Biomedical subjects

T Nagayo

Publications and source records attributed to T Nagayo.

At least 37 records · Page 2Linked to original sources

PubMed1980

Primary tumors of the esophagus other than squamous cell carcinoma--histologic classification and statistics in the surgical and autopsied materials in Japan.

Clinicopathological features of 405 patients with esophageal tumors other than squamous cell carcinoma, which were resected surgically at 68 institutions in Japan, were analyzed and compared with those of 4,995 cases of esophageal malignant neoplasms autopsied during 19 years (1958-1976) in Japan. Of 405 surgical cases, 149 were benign tumors, most of which (89%) were leiomyomas. The incidence of malignant tumors other than squamous cell carcinoma was 2.1% in the surgical, and 7.2% in the autopsied cases of esophageal cancer. Malignancies were classified into 15 histologic types. Most of them did not differ in sex and age incidence or location of the primary site from squamous cell carcinoma, except for adenocarcinomas, in which there was a greater incidence of occurrence in the lower portion of the esophagus. Carcinosarcomas and pseudosarcomas showed peculiar clinical and pathological characteristics. Overall prognosis was poor except in cases of pseudosarcoma and leiomyosarcoma.

Adenocarcinoma↗

PubMed1978

Recent changes in the morphology of gastric cancer in Japan.

The macroscopical and histological features of 4,428 cases of gastric cancer resected stomachs was noted.d surgically between 1953 and 1974 were studied. Of these cases, 81.9% were in an advanced stage and 18.1% in an early stage. The following changes were observed. (1) In the group of advanced cancers, a gradual decrease in the frequency of Borrmann II type was noted. Most of these tumors were well-differentiated adenocarcinomas. (2) In the group of early cancers, a gradual increase in the proportion of "cancerous erosion" was detected. The majority of these tumors were poorly differentiated adenocarcinomas or infiltrating signet-ring cell cancers. (3) At intervals of 10 years, 5-10% decrease in the frequency of intestinal metaplasia in resected stomachs was noted.

Adult↗

PubMed1977

Electron microscopic study of signet-ring cells in diffuse carcinoma of the human stomach.

The signet-ring cells seen in gastric carcinoma of the diffuse type were studied by light and electron microscopy. A classification of these cells into Types A, B and C was developed, based on intracellular mucous granules, nuclei and organelles, and be reactions to PAS and Alcian-blue staining. The gradual transition of type A cells to Type B and the subsequent change of Type B to Type C suggest successive stages in maturation. These cells, especially those of Type B, resemble the mucous neck cells of the corpus and the glands of the pylorus.

Adenocarcinoma, Mucinous↗

PubMed1977

Electron microscopy of a ciliated cell in the human stomach.

A ciliated cell was observed electron microscopically in a pyloric gland with intestinal metaplasia. This specimen was obtained from the gastric antrum of a 61-year-old man suffering from gastric cancer. The cell had flask-like contour and possessed numerous cilia protruding from the free surface of a deeply indented cytoplasm into the glandular lumen. Most cilia were similar in structure to normal kinocilia and had nine peripheral doublets and two central microtubules (9 + 2 configuration). Some cilia, however, showed varying configurations, such as 9 + 0,9 + 3, or 9 + 4. The occurrence of ciliated cell in human stomach may be related to the disturbance of cellular differentiation of the gastric primordial cells during metaplastic change.

Cilia↗

PubMed1977

Cytoplasmic leucine naphthylamidase activity expressed in signet-ring cell carcinoma of the stomach.

Histochemical studies were performed on signet-ring cells in surgically resected gastric carcinomas from 64 patients. On the basis of periodic acid-Schiff reactivity of the intracellular mucin, the signet-ring cells were classified as type A (immature), type B (intermediate), or type C (mature). Different staining reactions to Alcian blue at pH 2.5 enabled type C cells to be subclassified as C-1 or C-2. In 63 cases (98.4%), intense leucine naphthylamidase (LNAase) activity was found histochemically in the cytoplasm of nearly all cancer cells except type C-2. Localization of LNAase activity in the cytoplasm was confirmed by conventional biochemical assay. From the present results, histochemical characteristics of signet-ring cell carcinoma are discussed.

Adenocarcinoma, Mucinous↗

PubMed1977

Kinetics of preneoplastic epithelia of the the intestinal mucosa induced in Buffalo rats by oral administration of N,N'-2,7-fluorenylenebisacetamide.

