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T Michalak

Publications and source records attributed to T Michalak.

At least 37 records · Page 2Linked to original sources
PubMed1977

Autoantibodies in sera of rabbits immunized with influenza virus.

Rabbits immunized with purified influenza A (H3N2) virus within 4 weeks developed autoantibodies of SMA type (smooth muscle antibodies). In some of them also ABBA (antibodies against brush border of proximal renal tubuli) and ANA (anti-nuclear antibodies) were detected. This autoimmune response was found to be unrelated to either the virus dose or the adjuvant used for immunization. Autoantibodies were not parallel in titre with influenza antibody.

Animals↗
PubMed1976

Electron microscopic and radioisotopic studies on cap formation in Toxoplasma gondii.

Trophozoites of Toxoplasma gondii from mouse peritoneal exudate are capable of shedding antibodies with which they have been previously coated. The antibodies are first moved towards the anterior pole of the parasite, at which they form a "cap". From the pole they are shed into the environment in the form of antigen-antibody complexes. An internalization of the accumulated material has never been encountered. Most probably, the observed phenomenon reflects a mechanism by which the parasite evades the host's immune response.

Animals↗
PubMed1976

Autoantibodies in sera of influenza patients.

Sera of the influenza patients and healthy controls were tested for some types of autoantibody (SMA, ANA, ABBA, AMA). They were detected in 83.8% of the patients' sera and in 16.6% of controls. SMA were present in 77.4%, ANA in 54.8%, and ABBA in 16.1% of the patient's sera. AMA were not detected. A majority of the sera contained more than one autoantibody type. The possible mechanisms of induction of the autoantibodies in virus infection and their possible role in disease are briefly discussed.

Actomyosin↗
PubMedDate not supplied

Abdominal aortic aneurysm: association between haptoglobin phenotypes, elastase activity, and neutrophil count in the peripheral blood.

To investigate the role of genetic factors on susceptibility to atherosclerotic arterial disease, the influence of haptoglobin phenotypes (Hp) on serum elastase activity, neutrophil count, and elastin concentration in the aorta was measured in patients with abdominal aortic aneurysm (AAA; n=52) and aortoiliac atherosclerotic occlusive disease (AOD; n=37). Findings (serum elastase activity, peripheral blood neutrophil count) were compared to a control group (CG) of 37 subjects without atherosclerosis. Hp phenotyping performed by starch-gel electrophoresis produced a haptoglobin-hemoglobin complex of three phenotypes: Hp1-1, Hp2-2, and Hp2-1. Distribution of Hp phenotypes was similar in the three study groups (AAA, AOD, CG). Significant increases in serum elastase activity and neutrophil count was measured in Hp2-1 phenotype of AAA patients. Although the aorta wall of aneurysm patients contained less (p<0.001) elastin than that of AOD patients, no significant difference of aorta elastin concentration between the three Hp phenotypes, including Hp2-1, was measured. The postulated association of AAA susceptibility with Hp2-1 phenotype was supported by the study data that demonstrated an increase in serum elastase activity in patients undergoing AAA repair.

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