PubMed Health⌕ Search

Biomedical subjects

T Nakatsui

Publications and source records attributed to T Nakatsui.

13 recordsLinked to original sources
PubMed1998

Onycholysis and thyroid disease: report of three cases.

BACKGROUND: Onycholysis is a common disorder with many causes. It is known to be associated with thyroid disease (especially hyperthyroidism), but physicians probably do not routinely screen for underlying thyroid disease. OBJECTIVE: To study the association of onycholysis and thyroid disease. METHODS: We report three patients with onycholysis who were investigated for thyroid disease. RESULTS: In two patients, onycholysis was the presenting sign of previously undiagnosed hypothyroidism, whereas the third developed onycholysis while undergoing therapy for hypothyroidism. CONCLUSIONS: These three cases appear to suggest that patients with unexplained onycholysis should be screened for asymptomatic thyroid disease.

Adult↗
PubMed1991

Properties of amphiphilic and hydrophilic forms of alkaline phosphatase from human liver.

Amphiphilic and hydrophilic forms of alkaline phosphatase differed in electrophoretic mobility, sensitivity to heat, activation by phospholipids and albumin, and affinity of monoclonal antibodies, but were similar in substrate Km and inhibitor Ki values, sensitivity to sodium dodecyl sulfate, and electrophoretic behavior on desialylation. Chemical cross-linking experiments failed to conclusively demonstrate an aggregated state of amphiphilic alkaline phosphatase in Triton X-100. Further, attempts to identify a polymeric hybrid between amphiphilic forms of human liver and placental alkaline phosphatase were unsuccessful. We conclude that the covalent attachment of the hydrophobic phosphatidyl-inositol membrane anchor causes the amphiphilic form to behave anomalously on electrophoresis and to affect certain of the enzyme's catalytic and physical properties.

Alkaline Phosphatase↗