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Biomedical subjects

T Munkner

Publications and source records attributed to T Munkner.

11 recordsLinked to original sources
PubMed1986

Regional V/Q changes in asthmatics after histamine inhalation.

The immediate changes in regional ventilation and pulmonary blood flow were studied in seventeen adults with perennial asthma and in two control persons, who were challenged by histamine inhalation (histamine induced asthma (HIA)). The studies were based on gammacamera images of 81mKr and of 99mTc labelled particles in the lungs and the results were compared with simultaneous changes in peak expiratory flow (PEF). No changes were observed in normal persons. After histamine inhalation the ventilation pattern became patchy, but no changes were seen in the blood flow distribution. PEF was markedly reduced. On repeated challenges ventilatory changes after HIA did not result in stereotypic images. HIA-defects were dissimilar to exercise- and antigen-induced defects when studied in the same patient(s) and were different, too, from the result in the same patients during a spontaneous asthmatic attack. The therapeutic and prophylactic effects of terbutaline were demonstrated in patients exposed to a histamine challenge.

Adult↗
PubMed1986

Regional V/Q changes in asthmatics after antigen inhalation.

The immediate changes in regional ventilation and pulmonary blood flow were studied in five adults with perennial asthma, who were challenged with an allergen inhalation (pollen or moulds). The studies were based on gammacamera images of 81 mKr and of 99mTC labelled particles in the lungs and the results were compared with simultaneous changes in peak expiratory flow. Moderate to profound changes were observed after antigen-induced asthma (AIA), and ventilation and perfusion defects were matched in most regions. Peak expiratory flow was reduced in most of the cases after AIA.

Adolescent↗
PubMed1986

Regional V/Q changes in asthmatics after exercise.

The immediate changes in regional ventilation and pulmonary blood flow were studied in fifteen adults with perennial asthma and in two control persons, who were challenged by moderate exercise on a treadmill or bicycle ergometer. Ventilation was studied before and immediately after the exercise, and again about five min after stopping the provocation. Peak expiratory flow was checked at regular intervals. Five min after cessation of the exercise ventilation had become patchy and irregular, but the pulmonary blood flow distribution remained "normal", i.e. as seen in the resting state. The ventilatory defects could be prevented by pretreatment with terbutaline or eliminated by terbutaline treatment after development of signs and symptoms. From repeat studies it can be concluded that the development of regional ventilatory defects after EIA do not follow a stereotypic course nor are defects similar to those provoked by histamine or allergens.

Adolescent↗
PubMed1985

131I-meta-iodobenzylguanidine scintigraphy of neuroblastomas.

Sixteen neuroblastoma patients have been studied by 131I-meta-iodobenzylguanidine (MIBG) scintigraphy. Three patients were possibly cured, and their scintigraphy results were normal. Thirteen patients had tumors and metastases demonstrated by 131I-MIBG, two of these patients had a normal vanillylmandelic acid (VMA) excretion level. One patient has been treated by 131I-MIBG, but died. 131I-MIBG was concentrated in other cells too, eg, in erythrocytes and platelets.

3-Iodobenzylguanidine↗
PubMed1975

131I-19-iodocholesterol scintigraphy of the adrenal cortex.

131-I-19-iodocholesterol scintigraphy of the adrenal cortex has been carried out in 26 patients. In 4 patients with normal adrenocortical function the tracer was equally accumulated on the two sides. In 7 patients with untreated Cushing's syndrome, bilateral uptake was found in 4 patients with bilateral hyperplasia whereas unilateral visualization was obtained in three cases of cortisol producing adenomas. The side localization was confirmed at operation. Eight patients had been operated for Cushings syndrome prior to the scintigraphy. Remnant adrenocortical tissue with negligible or subnormal function (4 patients) could not be visualized. Normo- or hyperfunctioning remnant tissue was visualized in 3 patients. One patient had recurrent hypercorticism due to metastases from a previously removed adrenocortical carcinoma; a single pelvic accumulation was seen, whereas several metastases in the abdomen and thorax were not visualized. Four patients with aldosteronism were investigated. Three had primary aldosteronism due to an adrenocortical adenoma. In two of these, the site of the adrenal lesion was localized pre-operatively. In the third patient, equal bilateral accumulation of iodocholesterol was seen even after suppression with dexamethasone. At operation a small tumour was found. In 1 patient with indeterminate aldosteronism both glands were visualized and at a second examination the uptake was equally suppressed by dexamethasone.

Adrenal Cortex↗