A diet containing 0.025% of N,N'-2,7-fluorenylenebisacetamide (2,7-FAA) was administered orally to 18 Buffalo rats for 3 months and to 21 rats for 5 months which corresponded to non-neoplastic stage and preneoplastic stage of carcinogenesis of the intestinal mucosa, respectively. The mitotic index, labeling index, and generation time of the epithelia of the intestinal mucosa of these stages were examined by autoradiography. 1) The mitotic index and labeling index decreased in the rats fed 2,7-FAA for 3 months than those of the non-treated controls. 2) Decrease of both indices was also observed in the rats fed 2,7-FAA for 5 months, except for the proximal part of the colon. 3) Around 1-hr prolongation of the generation time was observed in the epithelia of rats fed 2,7-FAA for 3 months compared with the non-treated control rats, and this was mainly due to the prolongation of the duration of the G1 phase. 4) Two- or three-hour prolongation of the generation time was observed in the epithelia of rats fed 2,7-FAA for 5 months compared with the non-treated control rats, and this was mainly due to the prolongation of the duration of the S phase.

2-Acetylaminofluorene↗

PubMed1976

Histochemical patterns in early lesions and infiltrating adenocarcinomas induced in mouse duodenum by n-ethyl-n'-nitro-n-nitrosoguanidine.

Intravillous, microcrater, and macroscopic invasive lesions induced in the mouse duodenum by N-ethyl-N'-nitro-N-nitrosoguanidine were examined histochemically. The cells of these neoplastic lesions and the proliferative zones of the normal crypts showed similar staining reactions in leucine aminopeptidase, alkaline and acid phosphatases, adenosine 5'-triphosphatase, and glucose-6-phosphate dehydrogenase. However, a slight decrease in succinic dehydrogenase activity and a slight increase in lactic dehydrogenase activity were observed in the intravillous and microcrater lesions compared to the activity in the proliferative zones of the crypts. The neoplastic cells of these lesions showed no mucus secretion. We discussed the origin of the neoplastic lesions using these and other findings.

Acid Phosphatase↗

PubMed1975

Microscopical cancer of the stomach--a study on histogenesis of gastric carcinoma.

In order to elucidate the histogenesis of gastric cancer preceded by "chronic gastritis", 67 foci (58 cases) of minute cancer less than 5 mn in largest diameter were examined histologically. The results obtained were as follows: (1) Except in two cases, all minute cancerous foci were found unexpectedly in the mucosa of the antrum or of the angulus having peptic ulcer or gastric cancer. They were more frequent in the lesser curvature than in other parts of the stomach. (2) Histologically, 18 foci were found in an area close to the main lesion, while 40 were far from the lesion. Seven foci were detected in the mucosa adjacent to ulcer scars. (3) In retrospective macroscopical examinations, 41 foci showed minimal erosion or tiny depressions on the affected mucosa, while in the other 26 no recognizable changes were observable. (4) Histologically, the gastric mucosa outside the cancer lesions was more or less atrophic with or without intestinal metaplasia. (5) Regardless of histological types, all the minute cancers were found in the transitional zone between foveolar epithelium and pyloric glands corresponding to "generative cell layer" in autoradiographic studies. (6) Poorly differentiated adenocarcinomas containing signet-ring cells occurred most often in combination with no or slight intestinal metaplasia of the mucosa, while well-differentiated adenocarcinomas were always found in ventricles with severe intestinal metaplasia.

Adenocarcinoma↗

PubMed1975

Ultrastructure of spontaneous and urethan-induced thymomas in buffalo rats.

Normal thymuses from Buffalo and Long-Evans rats of various ages, and spontaneous and urethan-induced thymomas in Buffalo rats, were examined by electron microscopy. Histological variabilities among thymomas of the lymphoid, mixed, and epithelial cell types were a reflection of the number of lymphoid cells within the network composed of neoplastic epithelial reticular cells. In the cytoplasm of these cells, development of tonofilaments and membrane-bound bodies and inverse development of the rough-surfaced endoplasmic reticulum were recognized in the sequential process from the lymphoid cell type to the epithelial cell type. An important role of the development of the rough-surfaced endoplasmic reticulum for thymic function was suggested. Phagocytic activity of the neoplastic epithelial reticular cells was revealed, and some of the membrane-bound bodies in these cells, especially those with moniliform structures, were regarded as remnants of damaged lymphocytes. Evidence for neoplastic epithelial reticular cell-lymphoid cell transformation could not be established from study of the thymoma tissue. No virus-like structures were observed in these thymomas.

Animals↗

PubMed1974