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Biomedical subjects

T N Smirnova

Publications and source records attributed to T N Smirnova.

At least 19 recordsLinked to original sources
PubMed1999

[The detection of cerebral circulation changes in children by Doppler ultrasonography in ambulatory care].

To determine the role of ultrasonic and transcranial dopplerography in investigation of both arterial and venous systems of children's head in conditions of outpatient clinic were observed 100 children aged 4-14 years with autonomic dysfunction, migraine, neurosis-like and closed cerebrocranial trauma (concussion of the brain). There were estimated the qualitative indices of dopplerography (a form, distributions of the frequencies in spectrum, direction of the blood flow, acoustic characteristics) and quantitative indices (systolic, diastolic, mean rate of blood flow, indices RI and S/D) and alterations in venous circulation. In all the groups of children there were found angiodystonic manifestations in the form of the increase of vessels resistance in 87.5-97.6% of the patients; besides, the signs of venous dysgemia were observed in 28-50% of the cases.

Adolescent↗
PubMedDate not supplied

[Toxicological characterization of calcium ketopantoylaminobutyrate].

The investigation of toxicity of calcium ketopantoylaminobutyrate (Ca-KPAB) showed that this newly synthesized compound belongs to the class of low-toxicity substances. The LD 50 of Ca-KPAB for oral administration is lower than that of pantogam. No toxicity manifestations and local irritant activity was observed upon chronic administration of Ca-KPAB. The therapeutic index of Ca-KPAB is more than 17 times that of pantogam.

Administration, Oral↗
PubMedDate not supplied

[Comparative investigation of calcium ketopantoylaminobutyrate and pantogam: tranquilizer activity].

Comparative study of the sedative (calming) properties of the new drug calcium ketopantoylaminobutyrate (Ca-KPAB) and the reference drug pantogam (calcium homopantotenate) showed that the newly synthesized compound produces a more pronounced calming action in several standard neuropharmacological tests (spontaneous motor activity, barbiturate antagonist, etc.) and exhibits some additional advantages. Thus, a slight modification of the chemical structure made possible a significant reduction in the effective drug dose.

Aminobutyrates↗
PubMedDate not supplied

[Antihypoxant and antiamnesic effects of calcium ketopantoylaminobutyrate].

Experimental investigation of calcium ketopantoylaminobutyrate (Ca-KPAB), a new drug with a structure close to that of pantogam, showed that Ca-KPAB exhibits a pronounced antihypoxant effect on the normobaric and histotoxic hypoxia models. The new drug also produced a more pronounced antiamnesic action as compared to that of pantogam. A significant decrease in the effective drug dose in the case of Ca-KPAB is explained by its ability to readily bypass the blood - brain barrier.

Aminobutyrates↗
PubMedDate not supplied

[Poly(ADP-ribosylation) of proteins determines the pool of endogenous NAD and the radiosensitivity of thymus lymphocytes].

A decrease in the endogenous NAD content that occurs immediately after gamma-irradiation of thymus lymphocytes is attributed to activation of poly (ADP-ribosylation) and not to changes in the activity of NAD-glycohydrolase and/or to the release of NAD from cells. The addition of benzamide 60 min before irradiation prevents the postirradiation drop of the NAD level and produces a radioprotective effect. At the same time, benzamide inhibits nuclear superhelix DNA repair and causes an average of 40 per cent decrease in the activity of DNA ligases I and II. The authors discuss the idea that the content of intracellular NAD in thymocytes is a critical factor responsible for the vitality of these cells.

Animals↗
PubMedDate not supplied

[125I-n-iodophenamine as a prototype compound for the study of microsomal oxidation].

Dynamics of distribution and excretion with urine of 125I-p-iodophenamine were studied impairment of rat liver tissue microsomal oxidation by means of CC14 treatment. This poison inhibited distinctly metabolism and excretion of the labelled compound in rats but not in rabbits, which was due to difference in the mechanisms of the compound biotransformation. The requirements for compounds suitable for studies of microsomal oxidation by means of excretory test were not met by 125I-p-iodophenamine.

Amphetamine↗
PubMedDate not supplied

[Comparative study of the vitamin activity of pyridoxal phosphate and pyridoxine used cutaneously].

In white rats with B6-avitaminosis, the B6-vitamin activity of pyridoxal-phosphate and of pyridoxine was studied in their epicutaneous and peroral application. It is revealed that pyridoxal-phosphate in epicutaneous application displays more activity than pyridoxine and pyridoxal-phosphate applied perorally. Pyridoxine in epicutaneous application does not reveal the B6-vitamin activity.

Administration, Oral↗