T McMurray | PubMed Health

PubMed1993

Thermal damage quantification utilizing tissue birefringence color image analysis.

Decreased connective tissue or cardiac muscle birefringence in transmission polarizing microscopy is an observable measure of damaged tissue concentration. Accordingly, histologic monochrome images of thermally damaged tissue exhibiting decreased birefringence provide important information about the tissue thermal history. Thus, a damage quantification algorithm based on monochrome tissue images exhibiting decreased birefringence has been developed providing tissue damage values corresponding to estimated temperature distributions. In addition, utilizing 24-bit true color tissue images, epicardial birefringence color variations resulting from thermal exposures may also be observed. Therefore, image segmentation methods are used on the red, green, and blue color image components to isolate the epicardium, similarly allowing damage quantification on this tissue constituent.

Algorithms↗

PubMed1981

Cyclic nucleotides and aggressive behavior.

Cyclic nucleotides, particularly cyclic AMP, have been implicated as second messengers in neuronal activity. Attempts to demonstrate an association between endogenous cAMP or cGMP levels and rodent aggressive behavior have been only partially successful. Low levels of cAMP in rodent brain appear associated with lower levels of affective aggression. Consistent with this possible relationship is our finding that the infusion of dibutyryl cAMP into rodent cerebroventricles decreases aggressive behavior. The infusion of dibutyryl cyclic GMP, conversely, facilitates shock-induced fighting in the rat.

Aggression↗