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Biomedical subjects

T N Zaboĭkina

Publications and source records attributed to T N Zaboĭkina.

4 recordsLinked to original sources
PubMed1982

[Effect of protein on the induction and renewal of a cytochrome P-450 complex in the rat liver].

It was disclosed that the effect on the content of cytochrome P450 and renewal of the protein portion of the cytochrome P450 complex in rat liver microsomes is determined by the protein amount in the diet. Protein deficiency in the diet leads to the reduced rate of protein fraction renewal in the cytochrome P450 complex. The degree of cytochrome P450 induction with phenobarbital was found to be dependent on the diet. In the animals fed low-protein diet (4.5%), the degree of cytochrome P450 induction was decreased which was likely to be a consequence of the increased semi-renewal period.

Animals↗
PubMedDate not supplied

[Isolation and characteristics of 2 transcribing families of pigeon-genome repetitive sequences].

From pigeon DNA two families of repeats have been isolated: one (frequency of repetitions 30--40 times per haploid genome) actively transcribing and the second (frequency of repetitions 2000--2800 times) weakly transcribing in erythroid cells. The reassociation kinetics, GC-content and size of isolated repeats were investigated. Actively transcribing repeats (average length of 350 nucleotides) contain about 55% GC-nucleotides and alternate in the genome with AT-rich sequences of the unique type. Comparison of isolated families of repeats revealed differences in the structure and posttranscriptional fate of RNA transcribed from them.

Animals↗
PubMedDate not supplied

[Effect of diets with different carbohydrate/fat ratios on the cytochrome P-450 content and monooxygenase activity of rat liver].

Wistar male rats kept on high-protein (36% protein) diets for 30 days showed an increase in the content of cytochrome P-450 and b5 in liver microsomes, which was accompanied by an increase in the rate of amidopyrine and aniline oxidation. The degree of induction of the monooxygenase system of the liver endoplasmic reticulum with phenobarbital (100 mg/kg bw daily for 4 days) in rats which received high-protein diets was lower than in control and depended on the carbohydrate/fat ratio in the diet.

Animal Feed↗