PubMed Health⌕ Search

Biomedical subjects

T Mathew

Publications and source records attributed to T Mathew.

At least 19 recordsLinked to original sources
PubMed1992

Treatment of anaemia of progressive renal failure with recombinant human erythropoietin. A preliminary report.

We report response in anaemia and wellbeing of a lady with chronic renal disease treated with recombinant human erythropoietin 5000 units thrice weekly. Without any blood transfusions, the patient's haematocrit improved (20% to 35%) and a subjective improvement in wellbeing and appetite was noted. This drug seems to be a breakthrough in the management of anaemia of chronic renal diseases, including end stage renal disease, avoiding the risks of repeated blood transfusions.

Anemia↗
PubMed1992

Herpes zoster associated encephalitis.

Herpes zoster associated encephalitis is a very rare complication of herpes zoster. We are reporting a young healthy man who developed this complication along with the usual cutaneous presentation of herpes zoster. He was successfully treated with acyclovir.

Acyclovir↗
PubMed1989

Plasma concentrations of granulocytic elastase-alpha 1-proteinase inhibitor complex in patients with severe head injury, multiple trauma or cerebral bleeding.

In patients with severe head injury or multiple trauma a multitude of inflammatory mediators are released. As in cerebral bleeding, elevations of body temperature can be observed even in the absence of bacterial infections. In order to evaluate the diagnostic significance of plasma elastase levels for the exclusion or early detection of infections in the course of the above diseases, quantitative estimations of granulocytic elastase in complex with alpha 1-proteinase inhibitor were carried out in 11 patients using an enzyme-linked immunoassay over a period from 3 to 47 days. Additionally, leukocyte counts were made and body temperatures measured. In all but two cases, elastase levels were elevated at the beginning of the disease and usually decreased over the period of study. In contrast to leukocyte counts and body temperature, the values correlated with the severity of the clinical symptoms. It is concluded that plasma elastase determinations are useful in the differential diagnosis of infection from other causes of elevated body temperatures.

Blood Cell Count↗
PubMed1988

Comparison of three immunosuppressive regimens in cadaver renal transplantation: long-term cyclosporine, short-term cyclosporine followed by azathioprine and prednisolone, and azathioprine and prednisolone without cyclosporine.

We conducted a randomized trial in seven Australian hospitals of the efficacy and safety of three immunosuppressive regimens after first transplantation of a cadaver kidney: long-term cyclosporine, short-term (three months) cyclosporine followed by azathioprine and prednisolone, and azathioprine and prednisolone without cyclosporine. Patients assigned to long-term cyclosporine (n = 138) or short-term cyclosporine followed by azathioprine and prednisolone (n = 141) had similar actuarial 12-month survival (98.4 vs. 96.4 percent) and graft survival (83.9 vs. 82.1 percent). Patients assigned to receive only azathioprine and prednisolone (n = 138), with optional use of antithymocyte globulin, had a significantly poorer survival rate (91.3 percent, P = 0.015) because of deaths from cardiac causes and infection, but their graft survival of 76.0 percent (P = 0.31) did not differ significantly from that of either group receiving cyclosporine. After the switch from cyclosporine to azathioprine and prednisolone, 15 percent of patients had reversible rejection episodes, but the frequency of rejection and graft loss did not differ from that in the long-term cyclosporine group. After the change to azathioprine and prednisolone, serum creatinine levels declined in nearly all patients, so that after three months they were comparable to those in the group receiving azathioprine and prednisolone only, and significantly lower than those in the group receiving long-term cyclosporine therapy (P less than 0.003). We conclude that the two cyclosporine regimens result in comparable patient and graft survival, but that changing to azathioprine and prednisolone at three months improves graft function.

Adult↗
PubMed1986

Isolation, cultivation and haemadsorption of buffalo pox virus on BHK-21 cell line from Dhule epidemic (Western India).

