[Improvement of the method of gathering of hepatitis A viruses and its evaluation by water analysis].
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Antibodies, Viral↗
Biomedical subjects
T N Bystrova
Publications and source records attributed to T N Bystrova.
[The epidemiological patterns of hepatitis non-A, non-B].
The etiological structure of viral hepatitides in three cities of the Volga region was studied. The proportion of hepatitis non A, non B was established: it varied from 3.6% to 18.1% at different territories and depended on the total morbidity level, on the season, as well as on the age of patients. A suggestion was made concerning the role of the parenteral mechanism of the transfer of hepatitis non A, non B at the territory under study.
Age Factors↗
[A trial to decrease hepatitis A morbidity in Dzerzhinsk, Gorki Province].
The results of experience in the comparative evaluation of the preseasonal immunoglobulin prophylaxis in two towns of the Gorki Province are presented. The work substantiates the economic and epidemiological effectiveness of immunoglobulin prophylaxis at the territory, relatively safe with respect to hepatitis A, under the conditions of its realization in the year of the predicted rise of morbidity, the timely organization of immunoglobulin prophylaxis (from July to the first half of October) and the coverage of "organized" children, exceeding 90%.
Child↗
[Etiological structure of viral hepatitis in the area about one of the cities in Gorki Province].
The etiological structure of viral hepatitides (VH) in one of the towns of the Gorky region was studied with the use of specific methods for diagnosing hepatitis A (detection of IgM to hepatitis A virus) and hepatitis B (detection of HBsAg in the passive hemagglutination test). The study revealed that hepatitis A was the major nosological from in the structure of VH among children and adults in the area under survey, which was documented by the detection of IgM to hepatitis A virus. The form, second in importance among VH cases, was hepatitis B. The ratio of these two forms of VH was determined by the epidemiological situation in the area. The proportion of hepatitis B cases increased at the period between epidemics. Nondifferentiated hepatitis constituted 6.8% of all cases of sporadic hepatitis among adults. In 90% of cases clinical diagnosis coincided with the serological one.
Adolescent↗
[The modelling of hepatitis A in macaques].
Characteristics of experimental hepatitis A in Macaca fascicularis and M. mulatta produced with HAV, strain MP, isolated from M. mulatta in an outbreak of spontaneous hepatitis are presented. The HAV-MP strain induced the disease in all the animals used in the experiment. The infection was manifest, with all virological, serological, biochemical and morphological features typical of hepatitis A. In M. mulatta, the process was protracted, with virus persistence in feces for at least 4 months. Modeling of hepatitis A in Macaca monkeys using HAV-MP strain may be used for the study of the pathogenesis and trials of immune preparations.
Alanine Transaminase↗
[Preparation of conjugates for an immunoenzyme method of diagnosing viral hepatitis A].
Evaluation of the activity of peroxidase conjugates with immunoglobulins isolated by different methods from the sera of the subjects with a history of virus hepatitis A, and at various molar ratios of peroxidase and immunoglobulins showed the activity of immunoperoxidase conjugates to depend upon the method of isolation of immunoglobulin used for conjugation. The most active immunoperoxidase conjugates were obtained with immunoglobulins isolated by a column-free method on sephadex DEAE-50A. When peroxidase with a low specific activity is used, the quality of conjugate may be improved by increasing the amount of the enzyme added in conjugation.
Chromatography, Affinity↗