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T NOGUCHI

Publications and source records attributed to T NOGUCHI.

At least 19 recordsLinked to original sources
PubMed1957

Further studies on BCG vaccine prepared by tween 80 method with particular reference to effect of freeze-drying.

The immunizing potency of liquid BCG vaccine prepared by the Tween 80 method was compared with that of control vaccine prepared by the usual grinding method. The former vaccine revealed higher immunizing properties than the latter although its inoculation dose was only one-fifth as great.With sodium glutamate as adjuvant, freeze-drying was carried out on both vaccines. The viability of the resulting dried product was higher with the Tween 80 vaccine than with the control vaccine up to 12 months' preservation at 5 degrees C, and the allergenic potency of the dried Tween 80 vaccine stored at 5 degrees C was higher than that of the control vaccine. When the dried vaccine was preserved at 37 degrees C for a long period, the degree of decrease in viability was more marked in the Tween 80 vaccine than in the control vaccine.

BCG Vaccine↗
PubMed1956

Effect of preservation on the viability and allergenic potency of dried BCG vaccine.

Although many studies have been made on the lyophilization of BCG vaccine, few reports on its stability have appeared. The amount of living bacilli present in the vaccine and its allergenic potency can be considered to be an indication of the stability of the vaccine. The authors have already reported on the change in viability of vaccines preserved for 17 months; in this paper two experiments on lots of vaccines preserved for three years are discussed. The authors determined changes in viability after storage and examined tuberculin reactions one to eighteen months after vaccination. It was observed that the vaccines which had a relatively high potency at the time of lyophilization maintained their ability to induce allergy for at least two years.

Allergens↗