications is provided, stressing the unusual location on the posterior segment and the potential seriousness of these complications.

Adrenal Cortex Hormones↗
PubMed2001

[Clinical course and prognosis of diplopias after orbital bony wall decompression for thyroid related orbitopathy].

INTRODUCTION: The aim of this study was to assess how oculomotor complications progress after orbital bony decompression for dysthyroid orbitopathy and to assess the residual risk of consecutive diplopia. MATERIAL AND METHODS: The medial orbital wall and floor were decompressed by a transpalpebral approach in 77 patients (117 orbits). Indications for decompression were optic neuropathy in 22 patients, exposure of the cornea in 1 patient, and cosmetic rehabilitation in 54 patients. Occurrence of oculomotor disorder after surgery was noted and the clinical course after a one-year follow-up was studied. RESULTS: Diplopia was observed in 34 patients (44%): 18 of these patients were treated by external orbital radiotherapy before surgery. Diplopia decreased spontaneously over a period ranging from 15 days to 2 months or was treated by adequate prism in 22 cases. A higher degree of diplopia (12 to 30 diopters) was noted in 12 cases, requiring surgical care that was successful in all cases. This progress was especially observed in patients with optic neuropathy or in patients who had been previously treated with external orbital radiotherapy. CONCLUSION: Prognosis of diplopia after bony wall decompression for thyroid-related orbitopathy can be favorable with spontaneous reduction, prism, or surgical treatment. Precise information should be given to the patients before surgery.

Adult↗
PubMed2001

[Gyrate atrophy and craniopharyngioma: a case report].

We report the case of a 13-year-old girl who developed a craniopharyngioma and a gyrate atrophy. No genetic link between these two diseases has ever been reported. This case recalls the characteristic features of gyrate atrophy.

Adolescent↗
PubMed2000

[Endogenous aspergillus endophthalmitis: a case repport].

We report a case of endogenous aspergillus endophthalmitis. This infection occurred in a young immunocompromised boy of 6 years old. The localisation of the chorioretinitis was unusual because out of the posterior area. The evolution was favorable with recovering of the visual acuity under general treatment and intravitreous injections.

Amphotericin B↗
PubMed1999

Place of radiotherapy in the treatment of Graves' orbitopathy.

PURPOSE: The aim of this study is to evaluate the response of Graves' orbitopathy to irradiation, and to specify the prognostic factors allowing one to better define the indications of orbital radiotherapy. METHODS AND MATERIALS: From 1977 to 1996, 199 patients received bilateral orbital irradiation delivering 20 Gy in 10 fractions and 2 weeks for a progressive Graves' orbitopathy. 195 patients were seen between 1 and 6 months after radiotherapy. The different symptoms were studied and their response to radiation was analyzed. Factors such as age, sex, evolution of thyroid disease, history of symptoms, and previous or combined treatments were analyzed. RESULTS: The results revealed that 50 patients (26%) had a good or excellent response, 98 (50%) had a partial response, 37 (19%) were stable, 10 (5%) had a progression of disease. The signs that best responded to radiotherapy were the infiltration of soft tissues and the corneal involvement. Responses of proptosis or oculomotor disorders were more complete when these signs were not advanced at the time of treatment. Irradiation seemed to have the same efficacy when applied as first-line treatment or after failure of corticosteroids. Neither modality of treatment of hyperthyroidism nor thyroid status at the time of orbital irradiation modified the results. The best results were recorded for early or moderately advanced presentation (p = 0.05). Patients treated within a delay of 7 months after the beginning of the ophthalmopathy had better responses than patients treated later (p = 0.10). CONCLUSION: Radiation therapy was successful in Graves' orbitopathy by stopping the progression of disease in almost all cases, by improving the comfort of patients, by obtaining objective responses, and by avoiding surgical treatments particularly when signs were moderate.

Adult↗
PubMed1999

[Complications of transpalpebral osseous orbital decompressions in thyroid orbitopathies].

