Review of cerebral edema.
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Abducens Nerve↗
Biomedical subjects
T Mathews
Publications and source records attributed to T Mathews.
Molecular characterization of the smallest secondary constriction region (qh) of human chromosome 16.
We report the smallest secondary constriction region (h) in human chromosome 16. The cytochemical, cytogenetic, and molecular techniques revealed the complex heterogeneity of heterochromatin observed in this region. The heteromorphisms can be found due to the variation in centromeric (c) region alone or in combination with the h region. Routine selective staining techniques fail to differentiate the C region from the h region. However, the fluorescence in situ hybridization technique clearly demonstrated that the centromere of chromosome 16, which is composed of 340-base-pair dimers arranged in a tandem array of 1.7-kb higher-order repeat units, is not heteromorphic in the present case, but other molecular cytogenetic techniques demonstrated the presence of a very small h region. The evolution of heterochromatin of this region is discussed.
Centromere↗
Chromosomal anomalies in 1,000 children referred with suspected genetic disorders.
One thousand children ranging from newborns to 13 years of age with a variety of clinical disorders were referred to us to investigate the possible presence of chromosomal abnormalities. Various types of chromosomal anomalies were found in 166 children (16.6%), which is significantly (p < 0.01) higher than in an unselected (control) population (0.48-0.55%). The male:female ratio was 3:2 for the total population. Furthermore, in our survey population, the sex ratio of Down's syndrome cases of males to females was 3:2.
Child↗
Epidemiology of neuroleptic malignant syndrome.
The authors reviewed the trends in the incidence of neuroleptic malignant syndrome (NMS) in studies recently reported in various countries. Possible reasons for the differences in reported incidences were considered. The authors identified publications in English (and their cross-references) that estimated the incidence of NMS with a retrospective or prospective design. They compared the incidence in studies from the United States with those from other countries. The initial retrospective studies from the United States reported higher incidence rates of NMS than did similar studies from elsewhere. More recent prospective studies from the United States report a much lower incidence. Neuroleptic malignant syndrome remains a rare complication of psychotropic treatment if the syndrome is defined stringently. The high incidence reported in earlier studies in the United States can be explained by retrospective study design, loose diagnostic criteria, adherence to an amorphous "spectrum concept," and clinical practices in vogue.
Humans↗