PubMed Health⌕ Search

Biomedical subjects

T Meguro

Publications and source records attributed to T Meguro.

At least 127 records · Page 7Linked to original sources
PubMed1987

Maximal expiratory flow-volume patterns in allergic rhinitis. Characteristic flow-volume patterns of the lower airways.

On 37 patients with nasal allergy and 37 non-smoking healthy volunteers, maximal expiratory flow-volume curve and volume-time curve were obtained. To find the characteristic flow changes, the flow curves were classified into five patterns from type A to type E. The results showed that the incidence of type A was significantly lower in patients with nasal allergy than in the control group, while the rate of type E was significantly higher at 46% and the rate of type B was particularly high (32.4%) in the patient group. It was demonstrated that 77% of the subjects provided B or C flow-volume curves, while those with pale nasal mucous membranes developed D and E formats. In patients with nasal allergy, these patterns are useful in diagnosing remarkable differences in the lower airways.

Adolescent↗
PubMed1986

Influence of granulocyte elastase-like proteinase (ELP) on platelet functions.

The influence of granulocyte elastase-like proteinase (ELP) on platelet functions was investigated. ELP inhibited the platelet aggregations induced by a wide variety of agonists. The inhibition was marked in the case of receptor-mediated agonists such as thrombin, ristocetin, etc. It was moderate with the pervading agonist, arachidonic acid, and mild with the bypassing agonist, Ca2+ ionophore A23187. ELP inhibited the release of thromboxane A2 from platelets in the case of the platelet aggregation induced by thrombin. On the other hand, ELP did not inhibit the release of thromboxane A2 from platelets in the platelet aggregation induced by arachidonic acid or Ca2+ ionophore A23187. ELP suppressed the release of serotonin from platelets induced by thrombin, while it did not markedly suppress the release of serotonin induced by Ca2+ ionophore A23187. Treatment of platelets with ELP resulted in a slight increase of intraplatelet cAMP levels. These results suggest that ELP acts on receptors and inhibits platelet functions. As a results, ELP markedly inhibits the platelet functions such as aggregation or release of serotonin or thromboxane A2 stimulated by receptor-mediated agonists. ELP slightly elevates the cAMP level in the platelets, resulting in the mild inhibition of the platelet functions stimulated by the pervading agonist, arachidonic acid, or the bypassing agonist, Ca2+ ionophore A23187.

Adenosine Diphosphate↗
PubMed1986

Selection of effective maximal expiratory parameters to differentiate asthmatic patients from healthy adults by discriminant analysis using all possible selection procedure.

Maximal expiratory volume-time and flow-volume (MEVT and MEFV) curves were drawn for young male nonsmoking healthy adults and for young male nonsmoking asthmatic patients. Eleven parameters, two MEVT (%FVC and FEV1.0%), six MEFV (PFR, V75, V50, V25, V10 and V50/V25), and three MTC parameters (MTC75-50, MTC50-25 and MTC25-RV) were used for the multivariate analysis. The multivariate analysis in this study consisted of correlation coefficient matrix computation, the test for mean values in the multivariates, and the linear discriminant analysis using the all possible selection procedure (APSP). Correlation coefficients among flow rate parameters and flow rate related parameters in high lung volumes were different between the two groups. In the eleven-parameter discriminant analysis by APSP using single parameters, PFR, V75 (flow rate at 75% of forced vital capacity), and FEV1.0% were considered to be the effective parameters. In the seven-parameter discriminant analysis using the parameter groups, the group of all parameters and the %FVC and flow rate-related parameter group were considered to be the effective numerical alternatives to MEFV curves discriminating between healthy adults and asthmatic patients.

Adult↗
PubMed1986

Foetal distribution of inhaled mercury vapor in normal and acatalasaemic mice.

Levels of mercury distribution in placenta, amniotic sac and foetus and those in brain and liver of maternal acatasaemic mice were higher than those of normal, respectively. The levels of mercury distribution in the blood and lungs of maternal acatalasaemic mice exposed to metallic mercury vapor were also lower than those of normal. Mercury concentrations in placenta and foetus of acatalasaemic mice following exposure to metallic mercury vapor were higher than those of normal. Maternal acatalasaemic mice had decreased levels of mercury in the blood than those of normal mice. Thus, the placenta/blood or foetus/blood ratio of mercury concentration in acatalasaemic mice was significantly higher than that in normal mice. Similarly the brain/blood or liver/blood ratio of maternal acatalasaemic mice was higher than that of normal mice. These results suggest that metallic mercury in the blood readily passed through the blood-brain, blood-foetus barriers. In contrast to the results on exposures of mice to metallic mercury, the foetus/maternal blood ratio of mercuric concentration in the acatalasaemic mice following injection of mercuric chloride was similar to that in the normal mice. Moreover, the foetus/maternal blood ratio of mercury concentration in acatalasaemic or normal mice injected with mercuric chloride was lower than those in acatalasaemic or normal mice exposed to metallic mercury.

