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Biomedical subjects

T Mikulski

Publications and source records attributed to T Mikulski.

At least 19 recordsLinked to original sources
PubMed2006

Effect of adrenergic blockade on plasma adrenomedullin concentration during static handgrip in patients with heart failure.

Our previous study showed that static handgrip caused increases in the plasma adrenomedullin (ADM) both in patients with heart failure (HF) and healthy subjects. The present study was designed to determine the role of the sympathetic nervous system in mediating plasma ADM changes during handgrip in patients with HF. Twelve male HF patients (II class NYHA) treated with carvedilol, a non-selective adrenergic blocker (TC) and 12 patients untreated with carvedilol (UC) performed two 3-min bouts of static handgrip at 30% of maximal voluntary contraction, alternately with each hand. At the end of both exercise bouts and in 5 min of the recovery period, plasma ADM and catecholamines were determined. In addition, heart rate, blood pressure and stroke volume (SV) were measured. The baseline plasma ADM, noradrenaline (NA) and adrenaline (A) levels were similar in the two groups of patients, while SV was higher (P<0.05) in TC than in UC. During exercise plasma ADM concentrations were lower (P<0.05) in TC than in UC, but the handgrip-induced increases in plasma ADM did not differ between the groups. Plasma ADM correlated with NA concentrations (r = 0.764) and with SV (r = -0.435) and increases in plasma ADM expressed as percentage of baseline values correlated with those of plasma NA (r = 0.499), diastolic BP (r = 0.550) and total peripheral resistance (r = 0.435). The study suggests that the sympathetic nervous system may be involved in the stimulation of ADM secretion during static exercise either directly or by changes in the haemodynamic response.

Adrenergic beta-Antagonists↗
PubMed2006

Effect of 6-week endurance training on hemodynamic and neurohormonal responses to lower body negative pressure (LBNP) in healthy young men.

Endurance training is considered as a factor impairing orthostatic tolerance although an improvement and lack of effect have been also reported. The mechanisms of the changes and their relation to initial tolerance of orthostasis are not clear. In the present study, effect of moderate running training on hemodynamic and neurohormonal changes during LBNP, a laboratory test simulating orthostasis, was investigated in subjects with high (HT) and low (LT) tolerance of LBNP. Twenty four male, healthy subjects were submitted to graded LBNP (-15, -30 and -50 mmHg) before and after training. During each test heart rate (HR), stroke volume (SV) and blood pressure, plasma catecholamines, ACTH, adrenomedullin, atrial natriuretic peptide, and renin activity were determined. Basing on initial test, 13 subjects who withstood LBNP at -50 mmHg for 10 min were allocated into HT group and 11 subjects who earlier showed presyncopal symptoms to LT group. Training improved LBNP tolerance in six LT subjects. This was associated with attenuated rate of HR increase and SV decline (before training, at -30 mmHg deltaHR was 21 +/- 4 beats/min and deltaSV - -36+/- 8 ml while after training the respective values were 8 +/- 4 beats/min and -11+/- 6 ml). No differences in hemodynamic response were found in HT subjects and those from LT group whose LBNP tolerance was unchanged. In neither group training affected neurohormonal changes except inhibition of plasma ACTH rise in subjects with improvement of LBNP tolerance. It is concluded that some subjects with low orthostatic tolerance may benefit from moderate training due to improvement of cardiac function regulation.

Adrenocorticotropic Hormone↗
PubMed2006

Effect of prolonged dynamic exercise on plasma adrenomedullin concentration in healthy young men.

