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Biomedical subjects

T Mihara

Publications and source records attributed to T Mihara.

At least 73 records · Page 4Linked to original sources
PubMed1986

Congenital aplasia of the extensor muscles of the fingers and thumb associated with generalized polyneuropathy: an autosomal recessive trait.

Three sibs born to normal but consanguinous parents had flexion deformities of the thumb and fingers on one hand and sensory deficit in the other hand. Extensor muscles were absent or vestigial in all of them. Polyneuropathic electrophysiological findings were detected in 4 limbs. This is an apparently autosomal recessive trait previously unreported.

Contracture↗
PubMed1986

Mortality of Japanese diabetics in a seven-year follow-up study.

To clarify the prognosis of Japanese diabetics, 143 patients with IDDM, 3394 with NIDDM and 384 with IGT who had visited the Diabetes Center of the Tokyo Women's Medical College from 1976 through 1980 were followed up during 3-7 years. The follow-up rates of the patients with IDDM, NIDDM and IGT were 100.0%, 99.6% and 99.7%, respectively. The mortality rates per 1000 person-years among the patients with IDDM, NIDDM and IGT were 8.73%, 25.24 and 13.72, respectively. On the other hand, the ratios of observed number of deaths among diabetics to expected number of deaths among a sex- and age-matched general population were 3.39 in IDDM, 1.55 in NIDDM and 1.03 in IGT. The leading cause of death in IDDM was acute cardiac failure and in both NIDDM and IGT, malignant neoplasms. In NIDDM, a statistically significant excess of deaths from diabetes mellitus itself, ischemic heart disease and malignant neoplasms was observed compared with the general population. This is the first report concerning mortality and causes of death among Japanese diabetics separately for IDDM, NIDDM and IGT.

Adult↗
PubMed1983

Prevalence of diabetic microangiopathy and neuropathy among Japanese diabetics in the Tokyo area: related to the WHO new diagnostic criteria.

In accordance with the new criteria for diabetes mellitus proposed by the WHO in 1980, patients treated at our clinic from 1976 to 1980 were examined for diabetes mellitus and its three major complications. 3809 patients (M 2176, F 1630) were divided into three groups: DM-A group (2912) with fasting plasma glucose (FPG) greater than or equal to 140 mg/100 ml; DM-B group (334) with FPG less than 140 and 2 hr after load (2H) greater than or equal to 200; IGT group (563) with FPG less than 140 and 140 less than or equal to 2H less than 200. The prevalences of the three complications are presented in the order: DM-A; DM-B; IGT, 33%; 21%; 15% (proteinuria), 48%; 28%; 18% (retinopathy), 63%; 47%; 34% (neuropathy), 15%; 6%; 1% (triopathy). Among the diabetics groups (DM-A + DM-B), prevalence of retinopathy is examined by sex, known duration of diabetes and age at registration. Prevalence is 45% in male, and 47% in female; duration 0-2 yr 27%, 3-5 yr 37%, 6-8 yr 50%, 9-11 yr 59%, 12-14 yr 68%, 15 yr- 73%; age at registration 0-24 yr 23%, 25-44 yr 39%, 45-64 yr 50%, 65 yr- 47%. On crosstabulation of age and duration in 25-44 yr age group, the prevalence of retinopathy as a function of known duration is 22% (duration 0-2 yr), 29% (3-5 yr), 53% (6-8 yr), 62% (9-11 yr), 73% (12-14 yr), 90% (15 yr-) and the prevalence rises more steeply than elder ones.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

Mortality and causes of death among Japanese diabetics in the Tokyo area: prospective follow-up study over four years.

To clarify the mortality and causes of death among Japanese diabetics, we started a prospective follow-up study of 1,629 diabetics who had been registered at our Diabetes Center in 1976. After registration, all patients were checked annually for four years and we confirmed that they were still alive by sending questionnaires or obtaining copies of their resident cards. After a four-year follow-up, only 3 had dropped out, 1,486 were alive and 140 had died. The follow-up rate therefore was 99.8%. We obtained copies of the death certificates of all the deceased. It was shown that risk factors increasing the mortality ratio (the ratio of observed deaths to expected deaths) among Japanese diabetics were early onset of diabetes (0-29 years of age), treatment by insulin and the presence of diabetic retinopathy combined with proteinuria at registration. The most frequent cause of death among the 140 deceased cases was malignant neoplasm, the second ischemic heart disease and the third was cerebrovascular disease. Analysis of the underlying causes of death showed a significant increase in the death rate due to diabetes mellitus and ischemic heart disease among Japanese diabetics compared with the general population matched for sex and age.

