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Biomedical subjects

T Muteki

Publications and source records attributed to T Muteki.

At least 37 records · Page 2Linked to original sources
PubMed1991

Chronic or intractable medical problems associated with prolonged exposure to unsuspected harmful environmental electric, magnetic or electro-magnetic fields radiating in the bedroom or workplace and their exacerbation by intake of harmful light and heavy metals from common sources.

Unsuspected prolonged exposure to abnormal environmental (very high frequency) electro-magnetic fields (EMF), electric fields (EF) or magnetic fields (MF) at 60 Hz or 16K Hz in the bedroom or workplace may contribute to the development of various intractable medical problems. Most of the clinical symptoms appear when the individuals are exposed to EMF for many hours a day for at least several months to 1-year for relatively benign diseases or symptoms (such as intractable pain or medical problems), or several to over 10 years for more serious diseases (such as cancers of the digestive system or other organs), all of which seem to appear with the additional co-existence of micro-circulatory disturbances with Thromboxane B2 (TXB2), bacterial or viral infections and decrease or absence of acetylcholine, and lead, mercury, or aluminum deposits, with or without asbestos. These abnormal environmental EMF's or EF's can be detected by the Bi-Digital O-Ring Test, which has good correlation with standard laboratory measurement, especially with EF measurement, and the distribution of EMF often includes a linear band-like appearance on the abnormal part of the patient's body, as well as on the patient's corresponding area of the bed, or at the workplace. These EMF's can be eliminated either by a metal sheet, acting as a reflector, which redirects the harmful EMF or eliminates it completely by grounding the metal sheet at high frequency range, while extremely low frequency (ELF) magnetic fields at the near field are more difficult to eliminate. Several examples of medical problems that appear to be associated with repeated and prolonged exposure to abnormal environmental EMF, EF or MF are summarized in this article. EF or MF-induced abnormalities were artificially and reversibly created in humans by exposing the extremities or head to a 10Volt/Meter (V/M) EF at 60 Hz about 33 (evening) to 50 cm (daytime or after midnight) from a pair of rubber insulated wires connected to an AC source, but where no current is passed, so that no extra MF exists. After exposing normal parts of the extremities and head to a 10 V/M EF for 5 minutes, abnormal increase of TXB2 and disappearance or significant reduction of acetylcholine was observed for 5 minutes, and slightly longer abnormal time duration was observed in those who have aluminum, lead, or mercury deposits. This indicates that the upper limit of relatively safe EF should be around 10V/M at 60 Hz rather than 25V/M at ELF by Swedish Government recommendation, which is now widely accepted.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗
PubMed1991

Is the diagnosis of significant residual neuromuscular blockade improved by using double-burst nerve stimulation?

This study evaluated the use of double-burst stimulation (DBS) in the diagnosis of significant post-operative residual neuromuscular blockade. Ninety patients were allocated to three equal groups. In Group A the degree of residual neuromuscular blockade was assessed by clinical criteria (CC) only; in Group B by CC and manual evaluation of the response to train-of-four (TOF) nerve stimulation; and in Group C by CC, manual evaluation of the response to TOF, and DBS stimulation. Immediately after arrival in the recovery room mechanical twitch was recorded using TOF stimulation. The mean (+/- SD) TOF ratios were 0.53 +/- 0.19 in Group A, 0.67 +/- 0.11 in Group B and 0.81 +/- 0.08 in Group C. The incidence of a TOF ratio of less than 0.7 was 83.3% in Group A, 56.7% in Group B and 6.7% in Group C. It is concluded that the use of DBS enabled the anaesthetist to recognize significant residual block and thus reduced the incidence of post-operative residual neuromuscular blockade.

Analysis of Variance↗
PubMed1990

Volatile anaesthetics inhibit a cyclic AMP-dependent sodium-potassium current in cultured sensory neurones of bullfrog.

