Biomedical subjects

T Meguro

Publications and source records attributed to T Meguro.

165 records · Page 10Linked to original sources

PubMedDate not supplied

A simple and rapid test for PIVKA-II in plasma.

A simple and rapid assay for the detection of PIVKA-II is described. The principle of the assay is based on agglutination of antihuman prothrombin rabbit IgG coated latex with absorbed plasma which is treated with barium carbonate. This assay is expected to be useful as a screening test to differentiate whether or not vitamin K deficiency is present in various clinical cases such as newborn infants, patients with liver diseases, disseminated intravascular coagulation, and so on.

Adult↗

PubMedDate not supplied

Mercury uptake in vivo by normal and acatalasemic mice exposed to metallic mercury vapor (203Hg degrees) and injected with metallic mercury or mercuric chloride (203HgCl2).

Levels of mercury in the brain and liver of acatalasemic mice immediately following exposure to metallic mercury vapor or injection of metallic mercury were higher than those found in normal mice. Acatalasemic mice had decreased levels of mercury in the blood and kidneys when the levels were compared with those of normal mice, which indicated that catalase plays a role in oxidizing and taking up mercury. Thus, the brain/blood or liver/blood ratio of mercury concentration in acatalasemic mice was significantly higher than that of normal mice. These results suggest that metallic mercury in the blood easily passed through the blood-brain or blood-liver barrier. The levels of mercury distribution to the kidneys of normal and acatalasemic mice, 1 hr after injection of mercuric chloride solution, were higher than that of normal and acatalasemic mice, respectively, 1 hr after injection of metallic mercury.

Animals↗

PubMedDate not supplied

Reduction of mercuric ion and exhalation of mercury in acatalasemic and normal mice.

A significant difference in the amount of exhaled mercury per hour between normal and acatalasemic mice was observed in 7 of 11 experiments for different periods of time. The total amount of mercury exhaled from acatalasemic mice was significantly higher than those of normal mice. The results confirm that the reduction of mercuric ion to metallic mercury occurs by recycling of mercury in the tissues and reoxidized metallic mercury to mercuric ion by catalase. Mercuric ion was reduced to metallic mercury in the presence of superoxide anion in vitro. The reduction rate of mercuric ion to metallic mercury in the presence of both superoxide anion and cytochrome C or nitro blue tetrazolium was higher than that in the presence of superoxide anion alone, and the reduction of mercuric ion by NADPH or NADH was also observed. The reduction of mercuric ion to metallic mercury by liver homogenates of acatalasemic mice was higher than that of normal mice.

Acatalasia↗