INTRODUCTION: Complications of bony orbital decompression (BOD) are rather unreported and often neglected. The aim of this study was to assess the risks of this surgery. MATERIAL AND METHODS: 44 patients (76 orbits) were studied. There were 19 malignant orbitopathies and 57 cosmetic rehabilitations. All side-effects and true complications were reported. A questionnaire was send to the patient and to his ophthalmologist. RESULTS: Infra-orbital hypoesthesia, oculomotor disorders, entropion, changes of lid position were the most frequent complications. A case of hypoglobus, a case of lacrimal stenosis, a case of decreased visual acuity were reported. DISCUSSION: Side-effects of BOD are frequent. Higher rates are even found in the literature. These effects tend to decrease spontaneously or can be treated by adequate medical or surgical care. Some measures are proposed to perform surgery safer. CONCLUSION: More precise information should be given to the patients before surgery and a better prevention can be afforded.

Adult↗
PubMed1998

[Bicanaliculonasal intubation tubes covered with and without polyvinylpyrrolidone. Comparative study].

PURPOSE: To compare the efficacy and tolerance between silicone tube and treated polymer surface (PVP) tube of the bicanalicular intubation. METHODS: A randomized prospective study was performed in 50 patients (coated between March 96 and July 97) with chronic tearing. 25 classic intubations (silicone) and 25 with PVP was used. Intubations were performed for 2 months. Functional signs and objectives parameters at the medial canthus and the nasal mucous membrane were compared. RESULTS: There was no difference about functional signs between the 2 groups of patients. Objective signs (hyperemia, secretions) observed in the medial canthus and the nasal mucous membrane were less pronounced with the treated polymer surface tube. CONCLUSION: This study confirms the great potential of treated polymer surface tube.

Chronic Disease↗
PubMed1997

[Malignant non-Hodgkin lymphoma of the central nervous system with ocular site. Value of vitrectomy for diagnosis].

Diagnosis of intraocular lymphoma is difficult and should be considered in middle-aged or older patients with a chronic uveitis. Many explorations (lumbar punctures, brain imaging and vitrectomies) may be needed before correct diagnosis is made. We report the case of a 50-year-old woman with an intraocular lymphoma for whom the diagnosis was confirmed by a vitrectomy.

Central Nervous System Neoplasms↗
PubMed1996

[Effects of external orbital radiotherapy on the oculomotor muscle in Graves disease].

PURPOSE: Orbital radiotherapy is recognised to be effective in the treatment of acute Graves' disease. The effect on the oculomotor muscles is still controversial. MATERIAL AND METHODS: To assess this effect, we conducted a prospective study on 15 patients with acute Graves' ophthalmopathy. Patients were investigated before radiotherapy, 3 months later and at long term (mean = 2 years). To study the extent of the ophthalmopathy we chose the following criteria: class IV in the NOSPECS classification system, amplitude of gaze, measurement of the thickness of oculomotor muscles (CT-scan). RESULTS: Improvement of the amplitude of gaze and reduction of the thickness of oculomotor muscles were not statistically significant. The oculomotor disorder was unchanged 3 months after radiotherapy. After a long term follow up (mean: 2 years), only 5 patients, among those who complained of diplopia before radiotherapy, had to be operated, especially large deviations. CONCLUSION: Orbital radiotherapy does not appear as a direct treatment for oculomotor disorder in active thyroid related ophthalmopathy, however favorable indirect effects may be effective due to reduction of inflammation. As it is a harmless treatment, orbital radiotherapy may be proposed as primary treatment in active thyroid related ophthalmopathy.

Adult↗
PubMedDate not supplied

[Oculomotor risk after trans-palpebral bony decompression for thyroid-related orbitopathy].

PURPOSE: To study oculomotor disorders after transpalpebral bony orbital decompression (TPBOD) for dysthyroid orbitopathy. Pathophysiology, risk factors, preventive and therapeutic care were examined. MATERIAL AND METHODS: Forty-four patients were included in this retrospective study (76 orbits). Thirteen patients underwent surgery for severe orbital inflammation or optic neuropathy and 31 for cosmetic rehabilitation. 21 previously had orbital radiotherapy. Class IV of NOSPECS classification, primary position of gaze, diplopia and Lancaster coordimetry were studied comparatively pre and postoperatively. RESULTS: Diplopia appeared in 23.6% of the cases without deviation before surgery (tropia or phoria-tropia). Predictive factors were age and amblyopia whereas amount of retrodisplacement of the globe and radiotherapy were not. Lack of oculomotor restriction did not prevent from diplopia but may decrease its incidence. Unilateral decompression is more likely to create a vertical disorder. Pathophysiology is discussed. CONCLUSION: Oculomotor disorders can be explained by several mechanisms. Some of them can be prevented. Each patient should be aware of the risk of diplopia.

Adult↗