Acatalasia↗
PubMed1983

Maximal expiratory flow-volume patterns in airway allergy.

We considered upper and lower airway allergies as different phases of airway allergy and MEFV patterns to vary according to the intensity of airway obstruction in maximal expiratory flow-volume and volume-time tests on fourteen patients with nasal allergy, two with allergic bronchitis, two with bronchial asthma, and sixteen nonsmoking healthy subjects. In nasal allergy, flow changes during high lung volumes were different from those in allergic bronchitis and bronchial asthma, and MEFV patterns in nasal allergy were more widely varied than those in allergic bronchitis and bronchial asthma. We classified MEFV patterns into five ones.

Forced Expiratory Flow Rates↗
PubMed1983

Discriminant analysis of pulmonary function parameters--mild asthmatics versus moderate asthmatics--.

Maximal expiratory volume-time and flow-volume (MEVT and MEFV) curves were constructed from the measurements of young male nonsmoking, mild and moderate asthmatic patients (mean age, 29.7 yrs.). Eleven parameters of the pulmonary function tests, two MEVT, six MEFV, and three mean time constant (MTC) parameters, were calculated from the curves. These parameters were used in 15 analyses through the all possible selection procedure (APAP) discriminating between mild and moderate asthmatics. The probability of misclassification was computed with each of the eleven parameters, and all eleven probabilities thus obtained were compared with each other. This procedure showed us that the probability of misclassification ranged from 30.83% to 45.40% and that the most useful parameter was MTC50-25. The probability of misclassification computed using all eleven parameters (total parameter group) was 15.90%. The discriminant analysis indicated that the flow-volume patterns varied according the severity of bronchial asthma, thus, the flow-volume curve was considered to be important in analyzing the severity of bronchial asthma.

Adult↗
PubMed1983

Classification of potentially toxic chemicals based on their effects on mitochondrial respiration.

The classification of potentially toxic chemicals including environmental pollutants was made with respect to state 3 and state 4 respiration of mitochondria. The concentration of certain metals for 50% inhibition of respiratory control index (RCI; state 3/state 4) was lower than that of organic compounds tested. Various chemicals including environmental pollutants were classified into four groups by combination of effects on state 3 and state 4 respiration.

Animals↗
PubMed1982

Discriminant analysis of pulmonary function parameters. Healthy adults versus mild asthmatics and moderate asthmatics.

Volume-time (V-T) and flow-volume (F-V) curves were measured in all the subjects of nonsmoking young males (mean value 26.3 yrs. of age), healthy and asthmatics. Eleven parameters of pulmonary function tests composed of two V-T, six F-V, and three mean time constant (MTC) parameters, were calculated from the curves. These parameters were used in the two analyses through the all possible selection procedure (APSP) discriminating between healthy adults and mild asthmatics and also between healthy and moderate. Flow rate at 75% of FVC (V75) proved to be the most useful parameter and V50 the next best in both analyses. The probability of misclassification using all eleven parameters was 19.64% in the analysis of healthy adults and mild asthmatics, and 4.29% in the analysis of healthy adults and moderate asthmatics. There was a little difference in the parameters selected at every step. The discriminant analysis proved that the flow-volume patterns were different according to the severity of bronchial asthma. Thus flow-volume recognition was considered to be important in analyzing the severity of bronchial asthma.

Adult↗
PubMed1982

Discriminant analysis of volume-time and flow-volume parameters between healthy adults and asthmatic patients.

Volume-time (V-T) and flow-volume (F-V) curves were measured in all the subjects of nonsmoking young males (mean value 26.3 yrs.), healthy and asthmatic. Eleven parameters of pulmonary function tests, which were composed of two V-T, six F-V, and three mean time constants (MTC) parameters, were calculated from the curves. These were used in the discriminant analysis through all possible selection procedures (APSP) to make clear the importance of the F-V recognition. In using only one parameter, V75, which was one of the F-V parameters, showed the lowest probability of misclassification, 18.78%, and was the most useful parameter to discriminate the two groups. The probability of misclassification of the eleven parameters showed 15.46%, and that of the six F-V ones showed 17.45%. Though the probability of the six F-V ones was higher than that of the eleven ones, it was lower than that of the twoV-T or of the three MTC ones. Therefore the six F-V parameters including V75 was sufficient to discriminate the two groups of subjects. Thus it was made clear that the flow-volume recognition was important by the discriminant analysis.

Adult↗