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Biomedical subjects

T N Trofimova

Publications and source records attributed to T N Trofimova.

At least 19 recordsLinked to original sources
PubMed2004

[Role of cytologic and histologic examination in the diagnosis of thyroid diseases in patients exposed to radiation].

Complex cytological and ultrasound study was conducted in 300 patients with thyroid pathology exposed to 5-250 cSv. Benign goiter changes and autoimmune thyroiditis were detected in 66.2% while malignant thyroidal nodules--in 3.7%. Benign and autoimmune changes alone were in 38%. Pathomorphological features of nodular changes and autoimmune thyroiditis patterns as well as their ultrasound representations were identified.

Adult↗
PubMed2002

[Multiple sclerosis with childhood onset].

The clinical manifestations, magnetic resonance imaging (MRI) data, blood and cerebrospinal fluid (CSF) tests were analyzed in 19 patients with early-onset (before the age of 17 years) multiple sclerosis (MS) and in 100 patients with the definite diagnosis of MS with adult onset. Between group differences in sex ratio and initial neurological symptoms, with the prevalence of acute brainstem dysfunction (37%) and optic neuritis (37%) in the patients with early onset MS, were revealed. In childhood, the disease course was poorer with early disablement on the background of attendant unfavorable conditions. A sensitivity of various MRI parameters was analyzed and the essential proportion of the tumor-like acute inflammatory lesions was shown in early onset MS (29%). Immunological tests (albumin coefficient evaluation) revealed that in early onset MS hematoencephalic barrier dysfunction was registered more often, comparing to adult onset MS (100% vs 50%). The peculiarities of biases in concentrations of kappa-free and lambda-free light immunoglobulin chains in blood and CSF were detected. Higher levels of the kappa-free light chains concentrations in CSF were mostly found in the patients both with early and adult onset MS (86% and 99%, respectively) that confirmed the diagnostic value of this index. The results obtained may improve MS diagnosis in children.

Adolescent↗
PubMed2002

[Possibilities of magnetic resonance visualization in the diagnosis of multiple sclerosis].

Magnetic-resonance imaging (MRI) is considered to be the most informative non-invasive method in diagnosis, differential diagnosis and estimation of activity of multiple sclerosis (MS). MRI data of 270 patients with clinically and laboratory definite MS were analyzed to assess diagnostic MRI-criteria for MS, MRI presentations at the time of first clinical manifestation of the disease, neuroimaging patterns in children and elderly persons with MS. The MRI variants of MS are substantiated. Neuroimaging data of cervical spinal cord in 28 patients with MS are presented in parallel with corresponding clinical data. The most typical patterns are singled out. The data of brain 1H-magnetic-resonance spectroscopy (MRS) in 20 patients with MS and 8 patients with inflammatory and vascular disorders were analyzed to reveal biochemical distinction between MS and non-MS lesions as well as changes in normal appearing white matter in MS. The differential-diagnostic value of MRS is limited although decreased N-acetyl-aspartate peak is characteristic for MS lesions and in some cases in normal appearing white matter in primary-progressive MS.

Brain↗
PubMed1990

[Roentgenological diagnosis of acute lesions of the lungs with disorders of blood circulation and vascular permeability].

To specify differential and diagnostic criteria of hemodynamic and non-hemodynamic pulmonary edema, canine experimental simulation (15 trials) of different types of abnormal hemodynamic and lung capillary permeability parameters was carried out. The X-ray pictures of 71 patients with and acute diffuse lesion of the pulmonary vascular channel (including 51 with adult respiratory distress and 20 with hemodynamic pulmonary edema) was analysed. The findings substantiated the possibility of making a differential diagnosis of pulmonary edema of various genesis. Symptom complexes, typical of predominantly higher permeability of the lung capillaries and hemodynamic disturbance, were formulated.

Acute Disease↗
PubMed1989

[Radiologic features of respiratory distress syndrome].

An analysis of roentgenograms of 50 patients with a respiratory distress-syndrome has shown that roentgenosemiotics of this complication discloses alterations of permeability of pulmonary and bronchial capillaries, drainage of liquid from the interstice and alveoli, hemodynamics in the microcirculation link of the lesser circulation circle. A classification of the respiratory distress-syndrome is proposed which includes 3 stages and a period of involution of the process.

Adult↗
PubMedDate not supplied

[Ultrasonography in the diagnosis of diffuse fibrocystic mastopathy].

The breast of 160 females clinically diagnosed as having diffuse fibrocystic mastopathy and 61 females without clinical manifestations of breast diseases were echographically studied. The ultrasonographic design included measurement of the layer thickness of glandular tissue and its echodensity. In all diffuse mastopathies, including cystic one, there was over 14-mm glandular tissue thickness in all the portions of the breast or in its any quadrant, as well as glandular tissue echodensity changes which do not correspondent to the patients' age. In the control group, the thickness of a glandular layer varied with age, but it was no greater than 14 mm. Thus, the studies have demonstrated that over 14-mm glandular layer thickness and age-unspecific glandular tissue changes are the symptoms of diffuse fibrocystic mastopathy. The authors propose to include the measurement of these parameters into breast ultrasonographic methods since this allows one not only to make a more accurate diagnosis, but to clearly identify an echographic type of mastopathy.

Adult↗
PubMedDate not supplied

[Ultrasound and morphological diagnosis of thyroid diseases in radiation-exposed persons].

The purpose of the present investigation was to enhance the efficiency of diagnosis of thyroid diseases in irradiated persons. Three hundred persons exposed to radiation in doses of 5 to 250 SeV and the postexposure period was 9 to 48 years. A control group comprised 100 military men unexposed to ionizing radiation. Thyroid ultrasound study and morphological diagnosis revealed diffuse nodular goiter transformation in 66% of the irradiated persons and malignant thyroid neoplasms in 3.7% whereas 38% of the control patients were found to have only benign diffuse nodular thyroid alterations and autoimmune thyroiditis (AIT). The investigation identified the echosemiotic features of nodular masses and AIT in the study group patients and established their association with the pathomorphological changes of the thyroid. The authors note the high efficiency of complex clinicoradiation and morphological studies in detecting thyroid pathology and the priority in establishing an accurate diagnosis at the preoperative stage and in determining management tactics.

Chernobyl Nuclear Accident↗
PubMedDate not supplied

[Optical image processing in the analysis of the structural elements of the x-ray picture of the adult respiratory distress syndrome].

The paper is devoted to the potentialities of aposterior image processing in adult patients with the respiratory distress-syndrome (RDS). Thirty one cases of optical processing of radiograms were analyzed. Pulmonary changes were absent in 10 persons of the control group. The authors described spatial and frequency characteristics of the structural elements of an x-ray picture of RDS (change of interstitial tissue, the state of pulmonary markings, micro-atelectases, edematous and small hemorrhagic parts). The localization of disease is mostly peripheral. The authors paid attention to probable criteria of differential diagnosis between RDS and other conditions, manifesting themselves in clinically acute parenchymatous respiratory insufficiency (lung edema, acute pneumonia, thromboembolism of the pulmonary artery).

Densitometry↗