An epidemic of buffalo pox infection in buffaloes, white cattle, horses, goats and human beings in the Dhule district of Maharashtra State (India) during December, 1975 to March, 1976 is reported. Buffalo pox virus from this epidemic has been propagated in BHK-21 cell line directly from the skin scab materials collected from those animals in phosphate glycerine buffer. A specific cytopathic effect (CPE) produced in these cell lines was differentiated from the non-specific CPE by the demonstration of the characteristic 'Rosette' or 'Sun flower' like haemadsorption with 0.4% fowl erythrocytes. The CPE started appearing as early as 18 hours and the detachment and peeling off the cells from the glass surface were noted on the 4th day onwards. Eosinophilic inclusion bodies with giant cells (multi-nucleated) formation and fusion of the cells were also observed with a few stellate cells.

Animals↗
PubMed1984

Two-dimensional and Doppler echocardiographic evaluation of aortic aneurysm and dissection.

Ten patients with nondissecting aortic aneurysm and 10 with aortic dissection proved by angiography, surgery or both, were studied by real-time, 2-dimensional echocardiography. Multiple transducer positions were used to visualize various aortic segments so that a composite image of the aorta could be formulated. Using this comprehensive approach, the site, size and extent of all nondissecting aneurysms were correctly delineated (2 ascending aorta, 3 ascending aorta plus aortic root and 5 aortic arch with brachiocephalic involvement). In all patients with aortic dissection, the condition was identified by the presence of prominent, flap-like, undulating motion of the inner dissected wall or marked parallel wall widening (greater than or equal to 15 mm) and correctly categorized into DeBakey type I (4 cases), II (2 cases) or III (4 cases). Pulsed Doppler studies were useful in diagnosing reopening of dissection in a patient with previous surgical obliteration of the false channel.

Adult↗
PubMed1982

Evidence supporting neural crest origin of an alveolar soft part sarcoma: an ultrastructural study.

A case of an alveolar soft part sarcoma was studied electron microscopically. This showed tumor cells separated by external lamina that incorporated desmosome-like structures. Well defined basal lamina separated several cells from underlying endothelial cells by a zone of tissue composed predominantly of fibrous long-spacing collagen. A unique finding was the presence within several tumor cells of well defined myelin sheaths and myelinated axons. Apart from various other intracellular organelles some of the cells contained closely aggregated fine filamentous structures: the so-called "angulate bodies." All these findings are interpreted as evidence for a tumor showing marked Schwann cell differentiation, and therefore, it is suggested that alveolar soft part sarcoma is histogenetically a neoplasm of the neural crest.

Adult↗
PubMed1981

Isoantigens A, B and H in primary liver malignancies.

Formalin-fixed tissues from 37 cases of primary liver malignancies were investigated by the technique of Specific Red Cell Adherence (SRCA) for studying the presence or absence of blood group isoantigens A, B and H. These tumours comprised 15 cases of hepatocellular carcinomas, 5 hepatoblastomas, and 17 cholangiocarcinomas. Results of the SRCA were consistently negative in all hepatocellular carcinomas and hepatoblastomas. Fifteen of 17 (88%) cholangiocarcinomas gave a positive SRCA, but no correlation could be obtained between the intensity of the reaction and their histological grading or metastatic potential. Reasons are given for the negative reactions in hepatocellular carcinomas and hepatoblastomas, an possible explanations are offered for the high rate of positivity in cholangiocarcinomas. It is concluded that the inherent properties of these 3 tumours limit the application of the SRCA procedure as a potential gauge of prognosis.

ABO Blood-Group System↗
PubMed1981

Osteosarcoma of the testis.

We studied a unique case of osteosarcoma of the testis. The tumor either originated from indifferent mesenchymal cells, or it represents a one-sided monomorphic development of a teratoma.

Humans↗
PubMed1980

Ground-glass cells in hepatocellular carcinoma.

Hematoxylin and eosin-stained sections representing ten cases of hepatocellular carcinoma showed many tumor cells with ground-glass cytoplasm identical to that found in hepatocytes containing hepatitis B surface antigen (HBsAg). However, the aldehyde fuchsin stain was negative, as were the were the immunoperoxisidase stains for HBsAg and core antigen (HBcAg). Electron microscopically, the ground-glass appearance corresponded to the presence of non-membrane-bound amorphous or fibrillar inclusions. Immunohistochemically, the ground-glass material reacted with antiserum to human fibrinogen, suggesting synthesis of this protein by the carcinoma cells. Although the ground-glass appearance in hepatocellular carcinomas may sometimes be associated with HBsAg, special stains or technics are necessary to confirm its presence.

Adolescent↗