The aim of the study was to find out whether prolonged exercise influences plasma adrenomedullin (ADM) concentration and whether it is related to the hormonal, metabolic and cardiovascular changes. Eighteen healthy subjects (age 25+/-1 yrs) were submitted to cycle exercise for 90 min at 70% of maximal oxygen uptake. Heart rate (HR) and blood pressure (BP) were measured continously. Before, at 30(th) min, and at the end of exercise venous blood samples were taken for [ADM], noradrenaline [NA], adrenaline [A], atrial natriuretic peptide [ANP], plasma renin activity PRA, interleukin-6 [IL-6] and lactate [LA] determination. Significant increases in plasma ADM and IL-6 were found at 90(th) min whereas other hormones were elevated already at 30(th) min of exercise. Positive correlations were ascertained between [ADM] and [NA] (r=0.47), [ANP] (r=0.35) or [IL-6] (r=0.35) and between exercise-induced increases in [ADM] and [NA] (r=0.38). PRA correlated positively with [NA] and [ANP]. Negative correlation was found between plasma [ADM] and diastolic BP. The present data suggest that increase in sympathetic nervous activity and cytokine induction during prolonged exercise may be involved in plasma ADM release and that increase in ADM and ANP secretion may be a compensatory mechanism against further elevation of blood pressure.

Adrenomedullin↗
PubMed2005

Exercise training and 3-day head down bed rest deconditioning: exercise thermoregulation.

UNLABELLED: Bed rest (BR) deconditioning causes excessive increase of exercise core body tempera-ture, while aerobic training improves exercise thermoregulation. The study was designed to determine whether 3 days of 6 degrees head-down bed rest (HDBR) affects body temperature and sweating dynamics during exercise and, if so, whether endurance training before HDBR modifies these responses. Twelve healthy men (20.7+/-0.9 yrs, VO2max: 46+/-4 ml x kg(-1) x min(-1) ) underwent HDBR twice: before and after 6 weeks of endurance training. Before and after HDBR, the subjects performed 45 min sitting cycle exercise at the same workload equal to 60% of VO2max determined before training. During exercise the VO2, HR, tympanic (Ttymp) and skin (Tsk) temperatures were recorded; sweating dynamics was assayed from a ventilated capsule on chest. Training increased VO2max by 12.1% (p<0.001). Resting Ttymp increased only after first HDBR (by 0.22 +/- 0.08 degrees C, p<0.05), while exercise equilibrium levels of Ttymp were increased (p<0.05) by 0.21 +/- 0.07 and 0.26 +/- 0.08 degrees C after first and second HDBR, respectively. Exercise mean Tsk tended to be lower after both HDBR periods. Total sweat loss and time-course of sweating responses were similar in all exercise tests. The sweating threshold related to Ttymp was elevated (p<0.05) only after first HDBR. IN CONCLUSION: six-week training regimen prevents HDBR-induced elevation of core temperature (Ttymp) at rest but not during ex-ercise. The post-HDBR increases of Ttymp without changes in sweating rate and the tendency for lower Tsk suggest an early (<3d) influence of BR on skin blood flow.

Adult↗
PubMed2005

Hemodynamic and neuroendocrine predictors of lower body negative pressure (LBNP) intolerance in healthy young men.

Exposure to LBNP results in body fluid shift to lower extremities similarly as under influence of orthostatic stress. In susceptible persons it leads to syncope. For better understanding why certain individuals are more susceptible to orthostatic challenges it seemed necessary to collect more data on hemodynamic and neuroendocrine adjustments occurring before onset of presyncopal symptoms Accordingly, in this study heart rate (HR), blood pressure (BP), stroke volume (SV), cardiac output (CO), hematocrit, plasma catecholamines, adrenomedullin, ACTH and plasma renin activity (PRA) were measured in 24 healthy men during graded LBNP (-15, -30 and -50 mmHg). Thirteen subjects completed the test (HT group) whereas 11 had presyncope signs or symptoms at -30 mmHg or at the beginning of -50 mmHg (LT group). Comparison of these groups showed that LT subjects had lower baseline total peripheral resistance and higher plasma adrenomedullin. During LBNP plasma catecholamine and PRA increases were even greater in LT than in HT group while plasma adrenomedullin elevations were similar in both groups. Plasma ACTH increased only in LT group following presyncope symptoms. Low tolerant group showed more rapid decline of SV and CO than HT subjects from the beginning of LBNP. It is suggested that measurements of SV at the level of LBNP which did not evoke any adverse symptoms may be of predictive value for lower orthostatic tolerance.