1. Cultured dorsal root ganglion cells of the bullfrog were voltage-clamped in the whole-cell configuration. 2. An adenosine 3':5'-cyclic monophosphate (cyclic AMP)-dependent cationic inward rectifier (IH) was inhibited by bath application of enflurane (0.2-0.8 mM) and halothane (0.2-0.5 mM), which thereby induced an outward current at the resting potential, and a membrane hyperpolarization in unclamped cells. 3. The main effect of enflurane (0.5 mM) was to displace the steady-state IH activation curve to a hyperpolarizing direction by about 10 mV, as well as to reduce the maximum H-conductance to about 20%. 4. Forskolin (1-10 microM), which enhances IH by producing a depolarizing shift in the IH activation curve and increasing the maximum H-conductance, recruited IH even when the current had already been eliminated by enflurane (1 mM).

Anesthetics↗
PubMed1990

[Intraoperative ischemic change demonstrated on lead V5 related to hemodynamic episodes as well as sites and degree of coronary vascular lesion].

Electrocardiographic (ECG) changes demonstrated on lead V5 were investigated regarding the effect of hemodynamic change as well as site and degree of the LAD stenosis. Results were summarized as follows. 1. Myocardial ischemic changes on lead V5 occurred in the patients with two or more stenosis on LAD when heart rate increased. 2. Total occlusion of LAD with collaterals from stenosed RCA showed ischemic change on hypotension due to partial perfusion of cardiopulmonary bypass. 3. Ischemic changes occurred in patients with spontaneous angina and non-transmural myocardial infarction when the pericardium was opened. 4. Induction of anesthesia with fentanyl and droperidol kept blood pressure lower, but with this method no ischemic change on lead V5 occurred before CPB.

Aged↗
PubMed1989

Unique changes found on the Qi Gong (Chi Gong) Master's and patient's body during Qi Gong treatment; their relationships to certain meridians & acupuncture points and the re-creation of therapeutic Qi Gong states by children & adults.

Changes taking place in both Qi Gong Masters and their patients during Qi Gong treatment were evaluated using the Bi-Digital O-Ring Test. During the Qi Gong state, on the Qi-Gong Master's body, as well as the body of the patient being treated, acupuncture points CV5 (Shi Men) and CV6 (Qi Hai)-- located below the umbilicus-- show changes from +4 in the pre-Qi Gong state to between -3 and -4 during the Qi Gong state. Before and after the Qi Gong, there is a normal +4 response to the Bi-Digital O-Ring Test at these acupuncture points. Similar changes were also observed on acupuncture points CV17 (Shan Zhong), CV 22 (Tian Tu), Yin Tang (at an area just between the eyebrows: the pituitary gland representation area, colloquially known as the "third eye") and GV20(Bai Hui), the entire pericardium meridian & triple burner meridian, their acupuncture points, the adrenal glands, testes, ovaries and perineum, as well as along the entire spinal vertebrae, particularly on and above the 12th thoracic vertebra, medulla oblongata, pons, and the intestinal representation areas of the brain located just above and behind the upper ear. Using these findings as criteria for evaluating the effectiveness of reaching the Qi Gong state, we were able to reproduce during the experimental trials similar changes in ourselves and the patient being treated with therapeutic effects comparable to those of the Qi Gong Master. Beneficial effects of external Qi Gong treatment given by a Qi Gong practitioner 1 to 3 times for 10-20 seconds each (although most Qi Gong masters take 3-20 minutes per treatment) often resulted in improvement of circulation and lowering of high blood pressure, as well as relaxation of spastic muscles, relief of pain, and enhanced general well-being, all of which resemble acupuncture effects. In order to reproduce the same procedure with others, we selected 4 children ranging between 8 and 11 years of age who had no knowledge of Qi Gong or Oriental medicine. One of these four children, the 8 year old, was able to consistently reach the same Qi Gong state after less than a half day and another child, 11, after less than 2 days. Within a week, the other two were sometimes able to reproduce the Qi Gong state but not always. Using the Qi Gong state thus obtained, it was found that this type of Qi Gong energy is directed to specific directions from the hand and can even penetrate wooden or metal doors.(ABSTRACT TRUNCATED AT 400 WORDS)

Acupuncture Therapy↗
PubMed1989

[Clinical study of large doses of vecuronium; duration of initial and additional doses].

