Biomedical subjects

T Moon

Publications and source records attributed to T Moon.

21 records · Page 2Linked to original sources

PubMedDate not supplied

Hypoplastic acute leukemia: review of 70 cases with multivariate regression analysis.

Between 1971 and 1984, 22 of 190 adult patients (11.6 per cent) with acute leukemia seen at the University of Arizona had hypocellular acute leukemia (HAL), defined as lymphoblasts or myeloblasts (plus atypical promyelocytes) of greater than or equal to 30 per cent, but marrow cellularity of the core biopsy or clot section of less than or equal to 50 per cent based on a 1000 point count. These 22 patients with HAL plus the 48 previously published patients with well documented HAL (combined series of 70 patients) were evaluated in detail with multivariate analysis. The median leukocyte count was 2700/microL, hemoglobin of 8.2 g/dl, and platelet count 63,000/microL. Circulating blasts were noted in 27 of 52 patients (52 per cent). Twenty-seven of 34 patients (79 per cent) had abnormal cytogenetics. The overall median survival was 8 months (range: 0.1-48). The median survival for the 22 patients managed with supportive care alone was 4 months, 6 months for the 16 patients treated with non-aggressive induction therapy, and 13 months for the 32 patients treated with aggressive induction therapy (p less than 0.02 versus other categories). Multivariate analysis confirmed that aggressive induction therapy was a major favourable prognostic factor (p = 0.016). Multivariate analysis of the aggressively induced patients revealed that younger patients (less than or equal to 65; p = 0.04) and patients with no AHD (p = 0.09) lived longer. Thus, aggressive remission induction can be attempted in HAL and appears to contribute to prolonged survival especially under age 65 years.

Acute Disease↗

PubMedDate not supplied

New approach to radial expansive force measurement of self expandable esophageal metal stents.

The accurate measurement of radial expansive force is crucial for optimal design and implantation of self expandable esophageal metal stents. In the present study, a new method of measurement under experimental conditions simulating actual stent implantation has been developed. This method offers precise and reproducible measurements and can be applied to a wide variety of stent types. In particular, the method enables one to measure expansive pressure as well as the true radial expansive force up to the radial compression ratio of 72%, covering the range of compression often encountered in a partially obstructed lumen. The test results for various kinds of metal stents are presented and compared. Based on these results, three important points of observation critical in explaining and predicting the expansion characteristics of stents have been reported. Further understanding and characterization of these findings will be necessary for developing new stents with outstanding clinical efficacy.

Compliance↗

PubMedDate not supplied

Micronutrient concentrations in paired skin and plasma of patients with actinic keratoses: effect of prolonged retinol supplementation.

Much of our knowledge about the relationship between micronutrients and cancer comes from studies in which plasma (serum) micronutrient levels have been correlated with cancer incidence; however, the relationship between the concentrations of micronutrients in the plasma and in the target tissues has not been established. Ninety-three subjects (62 males and 31 females ages 42-86, median age 69) with actinic keratoses were recruited for investigation of this relationship. The subjects were randomly assigned and received placebo or retinol (25,000 IU/day) intervention for 48 to 65 months as part of a skin cancer chemoprevention trial. Shortly before the end of the trial, three fasting plasma samples and one skin biopsy were obtained from each subject. The concentrations of lutein, zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, beta-carotene, cis-beta-carotene, retinol, retinyl palmitate, alpha-tocopherol and gamma-tocopherol in the plasma and skin were simultaneously measured using HPLC. The profiles of the eleven micronutrients in the plasma and skin were similar. Lycopene, beta-carotene and alpha-tocopherol were the predominant micronutrients in both plasma and skin, but the ratio of retinyl palmitate to retinol was much greater in the skin than plasma. The three fasting plasma concentrations from the same subject during a one-month period were very consistent; however, the between-person variations were very large. The retinol supplementation caused a significant increase in the plasma concentrations of retinol, retinyl palmitate, lutein and alpha-tocopherol, especially retinyl palmitate as well as the skin concentrations of retinol and retinyl palmitate.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