Biomedical subjects
Publications and source records attributed to T Mattsson.
Finland was the world's main producer of anthophyllite asbestos between 1918 and 1975. The total amount of mined anthophyllite asbestos was 350,000 tons of which 230,000 tons were exported. Anthophyllite quarry workers who had worked at least five years between 1936 and 1972 showed the highest risk of asbestosis, in comparison with other groups of asbestos workers.
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Radiographic and respiratory functional findings are reported for a series of 133 Finnish patients with asbestosis. Of these patients, 65 (49%) were found to have radiographically mild diffuse pulmonary fibrosis (profusion 0/1, 1/0 or 1/1), 48 (36%) moderate fibrosis (1/2, 2/1 or 2/2) and 20 (15%) diffuse fibrosis in an advanced stage (2/3 or more). The type of fibrosis was mostly irregular (110 = 83%). Fibrosis was typically the most advanced in the lower zones of the lungs. Of the 133 patients, 88 (66%) showed pleural changes and 78 (59%) pleural calcifications. The more severe the fibrosis, as seen in the radiographs, the greater the decrease in vital capacity (VC) and expiratory volume in 1 s (FEV1.0). Transfer factor was generally impaired only in advanced cases of asbestosis (fibrosis 2/3 or more). In general, obstruction was not observed in this series. Pleural changes seemed to decrease VC and FEV1.0 when the fibrosis was mild (0/1, 1/0 or 1/1). They had no effect on diffusion capacity (TLco).
The amount and distribution of the welding fume lung contaminants was measured in 44 arc welders from two shipyards. The measurement was made from the determination of the permanent field after the subject was magnetized in a low external magnetic field, the values being used for the calculation of the amount of contaminants in the lungs. Less than 4 mg of dust was found in the lungs of nonexposed controls. In the shipyard welder's lungs, after two years of exposure, on the average 7 mg (range 4-15) of welding dust was observed. After a continuous exposure of about 18 years the amounts were 200 mg (range 30-1,500) in shipyard A and 700 mg (150-2,000) in shipyard B, respectively. On the basis of data obtained from retired welders, the clearance rate of 45% in welders from shipyard A and 18% in shipyard B were calculated, the latter figure being probably more accurate. The distribution of contaminants was 52% in the right and 48% in the left lung. The radiological findings correlated well with the amounts of welding fume contaminants measured with the magnetic method.
Conventional and magnification angiography were performed on 34 occasions in 31 patients with renal allografts. The differential diagnosis between acute rejection and tubular necrosis was uncertain. In chronic rejection, where vascular abnormalities dominate, the diagnosis was easier. The magnification angiography demonstrated the small intrarenal arteries to better advantage, resulting in a more accurate assessment of the condition.
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A series of 202 patients with stage I and II carcinoma of the cervix uteri is presented. Radical hysterectomy and pelvic lymph node dissection was performed in all cases and most patients received radiotherapy in addition. The condition at 5-year follow-up of all patients is reported and the facts associated with operative complications are analysed. Special attention was paid to the urological condition by performing urographies as a routine study both pre- and postoperatively. There was a strong correlation between the pathological postoperative urologic finding in regard to poor prognosis and permanent complications. Urinary tract infections occurred frequently and were difficult to handle. The operations performed for urological complications are listed. It is concluded that the treatment of carcinoma of the cervix uteri should be concentrated on clinics with a well-trained staff. At every stage of treatment intensive teamwork is most important. The rate of complications can be reduced by intensifying studies especially in the postoperative period. New diagnostic procedures and prophylactic measures should be tried andintroduced into routine practice if proved valuable. It is important that major surgery, such as radical hysterectomy, be performed in a teaching hospital for gynecologists.
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One hundred and forty-eight (72%) of 205 allogenic bone marrow transplant recipients developed mucosal lesions in the oral cavity during the aplastic period after transplantation. Lesions were most frequent 8 to 9 days after transplantation. Factors that correlated with the development of mucosal lesions after univariate and multivariate analysis were a marrow cell dose of less than 3 x 10(8) cells/kg body weight, (p less than 0.0001), prolonged aplastic period (white blood cell count less than 0.2 x 10(9) cell/l during more than 14 days (p less than 0.005), herpes simplex virus-1 seropositivity of the recipient (p less than 0.01), and conditioning with total body irradiation (p less than 0.02).