Diabetes Mellitus↗
PubMed1982

[A giant chondromyxoid fibroma originated from the right orbital roof.--A case report--].

The authors reported a case of giant chondromyxoid fibroma of the right anterior cranial fossa, arising from the right orbital lamina of frontal bone. A fifteen-year-old boy was admitted because of a recent history of the right exophthalmus and headache. Neurological examination was essentially negative except papilledema in the both optic fundi and the right olfactory disturbance. Skull plain x-ray films showed the bony destruction of the right supraorbital bone and the some of abnormal calcification in the right anterior cranial fossa. CT scan showed cystic low density spots surrounded by irregular ring-like high density areas in the right anterior cranial fossa. Operation was performed on two stages and the tumor was removed totally. The tumor was arising from the orbital lamina of the frontal bone. The size of resected tumor was 7x5x4 cm. The pathological examination confirmed the diagnosis of chondromyxoid fibroma. Postoperatively, the patient is fully schooling without any disturbance 2 years and 7 months after the discharge. In Japan, two cases of intracranial chondromyxoid fibroma have been reported in literature. The authors discussed the histology of chondromyxoid fibroma and the genesis of the membraneous bone origin of the intracranial chondromatous tumor.

Adolescent↗
PubMed1982

[Problems on recurrence after removal of teratoma in pineal region--an experience of recurrence of pineal teratoma 4 years after tumor removal].

A case of teratoma in the pineal region which recurred 4 years after the first tumor removal was reported in this paper. When the patient was 5 years old, she, complained of headache and vomiting, and visited our hospital. As a heterogeneous mass with no enhancement effect was found in the pineal region by CT scan, she was admitted on November 9, 1976. There was no abnormalities on physical examination but neurological examination revealed slight disturbance of conjugate upward gaze (Parinaud's sign). Left vertebral angiogram demonstrated posterior superior displacement of posterior choroidal artery and downward displacement of Rosenthal vein, but early venous filling and tumor stain were not seen. Under preoperative diagnosis of a teratoma in the pineal region, the first operation (left occipital craniotomy and total removal of the tumor) was performed on November 24, 1975. Microscopic examinations revealed that the removed tumor was a mature teratoma in the pineal region. Postoperative course was uneventful and discharged on December 20, 1975. The follow-up study was continued at outside clinic after discharge. There was no signs of recurrence until 3 years after the first operation, but on January, 1981 (4 years after the first operation), she suffered from severe headache and vomiting again and re-admitted to our hospital on February 3, 1981. There was no remarkable neurological deficits except for the mild intracranial hypertensive sign and no changes of findings on angiogram. But CT findings were markedly characteristic. It revealed a heterogenous mass with remarkable enhancement effect in the pineal region and ventricular enlargement. Because a mixed type (teratomatous and germinomatous) of pineal tumors was suspected from the CT findings, irradiation was done after V-P shunt. The tumor was reduced to half size after the first course of 2000 rads irradiation, but there is no more reduction of the size of the tumor following the second course of 2000 rads (total 4000 rads) irradiation. Against the residual tumor, tumor removal was performed on June 2, 1981. Microscopically, the most part of the resected tumor showed fibrous changes caused by irradiation and partially teratomatous compartment. From this result (radiosensitivity and histology) the authors assumed that the recurred tumor could be a mixed type (germinoma and teratoma) of pineal tumor. Postoperative course was uneventful except for a transient disturbance of conjugate upward gaze and she was discharged on June 25, 1981. And now, there is no signs of recurrence 12 months after the second operation. Conclusively, it will be stressed that we should continue follow-up study the case even after total removal of teratoma, especially in the pineal region. Moreover, it was considered that there is a possibility of the changes of the histological features on recurrence of the pineal teratoma. When germinomatous compartment is suspected, irradiation is the first choice and then microsurgical operation should be done against residual tumor.

Brain Neoplasms↗
PubMed1981

Investigations on epileptogenic lesions in relation between ages of the patients and seizure manifestation.

The purpose of this report is to extract the age factor from multiple contributing factors to seizure manifestations in 357 cases of the various intracranial lesions, of which the locations and the pathological types had already been proven. The age distribution of the intracranial lesions depended largely upon their biological properties. Nevertheless, it had been proven that the seizure manifestation differed by ages of the patients even in the identical lesions. The younger patients were apt to lapse into seizures which became more frequent than in the older patients. The types of seizures seemed to be converted from the generalized to the partial, as the patients go through a transition from childhood to adulthood. Recognition of such a seizure manifestation is especially important in order to detect as soon as possible epileptogenic lesions as a surgically treatable cause of chronic epilepsy.

Adolescent↗