Ocular complications associated with bungee jumping.
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Adult↗
Biomedical subjects
T Mears
Publications and source records attributed to T Mears.
Rhinosporidiosis.
Rhinosporidiosis is the disease resulting from infection by Rhinosporidium seeberi, an organism endemic in the Indian sub-continent, but rarely seen in the United Kingdom. We describe the clinio-pathological features of a case presenting in a 14-year-old female.
Adolescent↗
An adenoviral vector system for functional identification of nuclear receptor ligands.
A recombinant adenovirus system has been designed that confers glucocorticoid responsiveness upon infected cells in culture. Two mutually dependent viruses are required: a trans-activator virus containing the human glucocorticoid receptor transcription unit and a second receptor virus harboring a glucocorticoid response element linked to the firefly luciferase gene. Another reciprocal pair of viruses has been generated; one member expresses the rat thyroid hormone receptor alpha, while the other contains the luciferase gene regulated by a thyroid hormone-responsive DNA element. Corticosteroid- or thyroid hormone-induced transcription can be efficiently and accurately quantitated from cells coinfected with the appropriate complementary virus pair 20 h after infection in 96-well microtiter plates. This coinfection assay offers a convenient way to measure transcriptional activation by nuclear receptors and has certain key advantages over the commonly used cotransfection method. Its sensitivity and precision make it a practical approach to rapidly identify substances extracted from complex biological samples activating candidate "orphan" nuclear receptor molecules.
Adenoviridae↗
Giardia lamblia as parasite in humans.
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Adult↗
Symptomatic cervical oesophageal ectopic (heterotopic) gastric mucosa treated with omeprazole.
A 60-year-old female patient with a 3-year history of nausea underwent oesophagogastroduodenoscopy. Red lesions were found in the cervical oesophagus: one of 2 cm and the other less than 1 cm. These lesions were biopsied and the larger lesion showed typical gastric mucosa. Following 40 mg/day omeprazole for 3 days all symptoms disappeared. Treatment was stopped after the patient remained symptom-free for 4 weeks.
Choristoma↗