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Biomedical subjects

T Moalem

Publications and source records attributed to T Moalem.

6 recordsLinked to original sources
PubMed1983

The prevalence of antibodies to histones induced by procainamide in old people, in cancer patients, and in rheumatoid-like disease.

Antibodies to histones were found to be most commonly responsible for the positive antinuclear antibody (ANA) test in asymptomatic patients treated with procainamide, in old people, in patients with neoplastic diseases, and in young women affected with a rheumatoid-like disease. Only in a very few patients were antibodies to dDNA and nucleoproteins demonstrated. Antibodies to nDNA were not found. The antibodies to histones were demonstrated by two methods: absorption of ANA-positive sera with a histone solution and subsequent performance of an ANA test; and acid elution of histones from thyroid sections followed by histone reconstitution.

Adolescent↗
PubMed1981

Deposits of immunoglobulins and C3 in the walls of human renal arteries.

Ninety-one renal biopsies were examined by immunofluorescent staining for the presence of C3 and immunoglobulins in the walls of renal arteries (RAW), tubules and glomeruli. The diseases studied were non-systemic renal immune complex diseases, systemic diseases with kidney involvement, renal diseases with minimal pathological changes and histological normal kidneys. In a high percentage of cases C3 and, to a lesser degree, deposits of immunoglobulins were found in the RAW, the deposits being found both in immunological and non-immunological diseases. Deposits of C3 but not of C4, C1q, fibrinogen, and immunoglobulins were found in the RAW of 11 normal kidneys examined.

Diabetic Nephropathies↗
PubMed1980

Cholestatic jaundice: an immune response to prajmalium bitartrate.

Cholestatic jaundice associated with chills, pruritus and blood eosinophilia developed in a patient who received prajmalium bitartrate therapy for ventricular arrhythmia following acute myocardial infarction. Discontinuation of the drug resulted in a spontaneous improvement in the clinical and biochemical findings. Challenge by prajmalium bitartrate caused rapid reappearance of the clinical and biochemical features. In immunological studies, deposits of IgG and IgA were detected at the bile canaliculi by fluorescent staining, and the patient's lymphocytes produced macrophage migration inhibition after in vitro incubation with prajmalium bitartrate. Thus, laboratory results support the assumption of an allergic mechanism.

Ajmaline↗
PubMed1980

Circulating immune complexes in children with acute poststreptococcal glomerulonephritis.

Sera from 22 children with acute poststreptococcal glomerulonephritis were examined for circulating immune complexes (CIC) during the acute phase of the disease and six to eight months following its onset. CIC were found in 10 of 22 (45%) children during the acute phase and in 4 of 19 (21%) during follow-up. No correlation was found between the presence of CIC during the acute phase and disease severity as measured by several clinical and laboratory parameters. There was, however, a positive correlation between the presence of CIC in serum and the duration of proteinuria following disease onset. The possible role of CIC in the induction of chronic glomerulonephritis following acute poststreptococcal glomerulonephritis is discussed.

Acute Disease↗