PubMed Health⌕ Search

Biomedical subjects

T Mork

Publications and source records attributed to T Mork.

At least 19 recordsLinked to original sources
PubMed1993

Mechanisms of nonopsonic phagocytosis of Pseudomonas aeruginosa.

The interaction of the macrophage cell line P388D1 with Pseudomonas aeruginosa in the absence of stimulators or opsonins led to substantial association of bacteria, as judged by visual counting and FACScan assays. This association was observable within 5 min of addition of bacteria, could not be disturbed by exhaustive washing, and occurred with pilus- or flagellum-deficient mutants but not with rpoN mutants, which have been proposed to lack a secondary adhesin. In contrast, specific antibody was capable of causing similar enhancement of bacterial uptake regardless of the rpoN phenotype. Fibronectin stimulated uptake of bacteria with the pilus as an adhesin, and stimulation was observable within 5 min. Both fibronectin-enhanced and antibody-opsonized uptake were susceptible to inhibition by pertussis toxin but not by cholera toxin. The influence of fibronectin on P388D1 cells was distinguishable from that of lipopolysaccharide, which caused substantial morphological changes in cells. Although lipopolysaccharide stimulated bacterial uptake, it actually suppressed fibronectin-mediated enhancement of uptake at high concentrations.

Adhesins, Bacterial↗
PubMed1992

[Complaints of patients on medical treatment].

Complaints handled by the Directorate of Health about medical treatment have been registered and analysed for the years 1980, 1985 and 1990. The analysis shows that the number of complaints against government hospitals increased fourfold from 1985 to 1990. Compensation awarded in cases where medical negligence was proved rose sevenfold from NOK 3 million in 1985 to NOK 20 million in 1990. We have reason to believe that there has been a similar increase in the number of claims for compensation, and in the amount of compensation awarded in cases of proven negligence, also in cases not involving the Directorate of Health. It is important to note that our study demonstrates an increase in serious events leading to permanent functional impairment or death. A post hoc analysis suggests that some 80% of the failures might have been avoided if an adequate system of quality assurance had been established.

Humans↗
PubMed1991

[Quality assurance in Norwegian somatic hospitals].

In 1990, 70 Norwegian hospitals were mailed a questionnaire asking about quality assurance (QA) activities in the departments of internal medicine, surgery, gynaecology/obstetrics and pediatrics. Responses from 173 departments at 58 hospitals showed a marked interest in improving quality and quality assurance. However, few departments had implemented QA to any noticeable extent in their clinical practices. There were few differences between surgical and non-surgical departments. Only 30% of the respondents had established routines aimed at ensuring complete medical records. 47% had not established committees to record and evaluate accidents, or report hazards to patients, in spite of the fact that only 5% assumed QA was of little usefulness. In 1990, little time was spent on specific QA activities; the most common estimate was one hour per week. In our estimate, full QA in clinical department would require 2-5% of the total contribution of work.

Hospital Departments↗
PubMed1991

[Small hospitals--future tasks and functions].

We review the small municipal hospitals included in our study of hospitals serving less than 50,000 persons. We identified the following problems: These hospitals are resource-intensive to a greater degree than expected, measured in terms of beds, doctors, health services and per capita costs in the area served by the hospital. Moreover, their quality is questionable, due to problems of recruitment and lack of continuity, a weak infrastructure, and insufficient patients to maintain a high level of competence, especially in taking care of patients with complicated and acute conditions. We foresee, and recommend, a new and different future for small hospitals, emphasizing closer links with primary health care and closer collaboration with the larger county hospitals. Key words are: Outpatient services, including perhaps ambulatory specialist services from the larger hospitals, elective services in fields of special competence, possibly covering a larger area, rehabilitation services, municipal psychiatric services; and finally, the traditional acute services should be changed to a first-aid service, preferably as part of emergency care in the municipality.

Hospitals, Municipal↗
PubMed1991

[Alcohol and drug problems in the Third World].

The paper reviews recent development in abuse of alcohol, narcotics and psychotropic substances in developing countries. There has been a marked increase in production and sale of alcoholic beverages, and alcohol abuse has spread to new groups of the population. This has led to serious social and health problems in many developing countries. There has also been a substantial increase in abuse of narcotic drugs and psychotropic substances in some developing countries. The illicit production and traffic in narcotic drugs have resulted in more crime and corruption, and in some countries to terrorism and economic and political destabilization. The paper also summarizes activities undertaken within the UN-system in the field of alcohol and drug abuse.

Alcohol Drinking↗