PubMed Health⌕ Search

Biomedical subjects

T Murano

Publications and source records attributed to T Murano.

At least 37 records · Page 2Linked to original sources
PubMed1979

Antagonism by naloxone of tolerance and dependence in mice given a single dose of morphine.

The effect of naloxone given at various times after morphine administration on the development of tolerance to and dependence on a single dose of morphine was studied. Naloxone antagonized the analgesic effect of morphine and the development of tolerance to and dependence on morphine, dose dependently. The time course of the development of tolerance to a single dose of morphine almost paralleled that of dependence on morphine but the time course of the disappearance of tolerance did not coincide with that of dependence. When start of the duration of action of morphine was blocked by naloxone for various time intervals, the degree of tolerance to and dependence on morphine was antagonized, time dependently. When the end of the duration of action of morphine was antagonized by naloxone for various time intervals, tolerance and dependence which developed up to that time was completely antagonized by naloxone.

Analgesics↗
PubMed1978

Studies on the function of cell membrane. 11th Report: Binding of cytochrome b5 to liver microsomes and plasma membranes isolated from normal and CCl4-treated rats.

Cytochrome b5 was isolated from liver microsomes using a detergent-method. The hemoprotein was found to bind to liver plasma membranes in vitro and was accompanied by an increase in NADH-cytochrome c reductase activity, but not NADH-ferricyanide reductase activity. As in the case of microsomes, the binding to plasma membranes was temperature-dependent and was tight to the extent that the bound cytochrome b5 was little released under high ionic strength. The capacity of plasma membranes for the binding was less than that of microsomes. Administration of CCl4 did not significantly affect the binding of the hemoprotein in both fractions. These results add support to our previous proposal that the elevation of NADH-cytochrome c reductase activity of liver plasma membranes observed early after administration of CCl4 may be caused by the binding of cytochrome b5 which has probably migrated from the endoplasmic reticulum.

Animals↗
PubMed1978

Studies on the physical dependence potential of analgesics.

Influence of morphine on the fine structure of mitochondria in the cell of zona fasciculata of adrenal cortex in mice treated chronically with morphine pellets was studied using the electron microscope. The trnasformation of mitochondrial structure was observed 12 hours after morphine pellet implantation and the degree of transformation reached a maximum at 48 hours. These changes, however, disappeared within 4 days. On the 4th day after implantation, removal of the pellet or levallorphan challenge resulted in alteration of the mitochondria with evidence of withdrawal syndrome. Reinjection of morphine to the mice immediately after removal of the pellet, however, prevented the appearance of such mitochondrial transformation. Chlorpromazine or sodium pentobarbital did not affect on the transformation of mitochondria.

Adrenal Cortex↗
PubMed1976

Changes in some marker enzyme activities of liver plasma membranes during regeneration after partial hepatectomy in rats.

Liver plasma membranes were isolated from regenerating rat livers between 20 h and 10 days after partial hepatectomy in order to study the effect of partial hepatectomy on some membrane enzyme activities. Mg2+-ATPase (EC 3.6.1.4) activity, but not (Na+ + K+)-ATPase activity, decreased slightly at 2 days, whereas leucyl beta-naphthylamidase (EC3.4.1.1) and 5'-nucleotidase (EC3.1.3.5) activities increased considerably at 1-2 and 3-5 days, respectively. These changes were not parallel to a sharp increase in mitotic activity of liver cells which occurred at 36 h.

Adenosine Triphosphatases↗