Adrenocorticotropic Hormone↗
PubMed2003

Plasma adrenomedullin response to maximal exercise in healthy subjects.

The aim of the study was to find out whether maximal exercise performed by healthy young men influences plasma adrenomedullin concentration (ADM) and is the peptide level related to the cardiovascular, metabolic and hormonal changes induced by exercise. Ten subjects (age 24+/-1.0 yr) participated in the study. They performed graded bicycle ergometer exercise until exhaustion. Heart rate (HR) and blood pressure (BP) were measured throughout the test. Before and at the end of exercise venous blood samples were taken for [ADM], noradrenaline [NA], adrenaline [A], growth hormone [hGH], cortisol and lactate [LA] determination. Plasma [ADM] decreased during exercise from 1.71+/-0.09 to 1.53+/-0.10 pmol x l(-1) (p<0.01). This was accompanied by increases in plasma catecholamines and [hGH], while plasma cortisol level did not change. Positive correlation was found between the exercise-induced decreases in plasma ADM and diastolic BP. Blood [LA], systolic and mean BP at the end of exercise correlated negatively with plasma [ADM]. No significant interrelationships were found between plasma ADM, catecholamines or the other hormones measured. The present data suggests, that maximal exercise inhibits ADM secretion in young healthy men. Metabolic acidosis and a decrease in peripheral resistance might be involved in this effect.

Adrenomedullin↗
PubMed2000

[Concentration of serum vitamin C in workers exposed to selected physical and chemical risk factors].

Determination of the serum vitamin C levels may yield the information on the nutritional status of workers. Increasing community awareness of the health-enhancing nutrition patterns as an element of the promotion of lifestyles conducive to health among workers may limit a negative impact of risk factors on workers' health. The aim of this study was to analyse the levels of serum vitamin C in workers exposed to selected physical (noise, electromagnetic fields) and chemical risk factors present in the work environment. Two randomised groups of male workers, one exposed to physical factors (n = 43; mean age 39.5 +/- 8.6 yr.), and the other to chemical factors (n = 40; mean age 38.3 +/- 8.0 yr.) were included in the study. The control group was composed of male workers (n = 36; mean age 40.4 +/- 10.1 yr.) exposed neither to physical nor to chemical factors. In all subjects, the serum vitamin C levels were measured using the spectrophotometric method by Kyaw. The mean serum vitamin C levels in the workers exposed to physical and chemical factors were 30.1 (mumol/l) and 30.9 (mumol/l), respectively, and their statistical significance was lower (p < 0.01) as compared with the mean serum vitamin C levels of 39.7 (mumol/l) in the control group.

Adult↗
PubMed1997

[Analysis of occupational accidents in the years 1982-1994 in the Szczecin Province].

The aim of the study was to analyse the incidence of accidents at work in the Szczecin voivodship in 1982-94. In the analysis the number of workers employed in the national economy and the number of accidents were taken into account. The rate of accidents at work (the number of accidents/1,000 workers in /1000), the accident severity (the number of work disability days/the number of accidents at work), the rate of fatal accidents at work (the number of fatal accidents/1,000 workers in /1000), the rate of acute injuries (the number of severe injuries per 1,000 accidents at work) were determined. The rates of accidents at work and fatal accidents in the Szczecin voivodship were compared with the rates in the whole country during the same period. The number of workers employed throughout the period between 1982-94 maintained at almost the same level. It increased mostly in 1990 and then decreased (Table 1). The largest number of accidents was registered in 1983 and the lowest in 1994. During the period studied the number of fatal accidents and absenteeism due to accidents at work decreased, however, the rates of fatal accidents and acute injuries increased. The rate of accidents at work in the Szczecin voivodship during the years 1982-94 was higher than in the whole country.

Absenteeism↗
PubMed1994

[Noise level in Szczecin schools and selected health indicators of students].

