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Biomedical subjects

T Manthorpe

Publications and source records attributed to T Manthorpe.

9 recordsLinked to original sources
PubMed1987

Short stature as a possible etiological factor in anorexia nervosa.

The 21st case of concurrence of anorexia nervosa (AN) and gonadal dysgenesis (GD) or Turners syndrome is presented together with two more cases of AN in girls of short stature, but with normal chromosomes. The concurrence of AN and GD in the Danish population over a 10 year period is found not to be beyond the expected frequency. The possibility of low stature as such as an etiologic factor in AN is presented on the background of three cases. The same hypothesis has been suggested previously, but we cannot support the view of short stature as a common condition in AN patients premorbidly.

Anorexia Nervosa↗
PubMed1986

In vivo IgG deposits and reduced density of Langerhans cells in the surface epithelium of cervix uteri of patients with primary Sjögren's syndrome.

Intraepithelial IgG deposits have previously been demonstrated in epidermis and oral labial mucosal epithelium of patients with primary Sjögren's syndrome. IgG has been shown to be located to cell surface membranes predominantly of OKT6 positive Langerhans cells (LC), which moreover are decreased in number in epidermis of these patients. In biopsies of cervix uteri from 17 patients with primary Sjögren's syndrome and 21 controls, the mucosal membrane was examined with a direct immunofluorescence technique, for in vivo deposits of immunoglobulins, fibrinogen and C3c in the stratified squamous epithelium. Epithelial deposits of IgG, similar to that found in skin and oral labial mucosa, were demonstrated in 4/17 patients, but in none of the controls. No deposits of IgM, IgA, fibrinogen or C3c were found in the biopsies from either patients or controls. OKT6 positive mucosal LC were demonstrated with an indirect immunofluorescence technique, and enumerated in vertical sections. The density of epithelial LC was found to be decreased in patients (p less than 0.05) as compared to controls. No correlation was found between presence of IgG deposits and density of LC, in agreement with the findings in skin of these patients.

Adult↗
PubMed1975

Antihypertensive and hypertensive effects of the kidney. Elucidated by treatment with medullary transplants and with blockade either of the reninangiotensin-system or of the prostaglandin biosynthesis.

After subcutaneous isotransplantation of renal medulla either from normal donors or from the ischaemic kidney of renal two-kidney hypertensive rats, the blood pressure of the renal two-kidney hypertensive recipients was lowered-but not to normal levels. After i.v. injection of the converting enzyme inhibitor SQ 20,881, the blood pressure was further decreased to, or close to, normal blood pressure. A complete normalization of the blood pressure was obtained by the combined treatment with medullary transplants and infusions of the angiotensin II inhibitor Saralasin. The difference between the effects of these two blockers was probably caused by differences in the doses used. Administration of indomethacin, an inhibitor of the prostaglandin biosynthesis, to renal two-kidney hypertensive rats with or without renomedullary transplants failed to provoke a rise in blood pressure. This indicates that the anti-hypertensive activity of renomedullary transplants is not due to the group of prostaglandins, the synthesis of which is inhibited by indomethacin, and furthermore that these prostaglandins are not of importance to the blood pressure level in renal two-kidney hypertensive rats.

Angiotensin II↗
PubMedDate not supplied

Prophylaxis with lymecycline in induced first-trimester abortion: a clinical, controlled trial assessing the role of Chlamydia trachomatis and Mycoplasma hominis.

A clinical, controlled trial was performed to study the effect of prophylaxis with lymecycline and the role of Chlamydia trachomatis and Mycoplasma hominis in postabortal genital infection. Of 532 women who were to undergo first-trimester abortion, 269 were randomized to treatment with oral lymecycline (300 mg bid) starting 2 days before the abortion and continuing for a total of 7 days, and 263 were randomized to placebo treatment. The rate of postabortal infection was 9.3% in the antibiotic group and 9.5% in the placebo group, an insignificant difference (P greater than .8). The presence of C. trachomatis in the cervix/urethra at the time of abortion showed a significant association with the occurrence of postabortal infection (P less than .005), but there was no correlation between the effect of treatment and the presence of infection (P greater than .4). The presence of M. hominis, a history of pelvic inflammatory disease, maternal age, gestational age, the number of births, spontaneous and induced abortion, and the Hegar number showed no significant association with postabortal infection (all P values greater than .05). It is recommended that women who are to undergo induced abortion be examined for the presence of C. trachomatis and treated, as they constitute a risk group.

Abortion, Induced↗