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Biomedical subjects

T Mikó

Publications and source records attributed to T Mikó.

16 recordsLinked to original sources
PubMed2001

[Multidisciplinary therapy of colorectal cancer].

A multidisciplinary program for the treatment of colorectal cancer is described. The main objective of the authors has been to define uniform up to date guidelines based on recent progress in the treatment of colorectal cancer. Preoperative diagnostic procedures are summarized which advance determination of clinical stage and prognosis. These information essentially determine care. Sequences of surgical methods, preoperative and postoperative radiotherapy and medical treatments are discussed according to tumor stages. Guidelines for surveillance following active treatment and recommendation for the screening of population at high risk for colorectal cancer are presented.

Algorithms↗
PubMed1999

45T-1, an established cell line with characteristics of Sertoli cells, forms organized aggregates in vitro after exposure to tumor necrosis factor alpha.

In the testis TNF is produced by germinal cells. The putative role of tumor necrosis factor alpha (TNF) in development and differentiation was investigated in 45T-1 mouse cell cultures, a cell line with characteristic markers of Sertoli cells, established from transgenic mouse families expressing the polyoma large T antigen in their testes. Exposure to TNF elicited a gradual assembly of the cells of the monolayer into highly organized spheroids. The first morphological sign of the changes was detected one week after TNF treatment by anti-desmin immunostaining which showed the formation of foci in the culture consisting of several hundred cells connected by an increasing number of cell contacts. Between days 10-20 the cells formed large ovoid or vermiform aggregates covered by several layers of flat, elongated cells. These cells extended septae into the inner mass of the spheroids consisting of loosely arranged, large polygonal or palisadic cells. The spheroids were surrounded by radially arranged elongated cells covered by small blebs. TNF treatment upregulated laminin expression in 45T-1 cell cultures, which is known to induce formation of cord-like structures by Sertoli cells in vitro. Coculturing 45T-1 cells with immortalized germinal cells or TNF-producing HeLa cells also lead to the formation of spheroids. These observations suggest that TNF production of germinal cells might contribute to the organization/differentiation of Sertoli cells.

Animals↗
PubMed1994

Clinical meaning of DNA content in the long term behaviour of follicular thyroid tumours: a 12-year follow up.

OBJECTIVE: To find out if there was any correlation between the DNA aneuploidy in benign tumours and in malignant follicular tumours of the thyroid and the progression of either disease. DESIGN: Retrospective study. SETTING: University hospital. SUBJECTS: 71 of 75 patients who had had cytofluorimetric nuclear DNA analyses done on their follicular thyroid tumours during the period 1977-1980, and for whom clinical follow up data were available. MAIN OUTCOME MEASURES: Correlation between clinical course and finding of aneuploidy in original histological specimens. RESULTS: Aneuploidy was found in 6/40 follicular adenomas, 3/17 adenomatous goitres, and in 13/14 follicular carcinomas. The patients were examined after 12 years, when there had been no recurrences of the benign tumours. 5 of the patients with carcinoma had died of distant metastases, all of whom had aneuploid stemlines. There are, however, 8 patients with carcinomas and aneuploidy who are still alive with no recurrences or metastases. CONCLUSIONS: DNA aneuploidy indicates neither the invasiveness nor the metastatic potential of follicular thyroid tumours, and does not distinguish between the minimally invasive (encapsulated) and highly invasive carcinomas.

Adenocarcinoma, Follicular↗
PubMed1990

[Fatal thrombotic microangiopathy in the mother and fetus].

The appearance of thrombotic microangiopathy (thrombotic thrombocytopenic purpura, haemolytic uraemic syndrome) could have been documented in a 23 years old pregnant woman, who had been treated previously for immune-thrombocytolytic purpura. The disturbing anamnestic data caused significant delay in correct diagnosis and in starting of fresh-frozen plasma therapy, so the woman and her fetus (in utero) had been died. The specific histological microangiopathic lesions could have been well documented by the autopsy of the mother, however no such alterations could have been detected in the fetus and placenta. This latter intriguing observation might be remarkable in the evaluation of several concepts dealing with the aetiopathogenesis of thrombotic microangiopathy. The short review of literature of thrombotic microangiopathy in pregnancy and puerperial period is also given.

Female↗
PubMed1990

Partial splenectomy performed by a special technique in dogs.

Closure of the splenic surface is solved at splenectomy by placing a raw of sutures using a double thread inserted at the same level by two straight needles. This technique does not require interpositions with a good haemostasis and so favours wound healing. It does not need many instruments and is easy to perform.

Animals↗
PubMed1982

Multiple arterial caliber persistence resulting in hematomas and fatal rupture of the gastric wall.

Caliber-persistent arteries come close to inner or outer body surfaces without ramification and reduction of their caliber. This abnormality may result in a variety of pathologic consequences. Their presence in the wall of the stomach or jejunum may eventuate in lethal hemorrhage. The causative role of this anomaly has also been clarified in the development of chronic ulcers of the lower lip. The first case of multiple occurrence of caliber-persistent arteries in the stomach is reported. The lethal outcome resulted from the rupture of the gastric wall.

Aged↗
PubMed1981

The juxtaoral organ-a pitfall for pathologists.

The first well-documented case in which the juxtaoral organ was identified in a surgical specimen removed because of oral cancer is reported. Recognition of this normal structure, the histological picture of which considerably resembles that of a mucoepidermoid carcinoma was crucial in determining the precise extent of the malignant process. Misinterpreting the JOO as cancer may lead to false prognoses or to unnecessarily extensive surgery. The differential diagnostic importance of orofacial epithelial structures localised perineurally is discussed.

Carcinoma↗
PubMed1980

Simulated cancer of the lower lip attributed to a "caliber persistent" artery.

Observations are reported on three lesions of the lower lip simulating cancer in elderly men and attributed to caliber persistent arteries. Persistent caliber arteries are those with a diameter larger than normal near a mucosal or external surface. Caliber persistency of the lip artery is best characterized by a quotient, using the distance from the border between epithelium and connective tissue as numerator, and its diameter as denominator. A quotient lower than 1.6 to 1.7 may be regarded as indicative of this vascular anomaly.

Adult↗