There was an examination made in thirty schools chosen at random in Szczecin as for the level of indoor and outdoor noise. In two-thirds of the schools noise was found out to exceed the accepted limit. There was larger number of children with hearing deficiencies and/or psychic disturbances in those schools. The conclusion of the investigation can be drawn that one of the causes of transgression of indoor noise limit in newly built schools is the use of building materials of low insulating power. Additionally green areas should be set up and acoustic screens in order to separate schools in the centre of the city which are exposed to a high level of outdoor noise.

Adolescent↗
PubMed1994

Assessment of the respiratory system in workers occupationally exposed to phosphorite and apatite dusts.

The respiratory system in 118 male workers occupationally exposed to phosphorite and apatite dusts was assessed. Subjective, physical and spirographic examinations were performed and chest X-ray pictures were taken. No significant differences between the exposed workers and the control group were found. There was only a statistically significant decrease in spirometric parameters in the exposed group in comparison with controls. There was no such relationship in regard to the length of employment and smoking habit. In the exposed group there were no significant disturbances of the lung ventilation efficiency.

Adult↗
PubMed1994

Hemolytic activity of phosphorite and apatite dusts in vitro.

An examination was performed to assess the hemolytic activity of phosphorite and apatite dust in vitro by a method used by Potts et al. (1978). After evaluation of dispersion, a certain contents of elements was established, using a spectrometer of X-ray fluorescence. Phosphorite dusts caused 50.4% of hemolyse that is about 5 times more than those caused by dust of apatites. The mean hemolysis index for phosphorite dust was 0.799 and for apatite dust 0.142. Thus, phosphorites are much more toxic to a human being than apatites. A higher level of hemolytical activity in phosphorite dust as compared to apatite one can be explained by significant difference in the contents of certain elements, SiO2, in particular. The mean SiO2 level in samples containing phosphorites was 6.3 +/- 0.1% compared to samples of apatites (3.8 +/- 0.09%).

Apatites↗
PubMed1993

Assessment of the nasal mucosa in workers exposed to the prolonged effect of phosphorite and apatite dusts.

One hundred and thirty one workers occupationally exposed to phosphorite and apatite dusts and a control group underwent repeated laryngological and cytological examinations of nasal mucosa smears. The clinical examination showed chronic simple or atrophic rhinitis. The cytological test revealed metaplasia of the respiratory epithelium towards squamous epithelium in all smears. Both the rate of catarrhal changes and the degree of epithelial metaplasia varied with the duration of exposure.

Adult↗
PubMed1978

[Dynamics of changes in rat osseous system in chronic cadmium poisoning].

The rats were given subcutaneously CdSO4 in doses 0.7 mg/kg of body weight once a week during one year. After the lapse of 6, 9 and 12 months, the animals were sacrificed and their blood was used to determine the preselected biochemical indices (erythrocytes, hemoglobin, hematocrit, levels of protein, albumins, globulins GOT, GPT, AP and its isoenzymes, calcium, inorganic phosphorus, urea and creatinines). Simultaneously radiological examinations were performed on prepared and dehydrated long bones being estimated. Changes were revealed in morphological parameters of long bones with a marked demineralisation of epiphyses after 9 months of investigations. The above changes were found to correlate with those referring to biochemical indices levels, intensifying with the increase of the exposure period.

Alkaline Phosphatase↗
PubMed1977

[Effect of chronic action of cadmium sulfate on various biochemical indices of blood serum and on the histological picture of rat liver and kidneys].

Male rats weighing 180-220 g were given CdSO4, 0,4 mg/kg body weight subcutaneously once a week for 6-12 months. The animals were killed after 6, 9, 12 months and following blood serum levels were determined: total protein, albumin, globulin, GPT, GOT, Al.P. and urea. The tissue tissue samples from liver and kidneys were examined histologically (acid and alkaline phosphatase). After 9 months, the difference between values of biochemical indices in the exposed and control groups was statistically significant. It has been found that the observed biochemical indices show correlation with the extent of morphological changes in liver and kidneys. These degenerative changes became more intense in the liver than in the kidneys.

Animals↗