Neuromuscular blockade by large doses of vecuronium was investigated clinically and the duration of action of initial doses (0.2 mg.kg-1 and 0.3 mg.kg-1) and additional doses (0.01 mg.kg-1 and 0.02 mg.kg-1) were measured under enflurane-nitrous oxide anesthesia using a neuromuscular transmission monitoring system (Accelograph). In group A (initial dose = 0.2 mg.kg-1, additional dose = 0.02 mg.kg-1), the time of spontaneous recovery to 25% of control twitch height (T25) and 50% of control (T50) were 63.1 and 82.0 minutes respectively. The T50 interval of the two adjacent added doses (given at the time point of 50% recovery from the previous dose) was 31.1 minutes. Reversal time from TOF ratio = 25% to 75% after administration of edrophonium was 6.1 minutes. In group B (initial = 0.3 mg.kg-1, add. = 0.01 mg.kg-1), T25, T50, T50 interval and reversal time were 122.6, 159.4, 39.2 and 4.6 minutes respectively. In group C (initial = 0.3 mg.kg-1, add. = 0.02 mg.kg-1), above values were 119.2, 145.8, 48.4 and 6.7 minutes respectively. In this study there was no obvious side effect associated with administration of large doses of vecuronium. These methods will be very useful for long surgical procedures.

Female↗
PubMed1988

Hemodynamic relationship between renal venous pressure and blood flow regulation during positive end-expiratory pressure.

The hemodynamic relationship between renal venous pressure (RVP) and renal blood flow (RBF) during PEEP was investigated using adult mongrel dogs. When continuous mechanical ventilation (CMV) with 10 cm H2O of PEEP was applied to dogs previously on CMV with zero PEEP, RVP increased from 6.6 to 8.7 mm Hg (p less than .01), and left RBF decreased from 66 to 57 ml/min (p less than .05). RBF recovered by 49% of the difference as soon as PEEP was discontinued when the RVP elevation was maintained at the level observed during 10 cm H2O of PEEP. With 20 cm H2O of PEEP, RVP increased further to 10 mm Hg (p less than .01) and left RBF decreased to 48 ml/min (p less than .05). When the left renal vein was occluded and the RVP was maintained at the level seen during 20 cm H2O of PEEP, left RBF recovered only 50% of the difference from the flow during zero PEEP. We conclude that the reduction in RBF with PEEP application is caused by several factors; however, RVP elevation during CMV with PEEP is influential in decreasing RBF.

Animals↗
PubMed1987

Clinical significance of mean circulatory filling pressure and cardiac preload under anesthesia.

The circulatory effects of a rapid infusion of plasma substitute with intravenous administration of nitroglycerine (TNG) were investigated in low pressure systems of anesthetized patients by measuring various hemodynamic parameters. Measurements were made when the systolic blood pressure reached 70-80% of the control value after intravenous administration of TNG at 1-2 microg/kg/min and a 3.5% modified gelatin solution (Haemaccel) at a rate of 0.5 ml/kg/min. After the TNG was administered, the mean circulatory filling pressure (Pms) decreased, and the venous to arterial capacitance ratio (CV/CA) increased; however, they returned to control values after a rapid Haemaccel infusion. Changes in the pressure gradient between the X and Y valley of the right atrial pressure wave decreased to 70 +/- 14% of the control value when TNG was given and recovered to 106 +/- 22% by infusion. Pulmonary vascular resistance (PVR) decreased to 70 +/- 24% of the control value when TNG was administered and was restored to 96 +/- 40% by a rapid infusion. In the left ventricle, the mean velocity of myocardial circumferential fiber shortening (VCF) decreased in all cases when TNG was given and it recovered by a rapid infusion. In the right ventricle, VGF did not always decrease, and in a few case increased, but all cases recovered by a Haemaccel rapid infusion. We conclude that the augmentation of the right ventricular preload reserve is achieved by administration of TNG and infusion of a plasma substitute.

Journal Article↗