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Biomedical subjects

T Nakane

Publications and source records attributed to T Nakane.

104 records · Page 6Linked to original sources
PubMed1979

[The correlationship between basal prolactin levels and the suppressive effect of CB-154 or L-DOPA on GH release in acromegalic patients (author's transl)].

It has been reported that the plasma growth hormone (GH) and prolactin (PRL) levels in acromegalic patients were suppressed after intensive administration of dopaminergic drugs, but we found that the plasma GH levels in some acromegalic patients were not suppressed. Plasma GH and PRL levels after a single oral administration of CB-154 (2.5mg) and L-DOPA (1g) were measured in 18 active acromegalic patients with and without galactorrhea. 1. The mean plasma GH levels after the administration were clearly suppressed in 8 patients with galactorrhea, while they were not suppressed in 10 patients without galactorrhea. These drugs were more effective in suppressing plasma GH levels in acromegalic patients with galactorrhea and hyperprolactinemia. 2. We calculated the responsiveness of the plasma GH level as follows: GH responsiveness (%) = (mean plasma GH level after the administration of CB-154 or L-DOPA)/ (basal GH level) x 100. The basal plasma PRL levels were inversely correlated with GH responsiveness (CB-154: r=-0.690, p less than 0.01. L-DOPA: r=-0.541, p less than 0.05). It was found that the effect of dopaminergic drugs on plasma GH levels was closely correlated with basal PRL levels in acromegalic patients. This implies that the chronic administration of CB-154 may be effective in acromegalic patients with galactorrhea and hyperprolactinemia.

Acromegaly↗
PubMedDate not supplied

Remarkable antiagglomeration effect of a yeast biosurfactant, diacylmannosylerythritol, on ice-water slurry for cold thermal storage.

Antiagglomeration effects of different surfactants on ice slurry formation were examined to improve the efficiency of an ice-water slurry system to be used for cold thermal storage. Among the chemical surfactants tested, a nonionic surfactant, poly(oxyethylene) sorbitan dioleate, was found to show a greater antiagglomeration effect on the slurry than anionic, cationic, or amphoteric surfactants. More interestingly, diacylmannosylerythritol, a glycolipid biosurfactant produced by a yeast strain of Candida antarctica, exhibited a remarkable effect on the slurry, attaining a high ice packing factor (35%) for 8 h at a biosurfactant concentration of 10 mg/L. These nonionic glycolipid surfactants are likely to effectively adsorb on the ice surface in a highly regulated manner to suppress the agglomeration or growth of the ice particles. This is the first report on the utilization of biosurfactant for thermal energy storage, which may significantly expand the commercial applications of the highly environmentally friendly slurry system.

Candida↗
PubMedDate not supplied

Comparative study of direct coronary vascular responses to diltiazem, adrenergic beta-blockers and other vasodilators in isolated, perfused dog and monkey coronary arteries.

The cannula-inserting method was used to examine the vascular responses of the isolated, perfused dog and monkey coronary arteries to a calcium antagonist (diltiazem), adrenergic beta-blockers (propranolol and pindolol), an antianginal drug (nicorandil) and vasodilators (hydralazine and papaverine). Propranolol and pindolol constricted the dog and monkey coronary arteries dose-dependently. Without any precontraction, hydralazine produced a biphasic response--a vasodilatation followed by a vasoconstriction--in the dog coronary artery, although it produced only a vasodilatation in the monkey coronary artery. Nicorandil and diltiazem dilated the uncontracted dog and monkey coronary arteries dose-dependently. The rank order of drug potency for inducing vasodilatation was diltiazem greater than nicorandil greater than hydralazine in both coronary arteries. These results indicate that the cannula-inserting method is useful to investigate the responses of the large epicardial dog and monkey coronary arteries to vasodilating drugs.

Adrenergic beta-Antagonists↗