[A device for the local treatment of diseases of the distal large intestine].
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Biomedical subjects
Publications and source records attributed to T N Khristich.
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The authors suggested and tried a method for the treatment of chronic (nonulcerative) colitis using the trace element-vitamin-energy infants products for enteral nutrition Malysh, Detolact or Vitalact combined with intestinal administration of the antiinflammatory-repair-anesthetizing aerosol remedies Olasol, Cimesol, Levovinisol, Vinisol or Livian. The method is characterized by an appreciable medical and economic efficacy, it is unsophisticated and can be widely used in medical practice at all stages of the treatment.
Problems of dispensary management of patients with chronic pancreatitis are analyzed on the basis of 186 cases. The role was determined of some risk factors, chronicity and recurrence of the disease, status of the general adaptation reaction, psychoemotional background, significance of the status of the adjacent digestive organs, period of exacerbation, unstable remissions, terms of prehospital treatment, hospital treatment, presence of continuity of treatment at its stages. The authors propose a scheme of treatment, dispensary management and secondary prophylaxis in outpatient conditions directed to increase the efficacy of medical measures and ensuring thus working capacity and stabilization of the process.
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A study was made of external secretory pancreatic function in 167 patients with chronic primary gastroduodenitis (CPGD), 64 with duodenal ulcer (DU) and 10 healthy persons using a method of endogenous and exogenous (in some of the patients) stimulation with secretin and pancreozymin. The phasic nature of these disturbances was revealed. At early stages it manifested itself in an increase in the volume of juice production and bicarbonate debit, later on-in a decrease in bicarbonate excretion with a tendency to an increase in amylase and trypsin activity, in a prolonged course--in a progressive decrease in bicarbonate excretion and activity of one or two enzymes. Correlations of clinical signs with endoscopic and histological changes in the gastric mucosa, disturbances of the biliferous tracts were noted. More significant reversibility of deviations revealed during treatment in CPGD as compared to duodenal ulcer was established. The authors recommended that the disturbances revealed should be taken into account in the course of therapy and prophylaxis.
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In old and senile persons, chronic pancreatitis is known to be accompanied by an uncontrolled intensification of process of free-radical lipid oxidation and inhibition of mechanisms of antiradical defence. The use of erbisol in the instituted therapeutic complex has been found to raise the efficiency of the system of glutathione and glutathione-dependent enzymes, to effect the inhibition of process of free-radical oxidation, improvement of conditions under which the synthesis of reduced glutathione is normally seen to proceed, realization of antiperoxide, disulphide reductase- and ribonucleotide reductase functions of the system as a whole. Moreover, there gets improved the incretory and exacrinous functions of the pancreas.